CCMB Faculty

CSA 207, HSC9062
(323) 442-3589 Voice
(323) 442-2981 Fax
slavkin@usc.edu

Harold C. Slavkin

D.D.S.

G. Donald & Marian James Montgomery Professor

Education Experience Honors & Awards Publications

Education

INSTITUTION AND LOCATION	DEGREE	YEAR(s)	FIELD OF STUDY
University of Southern California, Los Angeles, CA	B.S.	1961	English/Biology
University of Southern California, Los Angeles, CA	D.D.S.	1965	Dentistry
University of California, Los Angeles, CA	Postdoc.	1995-97	Anatomy
University of Southern California, Los Angeles, CA	Postdoc.	2000	Biochemistry

Research & Professional Experience

2009-present	G. Donald & Marian James Montgomery Professor of Dentistry, University of Southern California, Los Angeles, CA
2000-2008	Dean and G. Donald & Marian James Montgomery Professor of Dentistry, University of Southern California, Los Angeles, CA
1995-2000	Director, National Institute of Dental & Craniofacial Research, NIH
1995-2000	Lab Chief, Laboratory of Craniofacial Developmental Biology, NIAMS, NIH
1990-1995	George & Mary Lou Boone Professor of Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA
1987-1988	Lady Davis Professor, Technion-Israel Institute of Technology, Haifa, Israel
1979-1980	Visiting Scholar, Department of Anatomy & Embryology, University College London, United Kingdom
1975-1985	Chairman, Graduate Program in Craniofacial Biology, Graduate School, University of Southern California, Los Angeles, CA
1974-1995	Professor of Biochemistry, University of Southern California Dental School, Los Angeles, CA
1974-1975	Acting Lab Chief, Laboratory for Developmental Biology, NIDR, NIH

1972-1988	Lab Chief, Laboratory for Developmental Biology, University of Southern California, Los Angeles, CA
1971-1973	Associate Professor of Biochemistry, University of Southern California Dental School, Los Angeles, CA
1971-1973	Associate Professor of Biochemistry, University of Southern California Dental School, Los Angeles, CA
1968-1995	Faculty, Graduate Programs Cell & Molecular Biology, University of Southern California Graduate School, Los Angeles, CA
1968-1970	Assistant Professor of Biochemistry, University of Southern California Dental School, Los Angeles, CA

Academic Honors and Awards

2001	Fellow, American Association For The Advancement of Science (AAAS)
2001	Honorary Award, American Cleft Lip and Palate Association
2002	Honorary Doctor of Science Degree, University of Detroit Mercy School of Dentistry, Detroit, MI
1999	Honorary Doctor of Science Degree, Université de Montréal, Canada
1999	Honorary Doctor of Science Degree, University of Medicine and Dentistry of New Jersey, Newark, NJ
1999	Honorary Doctor of Science Degree, University of Connecticut Health Center, Farmington, CT
1997	Honorary Doctor of Science Degree, University of Maryland, Baltimore, Baltimore, MD
1996	Honoris Causa Award from the Universite de Paris Vth, France
1991	Craniofacial Biology Award, International Association For Dental Research
1990	Doctorate of Science (Honorary Degree), Georgetown University, Washington, DC

Selected Publications

Snead ML, Slavkin HC. (2009) Science is the fuel for the engine of technology and clinical practice. J Am Dent Assoc. 140 Suppl 1:17S-24S

Huang XF, Bringas P, Slavkin HC, Chai Y. (2009) Fate of HERS during Tooth Root Development. Dev. Biol. 334(1):22-30

Shi S, Chai Y, Slavkin H. (2009) Emerging opportunities for the next generation of dental implants? Dent Today 28(3):98-9.

Slavkin HC, Navazesh M, Patel P. (2008) Basic principles of human genetics: a primer for oral medicine. In Burket’s Oral Medicine. 11th edition (eds. Greenberg M, Glick M, Ship J) Hamilton, Ontario: BC Decker Inc. pp 549-568.

Murashima-Suginami A, Takahashi K, Sakata T, Tsukamoto H, Sugai M, Yanagita M, Shimizu A, Sakurai T, Slavkin HC, Bessho K. (2008) Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse. Biochem Biophys Res Commun. 369(4):1012-6.

Slavkin HC, Lawrence L. (2007). Incorporating leadership knowledge and skills into the dental education community. J Dent Educ. 71(6):708-12.

Murashima-Suginami A, Takahashi K, Kawabata T, Sakata T, Tsukamoto H, Sugai M, Yanagita M, Shimizu A, Sakurai T, Slavkin HC, Bessho K. (2007) Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation. Biochem Biophys Res Commun. 359(3):549-55.

Slavkin HC, Bartold PM. (2006). Challenges and potential in tissue engineering. Periodontol 2000. 41:9-15.

Sasaki T, Ito Y, Bringas Jr. P, Chou S, Urata M, Slavkin HC, Chai Y. (2006). TGF-beta-mediated FGF signaling is critical for regulating cranial neural crest cell proliferation during frontal bone development. Development 133, 371-381

Slavkin HC. (2005). Dental student research: helping to shape the future. J Calif Dent Assoc. 33(12):945.

Sasaki T, Ito Y, Xu X, Han J, Bringas Jr P, Maeda T, Slavkin HC, Grosschedl R, Chai Y. (2005) LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev. Biol. 278,130-143.

