Amy S. Lee

 Ph.D.

Professor

Keck School of Medicine
Department of Biochemistry and Molecular Biology

A major research focus of her laboratory is to investigate the regulation and function of two stress-inducible proteins GRP78/BiP and GFP94. As Ca2+ binding molecular chaperones localized in the endoplasmic reticulum (ER), they play important roles in protein folding, secretion, and can confer protection against disruption of Ca2+ homeostasis. In tumor cells, induction of the GRPs correlates with resistance to cell mediated cytotoxicity. To dissect biochemically the regulatory pathways leading to grp induction in mammalian cells, she focuses on elucidating the transcriptional and post-transcriptional machinery that act on the stress response elements of the grp78 and grp94 promoter.

 

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