David Warburton

M.D.

Professor

Pediatrics/Childrens Hospital
Keck School of Medicine
Center for Craniofacial Molecular Biology

Dr. Warburton’s research has shown that autocrine/paracrine signaling, specifically activation of EGF receptor (EGFR) by EGF, instructs embryonic mouse lung branching morphogenesis in chemically defined culture. EGF and TGF beta signaling pathways interact to instruct pulmonary morphogenesis. This work will define molecular mechanisms of growth factor receptor mediated interactive signaling and transcriptional activation of lung developmental genes. Clinical relevance: To provide a rationale for novel approaches to peptide growth factor based pulmonary therapeutic strategies to ameliorate lung injury and augment lung repair, particularly in very immature human infants in whom lung development is incomplete at birth. Dr. Warburton collaborates with Drs. Lee and Wuenschell, and Drs. Shuler and Snead.

 

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