CCMB Faculty

CSA 105, HSC 9062
(323)442-3174 Voice
(323)442-2981 Fax
shuler@usc.edu

Charles F. Shuler

D.M.D., Ph.D.

Associate Professor
CCMB Director (1995-2007)

Education Experience Projects Publications

Education

INSTITUTION AND LOCATION	DEGREE	YEAR(s)	FIELD OF STUDY
University of Chicago, Chicago, IL	Ph.D.	1984	Pathology
University of Minnesota, Minneapolis, MN	Resident	1980-81	Oral Pathology
Harvard School of Dental Medicine, Boston, MA	D.M.D.	1979	Dentistry
University of Wisconsin, Madison, WI	B.S.	1975	Biochemistry

Research & Professional Experience

1995-2007	George & Mary Lou Boone Chair Professor of Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA
1995-2007	Director, Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA
1993-2007	Director, Craniofacial Biology Graduate Program, School of Dentistry, University of Southern California, Los Angeles, CA
1992-2007	Associate Professor, School of Dentistry, University of Southern California, Los Angeles, CA
1989-1992	Assistant Professor, School of Dentistry, University of Southern California, Los Angeles, CA
1986-1989	Assistant Professor, Pathology, College of Medicine, Ohio State University, Columbus, OH
1984-1989	Assistant Professor, College of Dentistry, Ohio State University, Columbus, OH
1981-1984	Graduate Student in Pathology, University of Chicago, Chicago, IL
1979-1980	George C. Marshall Research Fellow, Royal Dental College, Copenhagen, Denmark
1975-1979	Research Assistant, Clinical Genetics, Children's Hospital, Boston, MA

Research Projects During the Last 3 Years

"Control of Cell Differentiation during Palatal Fusion"

Principal Investigator: Charles F. Shuler, D.M.D., Ph.D.
Agency: National Institute of Health
Type: R01 DE16296, Period: June 1, 2006 to May 31, 2011
The major goal of this project is to study the molecular mechanisms of TGF-beta3 signaling in the regulation of palatal fusion.

"Craniofacial Developmental Molecular Biology"

Principal Investigator: Charles F. Shuler, D.M.D., Ph.D.
Agency: National Institute of Health
Type: P01, Period: August 1, 1999 to July 31, 2006
The major goal of this project is the continuous long term series of collaborations that will provide an excellent scientific environment to advance the understanding of the molecular mechanisms underlying craniofacial development.

"A Center for the Study of Health Care"

Principal Investigator: Charles F. Shuler, D.M.D., Ph.D.
Agency: State of CA/Dept. Corp
Type: Western Dental/CS, Year 1-5 Period: July 1, 1998 to June 30, 2003
The major goal of this project is to focus on activities related to the development of predoctoral dental student curriculum, continuing education for practicing dentists and evaluation of the impact of curricular topics on dental practice patterns.

"SMAD-Mediated Signaling During Prostate Growth and Development"

Principal Investigator: Charles F. Shuler, D.M.D., Ph.D.
Agency: U.S. Army Medical Research Acquisition Activity
Type: DAMD17-01-1-0100 Period: Sep. 17, 2001 to Oct. 16,2005
The major goal of this project is to test the innovative ideas of Smad-mediated signaling during prostate development using novel experimental technologies.

"Tobacco Alteration of TGF Beta3 Control of Palatogenesis"

Principal Investigator: Charles F. Shuler, D.M.D., Ph.D.
Agency: University of California-Tobacco Related Disease Research Program
Type: 11RT-0064, Period: July 01, 2002 to June 30, 2006
The major goal of this project is to examine the effects of tobacco products on the regulation of the TGF-beta3 signaling pathway in developing palatal tissues as an exemplar of the types of environmental teratogens that disproportionately affect minority populations in the Los Angeles region.

Publications

Sedghizadeh PP, Wong D, Shuler CF, Linz V, Kalmar JR, Allen CM. (2007). Multifocal calcifying epithelial odontogenic tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 104(2):e30-4.

Wuenschell CW, Dalrymple KR, and Shuler CF. (2007). PBL core skills faculty development workshop 2: Training faculty in group learning facilitation skills through role-modeling and role-play activities. Journal of Dental Education 71(5): 606-18

Dalrymple KR, Wuenschell C, Rosenblum A, Paine M, Crowe D, von Bergmann HC, Wong S, Bradford MS, Shuler CF. (2007). PBL core skills faculty development workshop 1: An experiential exercise with the PBL process. J Dent Educ. 71(2):249-59.

