CCMB Faculty

CSA 141, HSC 9062
(323)442-1759 Voice
(323)442-2981 Fax
joldak@usc.edu

Janet Moradian-Oldak

M.Sc., Ph.D.

Associate Professor

News Links

CCMB Scientists Answer Key Enamel Question

A Sense of Place

The Regeneration of Tooth Enamel

Education Experience Honors & Awards Projects Current Research Publications Book Chapters

Education

INSTITUTION AND LOCATION	DEGREE	YEAR(s)	FIELD OF STUDY
University of Southern California, USA	Post Doc	1992-95	Enamel Protein Biochemistry
Weizmann Institute of Science, Israel	Ph.D.	1992	Structural Biology
Weizmann Institute of Science, Israel	M.Sc.	1986	Structural Chemistry
Ben Gurion University, Israel	B.S.	1984	Chemistry

Research & Professional Experience

2007-Present	Associate Professor, Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA
2003-2007	Assistant Professor, Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA
1995-2002	Research Assistant Professor, Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA
1992-1995	Research Associate, Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA
1983	Chemical Analysis and Industrial Research, Development of Energy Sources

Academic Honors and Awards

2001	NIH/NIDCR R01 DE13414, Maxtrix-Based Mineral (MBM) Enamel Biomimetics, Principal Investigator
1998	Invited speaker; Gordon Conference on Biomineralization
1998	Young Investigators Award, Sixth International Conference on the Chemistry and Biology of Mineralized Tissues, Vittel, France
1997	NIH/NIDCR R29 DE12350, Amelogeuin processing and control of crystal growth, Principal Investigator
1996	Ciba Foundation Bursary , Dental Enamel, Symposium #205

Research Projects

“Intrinsically Disordered Proteins in Biomineralization”

Principal Investigator: Janet Moradian-Oldak, Ph.D.
Sponsor: National Institute of Dental Research
Period: 9/25/2009-08/31/2014
The long term objective of the proposed research is to advance understanding of the role of extracellular matrix protein fragmentation in enamel and dentin, with a focus on the analysis of folding and the degree of disorder in the secondary structures of key proteins and polypeptides.

“The Kinetics of Mineralization of Teeth”

Principal Investigator: Janet Moradian-Oldak, Ph.D.
Sponsor: SUNY at Buffalo / National Institute of Dental Research
Period: 5/15/2008-4/30/2013
The proposed research aims to improve understanding of mineralization and demineralization of teeth. The earliest nucleation events of mineralization during development of enamel, dentin and bone will be investigated at kinetic and molecular levels in solutions or at organic template surfaces. Dr. Moradian-Oldak will help with the biochemistry, physical chemistry and structure of amelogenin. She will further consult the overall preparation and handling of proteins and peptides for experiments proposed in aims II and III.

"Maxtrix-Based Mineral (MBM) Enamel Biomimetics"

Principal Investigator: Janet Moradian-Oldak, Ph.D.
Sponsor: National Institute of Dental Research
Period: 8/01/2001-1/31/2012
The major goal of this project is to understand the general principles that apply to the formation of matrix-based mineral (MBM).

"Action and Function of MMP-20 during Enamel Formation"

Principal Investigator: Janet Moradian-Oldak, Ph.D.
Sponsor: National Institute of Dental and Craniofacial Research
Period: 9/01/2005-6/30/2009
This research project will contribute to the basic knowledge required for the design and development of novel biomaterials with potential future application in clinical dentistry and other areas of biomedical and biomaterial technology

"Amelogenin Processing and its Correlation with Apatite Crystal"

Principal Investigator: Janet Moradian-Oldak, Ph.D.
Agency: National Institute of Dental Research
Type: R29 (DE12350-01A1, Years 1-5) Period: April 1, 1998 to March 31, 2003
The major goal of this project is to examine the hypothesis: Activity of "ameloprotease-I" correlates with the formation and maturation of enamel apatite crystals. Ameloprotease-I activation occurs in the extracellular matrix through proteolysis of its precursors. Amelogenin processing includes adsorption and dissociation of the substrate (amelogenin) and the proteinase (ameloprotease-I) onto apatite crystals.

