Yi-Hsin Liu

Ph.D.

Assistant Professor

School of Dentistry
Center for Craniofacial Molecular Biology

Dr. Liu is pursuing studies of the role of Msx1, Msx2 and twist to alter commitment to the osteoblast lineage. This work is part of the collaborative work ongoing between Drs. Liu, Maxson, and Snead on the development biology of the mammalian suture. This research team recently showed that over-expression of a mutant form of Msx2 in transgenic mice alter the rate of cell division as well as altering the expression of early markers for osteoblasts. They are pursuing the altered binding of the Msx transcription factor to regulatory elements in downstream genes, such as osteopontin, bone sialoprotein and biglycan.

 

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