Nakajima A, Ito Y, Asano M, Maeno M, Iwata K, Mitsui N, Shimizu N, Cui XM, Shuler CF. (2007). Functional role of transforming growth factor-beta type III receptor during palatal fusion. Dev Dyn. 236(3):791-801.

Haghparast N, Sedghizadeh PP, Shuler CF, Ferati D, Christersson C. (2007). Evaluation of student and faculty perceptions of the PBL curriculum at two dental schools from a student perspective: a cross-sectional survey. Eur J Dent Educ. 11(1):14-22.

Kumar SK, Ram S, Jorgensen MG, Shuler CF, Sedghizadeh PP. (2006). Multicentric peripheral ossifying fibroma. J Oral Sci. 48(4):239-43.

Dalrymple KR, Wuenschell C, Shuler CF. (2006). Development and implementation of a comprehensive faculty development program in PBL core skills. J Dent Educ. 70(9):948-55.

Yamazaki K, Crowe DL, Shuler CF. (2006). Hunchback sequence binding protein suppresses mouse TGF-beta3 promoter in vitro. Biochem Biophys Res Commun.;346(3):802-9.

Shiomi N, Cui XM, Yamamoto T, Saito T, Shuler CF. (2006). Inhibition of SMAD2 expression prevents murine palatal fusion. Dev Dyn. 235(7):1785-93.

Shuler CF. (2005). Emerging scientific advances: how do they enter dental curricula and the profession? J Calif Dent Assoc. 33(10):805-9.

De S, Nguyen AQ, Shuler CF, Turman JE Jr. (2005). Mesencephalic trigeminal nucleus development is dependent on Krox-20 expression. Dev Neurosci. 27(1):49-58.

Rich SK, Keim RG, Shuler CF. (2005). Problem-based learning versus a traditional educational methodology: a comparison of preclinical and clinical periodontics performance. J Dent Educ. 69(6):649-62.

Chodankar R, Kwang S, Sangiorgi F, Hong H, Yen HY, Deng C, Pike MC, Shuler CF, Maxson R, Dubeau L. (2005). Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells. Curr Biol. 29;15(6):561-5.

Cui XM, Shiomi N, Chen J, Saito T, Yamamoto T, Ito Y, Bringas Jr. P, Chai Y, Shuler CF. (2005) Overexpression of Smad2 in TGF-beta3-null mutant mice rescues cleft palate. Dev. Biol. 278, 193-202.

Saito T, Cui XM, Yamamoto T, Shiomi N, Bringas Jr. P, Shuler CF. (2005) Effect of N′-nitrosonornicotine (NNN) on murine palatal fusion in vitro. Toxicology. 207(3):475-85

Saito T, Fukui K, Akutsu S, Nakagawa Y, Ishibashi K, Nagata J, Shuler CF, Yamane A. (2004). Effects of diet consistency on the expression of insulin-like growth factors (IGFs), IGF receptors and IGF binding proteins during the development of rat masseter muscle soon after weaning. Arch Oral Biol. 49(10):777-82.

Honma S, De S, Li D, Shuler CF, Turman JE Jr. (2004). Developmental regulation of connexins 26, 32, 36, and 43 in trigeminal neurons. Synapse. 52(4):258-71

Yamamoto T, Cui XM, Shuler CF. (2003). Role of ERK1/2 signaling during EGF-induced inhibition of palatal fusion. Dev Biol. 260(2):512-21

Ito Y, Yeo JY, Chytil A, Han J, Bringas P Jr, Nakajima A, Shuler CF, Moses HL, Chai Y. (2003). Conditional inactivation of TGF-beta IIR in cranial neural crest causes cleft palate and calvaria defects. Development 130, 5269-5280.

Cui XM, Chai Y, Chen J, Yamamoto T, Ito Y, Bringas P, Shuler CF. (2003). TGF-beta3-dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusion. Dev Dyn. 227:387-94.

Wu LY, Li M, Hinton DR, Guo L, Jiang S, Wang JT, Zeng A, Xie JB, Snead M, Shuler C, Maxson RE Jr, Liu YH. (2003). Microphthalmia Resulting from Msx2-Induced Apoptosis in the Optic Vesicle. Invest Ophthalmol Vis Sci 44, 2404-2412.

