David K. Ann

Ph.D.

Professor
Chair

School of Pharmacy
Department of Molecular Pharmacology and Toxicology
Norris Comprehensive Cancer Center
Center for Craniofacial Molecular Biology

Dr. Ann has broad interests in elucidating the genetic mechanisms that program salivary cell differentiation and proliferation. He has demonstrated that chronic Ipr-administration induces the expression of chromosomal architectural proteins, HMGI-C, at the transcriptional level. The induction of HMGI-C expression also coincides with Raf-1 mediated transformation of salivary Pa-4 cells. However, the exact mechanism underlying this Raf-1 mediated HMGI-C induction is poorly defined. A better knowledge of molecular basis of gene regulation is the key to successful tissue regeneration, which leads to an improved salivary function through agents that act on crucial elements of signaling pathways involved in morphological and functional maturation.

 

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