Tina F. Jaskoll

Ph.D.

Professor

School of Dentistry

Dr. Jaskoll is using mouse genetics to establish if a relationship between the mouse H-2 complex and glucocorticoid-induced modulation of key signal transduction pathways exist during palate development. She is also investigating if H-2 haplotype-specific variation in IGF-IIR expression is related to different rates of palatogenesis and susceptibility to glucocorticoid-induced cleft palate. Drs. Jaskoll, Denny and Snead have collaborated on studies of salivary gland development. In these studies, we sought to determine if glucocorticoid-induced modulation of growth factor expression and transcription factors, such as Msx genes, are part of the mechanism(s) regulating embryonic salivary branching morphogenesis and mucin expression.

 

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