De S, Shuler CF, Turman JE. (2003). The ontogeny of Krox-20 expression in brainstem and cerebellar neurons. J Chem Neuroanat;25(3):213-26

Saito T, Akutsu S, Urushiyama T, Ishibashi K, Nakagawa Y, Shuler CF, Yamane A. (2003). Changes in the mRNA Expressions of Insulin-like Growth Factors, Their Receptors, and Binding Proteins during the Postnatal Development of Rat Masseter Muscle. Zoolog Sci;20(4):441-7

Shuler CF. (2002). Application of problem-based learning to clinical dental education. J Calif Dent Assoc;30(6):435-7, 440-3

Diekwisch TG, Berman BJ, Anderton X, Gurinsky B, Ortega AJ, Satchell PG, Williams M, Arumugham C, Luan X, McIntosh JE, Yamane A, Carlson DS, Sire JY, Shuler CF. (2002). Membranes, minerals, and proteins of developing vertebrate enamel. Microsc Res Tech;59(5):373-95

Satchell PG, Anderton X, Ryu OH, Luan X, Ortega AJ, Opamen R, Berman BJ, Witherspoon DE, Gutmann JL, Yamane A, Zeichner-David M, Simmer JP, Shuler CF, Diekwisch TG. (2002). Conservation and variation in enamel protein distribution during vertebrate tooth development. J Exp Zool 294(2):91-106

Yen SL, Gross J, Yamashita DD, Kim TH, McAndrews J, Shuler C, Reinisch J. (2002). Correcting an Anterior Open-Bite Side Effect during Distraction with Spring Forces. Plast Reconstr Surg, 110(6):1476-84

Sedghizadeh PP, Shuler CF, Allen CM, Beck FM, Kalmar JR. (2002). Celiac disease and recurrent aphthous stomatitis: A report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod;94(4):474-8

Shuler CF. (2001). Inherited risks for susceptibility to dental caries. J Dent Educ; 65(10):1038-45

Shuler CF. (2001). Keeping the curriculum current with research and problem-based learning. J Am Coll Dent 68(3):20-4

Ito Y, Zhao J, Mogharei A, Shuler CF, Weinstein M, Deng C, Chai Y (2001). Antagonistic effects of Smad2 versus Smad7 are sensitive to their expression level during tooth development. J Biol Chem 276(47):44163-44172

Yen SL, Shang W, Shuler C, Yamashita DD (2001). Orthodontic spring guidance of bilateral mandibular distraction in rabbits. Am J Orthod Dentofacial Orthop 120: 435-42

Turman JE Jr, Chopiuk NB, Shuler CF (2001). The krox-20 null mutation differentially affects the development of masticatory muscles. Dev Neurosci 23: 113-121

Fincham AG, Shuler CF (2001). The changing face of dental education: the impact of PBL. J Dent Educ 65: 406-421

Shuler CF, Dalrymple KR (2001). Molecular regulation of tongue and craniofacial muscle differentiation. Crit Rev Oral Biol Med 12: 3-17

Dalrymple KR, Prigozy TI, Shuler CF (2001). Embryonic, fetal, and neonatal tongue myoblasts exhibit molecular heterogeneity in vitro. Differentiation 66: 218-226

Yamane A, Mayo ML, and Shuler CF (2000). The Expression of insulin-like growth factor-I, II and their cognate receptor 1 and 2 during mouse tongue embryonic and neonatal development. Zoological Science 17: 935-945.

Stewart S, Yi S, Kassabian G, Mayo M, Sank A, Shuler CF (2000). Changes in expression of the lysosomal membrane glycoprotein, LAMP-1 in interdigital regions during embryonic mouse limb development, in vivo and in vitro. Anat Embryol 201: 483-490.

Cui XM, Shuler CF (2000). The TGF-b type III receptor is localized to the medial edge epithelium during palatal fusion. Int. J. Dev. Biol. 44: 379-420.

Mogass M, Bringas P, Shuler CF (2000). Characterization of desmosomal component expression during palatogenesis. Int. J. Dev. Biol. 44: 317-322.

Satchell PG, Shuler CF, Diekwisch TG (2000). True enamel covering in teeth of the Australian lungfish Neoceratodus forsteri. Cell Tissue Res 299:27-37.

Dalrymple KR, Prigozy TI, Mayo M, Kedes L, Shuler CF (1999). Murine tongue muscle displays a unique developmental profile of MRF and contractile gene expression. Int. J. Dev. Biol. 43: pp. 27-37.

Crowe DL, Milo GE, Shuler CF (1999). Keratin 19 Downregulation by oral squamous cell carcinoma lines increases invasive potential. J. Dent. Res. 78 (6): 1256-1263.

