Francis S. Markland

 Ph.D.

Professor

Keck School of Medicine
Department of Biochemistry and Molecular Biology

His research is targeted to investigate the effect of a unique approach to inhibiting osteoclast resorptive function, and to examine the mechanism of action of the inhibiting agent. Complementary interests and expertise have led to a collaboration with Dr. Minkin who has been studying cellular and molecular biology of the osteoclast. Present investigations provide support for the role of the vitronectin receptor as one of the integrins involved in bone attachment and resorption. Further, there is evidence for integrin-mediated signaling in osteoclasts that have been cultured on ECM proteins containing Arg-Gly-Asp (RGD) sequences.

 

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