Christian Pike, Ph.D.
The Albert L. and Madelyne G. Hanson Family Trust Associate Professor in Gerontology
Division of Biogerontology
Neuronal apoptosis, Alzheimer's disease, hormonal regulation of cell viability

Publications

Pike CJ, Walencewicz AJ, Glabe CG and Cotman CW (1991) Aggregation-related toxicity of synthetic b-amyloid protein in hippocampal cultures Eur J Pharmacol 207: 367-368.

Pike CJ, Walencewicz AJ, Glabe CG and Cotman CW (1991) In vitro aging of b-amyloid protein causes peptide aggregation and neurotoxicity Brain Res 563: 311-314.

Pike CJ, Cummings BJ and Cotman CW (1992) b-Amyloid induces neuritic dystrophy in vitro: similarities with Alzheimer pathology Neuroreport 3: 769-772.

Cotman CW, Pike CJ and Copani A (1992) b-Amyloid neurotoxicity: a discussion of in vitro findings Neurobiol Aging 13: 587-590.

Pike CJ, Burdick D, Walencewicz AJ, Glabe CG and Cotman CW (1993) Neurodegeneration induced by b-amyloid peptides in vitro: the role of peptide assembly state J Neurosci 13: 1676-1687.

Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ and Cotman CW (1993) Apoptosis is induced by b-amyloid in cultured CNS neurons Proc Natl Acad Sci USA 90: 7951-7955.

Pike CJ and Cotman CW (1993) Cultured GABA-immunoreactive neurons are resistant to toxicity induced by b-amyloid Neurosci 56: 269-274.

Korotzer A, Pike CJ, and Cotman CW (1993) b-Amyloid peptides induce degeneration of cultured rat microglia Brain Res 624: 121-125.

Weiss JH, Pike CJ and Cotman CW (1994) Ca2+ channel blockers attenuate b amyloid peptide toxicity to cortical neurons in culture J Neurochem 62: 372-375.

Pike CJ, Cummings BJ, Monzavi R and Cotman CW (1994) b-Amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer's disease Neurosci 63: 517-531.

Cotman CW and Pike CJ (1994) b-Amyloid and its contributions to neurodegeneration in Alzheimer's disease. In: Alzheimer's disease (eds., Terry RD, Katzman R, and Bick K) pp 305-315 Raven Press, Ltd., New York.

Watt JA, Pike CJ, Walencewicz AJ and Cotman CW (1994) Ultrastructural analysis of b-amyloid-induced cell death in cultured hippocampal neurons Brain Res 661: 147-156.

Pike CJ, Walencewicz-Wasserman AJ, Kosmoski J, Cribbs DH, Glabe CG and Cotman CW (1995) Structureactivity analyses of b-amyloid peptides: contributions of the b25-35 region to aggregation and neurotoxicity J Neurochem 64: 253-265.

Pike CJ and Cotman CW (1995) Calretinin-immunoreactive neurons are resistant to b-amyloid toxicity in vitro. Brain Res 671: 293-298.

Pike CJ, Cummings BJ and Cotman CW (1995) Contributions of b-amyloid to reactive astrocytosis in Alzheimer's disease. In: Research Advances in Alzheimer's Disease and Related Disorders (eds., Iqbal K, Mortimer J, Winblad B and Wisniewski H) pp 619-627. John Wiley and Sons, Ltd, Sussex, England.

Pike CJ, Cummings BJ and Cotman CW (1995) Early association of reactive astrocytes with senile plaques in Alzheimer's disease Exp Neurol 132: 172-179.

Vaughan PJ, Pike CJ, Cotman CW and Cunningham DD (1995) Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults J Neurosci. 15: 5389-5401.

Anderson AJ, Pike CJ and Cotman CW (1995) Differential induction of immediate early gene proteins in cultured neurons by b-amyloid (Ab): Association of c-Jun with Ab-induced apoptosis J Neurochem. 65: 1487-1498.

Pike CJ, Overman MJ and Cotman CW (1995) Amino-terminal deletions enhance aggregation of b-amyloid peptides in vitro J Biol Chem. 270: 23895-23898.

Pike CJ, Vaughan PJ, Cunningham DD and Cotman CW (1996) Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by b-amyloid in vitro J Neurochem 66: 1374-1382.

Pike CJ, Ramezan-Arab N, Miller S and Cotman CW (1996) b-Amyloid increases enzyme activity and protein levels of glutamine synthetase in cultured astrocytes Exp Neurol 139: 167-171.

Cummings BJ, Pike CJ, Shankle R and Cotman CW (1996) b-Amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease Neurobiol Aging 17: 921-933.

Pike CJ, Balázs R and Cotman CW (1996) Attenuation of b-amyloid neurotoxicity in vitro by potassiuminduced depolarization J Neurochem 67: 1774-1777.

Deng G, Pike CJ and Cotman CW (1996) Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells FEBS Lett 397: 5054.

Cribbs DH, Pike CJ, Weinstein SL, Velasquez P and Cotman CW (1997) All-D-enantiomers of b-amyloid exhibit similar biological properties to all-L-enantiomers J Biol Chem 272: 7431-7436.

Donovan, FM, Pike CJ, Cotman CW and Cunningham DD (1997) Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and rhoA activities J Neurosci 17: 5316-5326.

Pike CJ, Ramezan-Arab N and Cotman CW (1997) b-Amyloid neurotoxicity in vitro: Evidence of oxidative stress but not protection by antioxidants J Neurochem 69: 1601-1611.

Pike CJ (1999) Estrogen modulates neuronal Bcl-xL expression and b-amyloid-induced apoptosis: relevance to Alzheimer's disease J Neurochem 72: 1552-1563.

Stoltzner SE, Berchtold NC, Cotman CW and Pike CJ (2001) Estrogen regulates bcl-x expression in rat hippocampus. Neuroreport 12: 2797-2800..

Pike CJ (2001) Testosterone attenuates b-amyloid toxicity in cultured hippocampal neurons Brain Res. 919: 160-165.

Berchtold NC, Kesslak J.P., Pike CJ and Cotman CW (2001) Estrogen and exercise interact to regulate brainderived neurotrophic factor (BDNF) gene expression in the hippocampus Eur J Neurosci 14: 1992-2002.

Soreghan B, Pike CJ, Kayed R, Tian W Milton S, Cotman C and Glabe CG (in press) The influence of the hydrophobic carboxyl terminus of the Alzheimer Ab peptide on its conformation, oligomerization and fibril assembly properties NeuroMol. Med

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