Michael R. Stallcup

 Ph.D.

Professor

Keck School of Medicine
Department of Pathology and Biochemistry and Molecular Biology

His project will investigate how steroid receptors interact with the transcription machinery to activate transcription of specific genes. An 810 amino acid fragment of a recently identified protein called GRIP1 interacts with the hormone binding domain of steroid receptors by interacting with the AF2 yeast, GRIP1 serves as a transcriptional co-activator for steroid recptors by interacting with the AF2 transcriptional activation domain of steroid receptors. Characterization of GRIP1 will be continued by first completing the cloning and sequencing of the coding region. The possibility that GRIP1 may interact with other nuclear receptors will be investigated.

 

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