Tan, DP, Nonaka, K, Nuckolls, GH, Liu, YH, Maxson, RE, Slavkin, HC, Shum, L. (2002). YY1 activates Msx2 gene independent of bone morphogenetic protein signaling. Nucleic Acids Res. 30:1213-1223.

Ayres, J.A., Shum, L., Akarsu, N., Dasher, R., Takahashi, K., Ikura, T., Slavkin, H.C., and Nuckolls, G. (2001). DACH: Genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the murine homologue. Genomics. 77(1): 18-26.

Takahashi, K, Nuckolls, GH, Takahashi, I, Nonaka, K, Nagata, M, Ikura, T, Slavkin, HC, Shum, L. (2001). Msx2 is a repressor of chondrogenic differentiation in migratory cranial neural crest cells. Develop. Dynamics 222:252-262.

Semba I, Nonaka K. Takahashi I, Takahashi K, Dashner R, Shum L, Nuckolls G.H., and Slavkin, H.C. (2000). Positionally-dependent chondrogenesis induced by BMP4 is co-regulated by Sox9 and MSX2. Develop. Dynamics. 217:401-414.

Nonaka K, Shum L, Takahashi I, Takahashi K, Ikura T, Dashner R, Nuckolls G.H., Slavkin, H.C. (1999). Convergence of the BMP and EGF Signaling Pathways on Smad1 in the Regulation of Chrondrogenesis. Int. J. of Develop. Biol. 43:795-807

Kobayashi S, Satomura K, Levsky J.M., Sreenath T, Wistow G.J., Semba I, Shum L, Slavkin HC, and Kulkarni A.B. (1999). Expression Pattern of Macrophage Migration Inhibitory Factor During Embryogenesis. Mechanisms of Development 84:153-156.

Miettinen PJ, Chin JR, Shum L, Slavkin HC, Shuler C, Derynck R, and Werb Z. (1999). Epidermal Growth Factor Receptor Function is Necessary for Craniofacial Development and Palate Closure. Nature Genetics. 22:69-73.

Nuckolls G.H., Shum L., Slavkin H.C. (1999). Progress Towards Understanding Craniofacial Malformations. The Cleft Palate Craniofacial Journal. 36(1)12-26.

Takahashi I, Nuckolls GH, Takahashi K, Tanaka O, Semba I, Dashner R, Shum L, and Slavkin HC. (1998). Compressive Force Induces Sox9, Type II Collagen and Aggrecan and Inhibits IL1-β Expression Resulting in Chondrogenesis in Mouse Embryonic Limb Bud Mesenchymal Cells. J. Cell Sci. 111:2067-2076.

Takahashi K, Nuckolls G, Tanaka O, Semba I, Takahashi I, Dashner R, Shum L, Slavkin, H.C. (1998). Adenovirus Mediated Ectopic Expression of Mxs2 in Even-Numbered Rhombomeres Induces Apoptotic elimination of Cranial Neural Crest Cells in Ovo. Development. 125:1627-1635

Sadler TW, Melissa R, Slavkin HC, Lauder J, Maness P, Linney E, Sulik K, Mirkes P. (1997). Growth and Differentiation Factors. Reproductive Toxicology 11(2-3): 331-337

Chai Y, Sasano Y, Bringas P Jr., Mayo M, Slavkin H.C., Shuler, C. (1997). Characterization of the Fate of Medial Epithelial Cells During the Fusion of Mandibular Prominances in vivo. Developmental Dynamics 208:526-535

Chai, Y., Mah, A., Crohin, C., Groff, S., Bringas, P., Le, T., Santos, V. and Slavkin, H. C. (1994). Specific transforming growth factor-beta subtypes regulate embryonic mouse Meckel's cartilage and tooth development. Develop. Biol. 162:85-103.

Shum, L., Sakakura, Y., Bringas, Jr., P., Luo, W., Snead, M. L., Mayo, M., Crohin, C., Millar, S., Werb, Z., Buckley, S., Hall, F.L., Warburton, D. and Slavkin, H.C. (1993). EGF abrogation induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro. Development, 118:903-917.

Slavkin, H.C. (1993). Reigers syndrome revisited: Experimental approaches using pharmocologic and antisense strategies to abrogate EGF and TGF-alpha functions resulting in dysmorphogenesis during embryonic mouse craniofacial morphogenesis. Am. J. of Med. Genetics, 47:689-697.

Ferguson, M.W.J., Honig, L.S. and Slavkin, H.C. (1984). Differentiation of cultural palatal shelves from alligator, chick, and mouse embryos. Anat. Rec. 209(2): 231-249.

Slavkin, H.C., Bringas, P., Jr., Cummings, E. and Grodin, M.S. (1982). Initiation of quail and mouse mandibular chondrogenesis and osteogenesis in a serumless, chemically-defined medium. Calcif. Tissue. Int. 34:111-112.

Melnick, M., Jaskoll, T. and Slavkin, H.C. (1981). Corticosteriod-induced cleft palate in mice and H-2 haplotype material and embryonic effects. Immunogenetics, 13:443-450.

Melnick, M., Jaskoll, T. and Slavkin, H.C. (1981). The association of H-2 haplotype with implantation, survival, and growth of murine embryos. Immunogenetics, 14:303-308.

Last Updated: 10/07/09