Myron F. Goodman

 Ph.D.

Professor

College of Letters, Arts and Sciences
Department of Molecular Biology

His primary research goal is to understand the molecular basis of mutagenesis. He is studying biochemical and physical-chemical mechanisms governing DNA replication fidelity. DNA make mistakes at rates as often as one in a thousand, to a little as, one in a million, depending on the type of error, surrounding DNA sequence, and on the properties of enzyme. He has developed a simple polyacrylamide gel electrophoresis assay to measure DNA synthesis fidelity at any DNA template site, and we are analyzing how fidelity depends on DNA polymerase, DNA sequences, and on protein components of the replication complex. Dr. Goodman and arnheim collaborate on these research themes.

 

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