Caleb Finch Ph.D.
ARCO/ Keischnick Professor of Gerontology and Biological Science and University Professor, Director, Gerontology Research Institute. Cell biology, mechanisms controlling postnatal development and aging in man and other mammals, Alzheimer's disease. *Chair, National research Council Committe on Biodemography of Aging: Bringing Bioindicators to household surveys. *Chair, Symposium on Slow Aging (SOSA), Sept 22-23, USC

Research and Grants

5 P01 AG026572-02
08/15/2006 - 05/31/2011
Progesterone in Brain Aging and Alzheimer’s Disease—Core A: Animal.
Core A provides all animals requested by the 5 projects within the progesterone program project.
Project 4: Progesterone, Glial Aging and Alzheimer’s Disease.
The progesterone project aims are to conduct experiments on rodent models in vivo and in vitro to analyze mechanisms by which progesterone interact with neurons and glia to modify synaptic plasticity during aging and Alzheimer’s Disease. No overlap.
Role: Project Director, Core A and Proj. 4

NIA 3-T32-AG00037
Principal Investigator: Eileen M. Crimmins
9/1/03 - 4/30/13
Multidisciplinary Research Training in Gerontology
Pre and postdoctoral research training in gerontology.

AG-SS-1355-04
11/01/2004 - 10/31/2009
ApoE Isoforms in the evolution of human diet and longevity from chimpanzee-like ancestors.This project constructs transgenic ApoE replacement mice with the mutations in ApoE predicted to have evolved that influence the onset of Alzheimer disease. No overlap.
Role: Principal Investigator

1 R21 AG031988-01
04/01/2008 - 03/31/2010
Preparation of Samples for Investigation of Biological Aging Among the Tsimane.
The project analyzes DNA of the Tsimane, an amazonian tribe which lives in a highly infected environment with scarce nutrition resources. The data produced through this project will allow us to assess how conditions in the modern world, with little exposure to infection and extensive resources, may result in adverse conditions for an aging population such as obesity and overnutrition. Results of this project will help understand the role of worldwide declines in infection throughout life in causing changes in the rate of aging in later life. No overlap.
Role: Co-Principal Investigator

Zumberge Interdisciplinary Award
01/01-09 - 12/30/09
Air Pollution Accelerates Brain Aging: Mechanisms and Interventions.
This project exposes mice to defined ultrafine particulate from fossil fuels that are known to accelerate arterial disease and that are predicted to accelerate neurdegeneration in Alzheimer transgenic mice.
Role: Principal Investigator

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