Crowe DL, Shuler CF (1999). Regulation of tumor cell invasion by extracellular matrix. Histol Histopathol. 14: 665-671.

Chai Y, Bringas P, Shuler CF, Devaney E, Grosschedl R, Slavkin HC (1998). A mouse mandibular culture model permits the study of neural crest cell migration and tooth development. Int. J. Dev. Biol. 42:87-94.

Crowe DL, Cui XM, Shuler CF (1998). Inhibition of acidic ribosomal phosphoprotein P1 expression reduces translational efficiency and cell proliferation of mouse embryo fibroblasts. Int J. Oral Biol. 23: pp. 83-90.

Crowe DL, Osaseri UE, Milo GE, Shuler CF (1998). Tumor suppressor function of a dominant negative retinoic acid receptor mutant. Molec. Carcinogenesis 22:26-33.

Cui XM, Warburton D, Zhao J, Crowe DL, Shuler CF (1998). Immunohistochemical localization of TGF-b type II receptor and TGF-b 3 during palatogenesis in vivo and in vitro. Int. J. Dev. Biol. 42:817-820.

Shuler CF, Fincham AG (1998). Comparitive achievement on National Dental Board Examination Part I between dental students in Problem-Based Learning and traditional educational tracks. J. Dent. Ed. 62: 666-670.

Chai Y, Bringas P, Mogharei A, Slavkin HC, Shuler CF (1998). PDGF-A and PDGFR-a regulate tooth formation via autocrine mechanism during mandibular morphogenesis in vitro. Dev. Dynamics 213: 500-511.

Crowe DL, Shuler CF (1998). Increased cdc2 and cdk2 kinase activity by retionoid X receiptor n -mediated transcriptional down-regulation of the cyclin-dependent kinase Inhibitor p21 correlates with terminal differentiation of squamous cell carcinoma Lines. Cell Growth & Differentiation. Vol. 9: pp. 619-627.

Shuler CF, Milo G.E (1997). Tumor cell phenotypes: Morphologic and molecular characterizations. Encyclopedia of Cancer, III: pp. 1868-1882.

Crowe DL, Shuler CF (1997). Translational inhibition enhances mRNA stability of the retinoid acid (RA) responsive keratin 18 gene expressed by oral squamous cell carcinoma lines but blocks RA dependent stabilization. In. J. Oral Biol. 22: 179-186.

Chai Y, Sasano Y, Bringas P, Mayo M, Kaartinen V, Groffen J, Heisterkamp N, Slavkin, HC, Shuler CF (1997). The characterization of the fate of midline epithelial cells during the fusion of mandibular prominences in vivo. Dev. Dynamics 208: 526-535.

Lee H, Li D, Prior T, Casto BC, Weghorst CM, Shuler CF, Milo GE ( 1997). Ineffectiveness of the presence of H-ras/p53 combination of mutations in squamous cell carcinomas cells to induce a conversion of a non-tumorigenic to a tumorigenic phenotype. Cell Biology and Toxicology 13(6) 419-434.

Kaartinen V, Cui XM, Heisterkamp N, Groffen J, Shuler CF (1997). Transforming growth factor b 3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane. Dev. Dynamics. 209: 255-260.

Prigozy T, Dalrymple K, Shuler CF, Kedes L (1997). Myogenic regulatory factor expression during craniofacial development. Dev. Dynamics. 209: 36-44.

Fincham AG, Baehner R, Chai Y, Crowe DL, Fincham C, Iskandar M, Landesman HM, Lee M, Luo W, Paine M, Pereira L, Moradian-Oldak J, Roseblum A, Snead ML, Thompson P, Wuenschell C, Zeichner-David M, Shuler CF (1997). Problem-based learning at the University of Southern California, School of Dentistry: A term report. J. Dent.Ed. 61: 417-425.

Chen J, Milo GE, Shuler CF, Schuller DE (1996). Xenograft growth and histodifferentiation of squamous cell carcinomas of the pharynx and larynx. Oral Surg. 81: 197-202.

Stafford DL, Lussier MR, Sank AC, Shuler CF (1995). In vitro model of syndactyly replicates the morphologic features observed in vivo. Plast. and Reconstruc. Surg. 96: 1169-1176.

Shuler CF (1995). Programmed cell death and cell transformation in craniofacial development. Crit. Rev. Oral Biol. Med. 6: 202-217.

Last Updated: 11/30/07