"A New Strategy for Amelogenin Crystallization"

Principal Investigator: Janet Moradian-Oldak, Ph.D.
Sponsor: National Institute of Dental and Craniofacial Research
Period: 9/01/2003-6/30/2005
The major goal of this project is to develop and characterize surfaces for amelogenin adsorption in a monomeric state, which will be used for its crystallization, using Optical Wavelength Light Spectroscopy (OWLS), Scanning Angle Reflectometry (SAR) and Ellipsometry; and to carry out crystallization trails of amelogenin on a series of substrates as active nucleant surfaces to obtain X-ray diffraction quality single crystals.

Biomineralization Biomineralization involves the formation of minerals by organisms. It is therefore a multidisciplinary field that includes many areas in both the chemical and biological sciences. The members of all five kingdoms form more than 60 different minerals. The unique structure and orientation of crystals within the inorganic phases of mineralized tissues and in some cases the distinguished morphology of these biominerals are clear indications that the processes of crystal nucleation and growth are highly controlled by the organisms. Organisms use macromolecules such as proteins and glycoproteins to control these molecular processes.

Enamel Biomineralization and Amelogenin Proteins Bone and teeth are the classic example of apatitic mineralized tissues. In the case of tooth enamel, the mineralizing tissue generates the most unusual morphology of the carbonate-apatite (dahllite) crystals formed in biological hard tissues. Mature enamel contains crystals that are tens of microns long with an aspect ratio (length/width) of at least 1000. Only under extreme temperature and pressure conditions large dahllite crystals of up to 3.7 mm in length with a much smaller aspect ratio have been synthetically grown. Enamel extracellular matrix contains proteins, glycoproteins and proteinases. Amelogenin proteins, which are secreted by the inner enamel epithelium (ameloblasts), are hydrophobic in nature and are believed to function as the scaffold for the initiation and growth of enamel apatite crystals. After cloning of the amelogenin cDNA in 1985 and the subsequent expression of a recombinant form in 1994, the progress in the understanding of amelogenin biochemsitry and quaternary structure have been significant. One of the most recent and significant findings on amelogenin structure was that the molecules self-assemble to generate "nanosphere structures" of 1-20 nm in diameter which have been identified as the principle structural components of the secretory-stage enamel matrix (Moradian-Oldak et al 1994,1995, Fincham et al 1995). This finding had a remarkable impact on the research of several other laboratories studying mineralized tissues.

Current Research Activities

My research activities under currently funded NIH grants will involve the disciplines of protein chemistry, inorganic chemistry, biochemistry, molecular biology, structural biology and protein-mineral interactions. My research activities on amelogenin proteolysis, structure and function are aimed to advance understanding of the fundamental mechanisms of molecular interactions involved in the formation of dental enamel. The molecular mechanisms considered include amelogenin-amelogenin, amelogenin-proteinase, and amelogenin-mineral interactions. The outcomes of these studies will contribute insight into biomineralization mechanisms in general and will provide scientific basis for the design and development of novel biomaterials. During enamel maturation, massive processing and removal of the matrix is concomitant with the rapid growth and maturation of enamel crystallites. There are speculations that the stepwise processing of amelogenins is one of the key factors in controlling some processes of crystal growth. In my first independent grant (NIH-R29) I have proposed to investigate the mechanisms of action of enamel proteinases (enamelysin and EMSP1) and their correlation to apatite crystal growth. In general, the concept that activity of proteinases can be influenced by the presence of mineral is novel and I believe that certain general principles can be explored based on enamel model.

My second NIH grant (R01) deals with the structure and function of enamel proteins; (i.e. hydrophobic amelogenins and acidic enamelins). Following the description of amelogenin "nanosphres" by Fincham A.G. and Moradian-Oldak J, and the study of amelogenin self-assembly properties, I plan to investigate the influence of other enamel proteins on the assembly of amelogenin nanopshres. We apply dynamic light scattering, atomic force microscopy, transmission electron microscopy and high performance liquid chromatography to analyze the assembly properties of these proteins a well as their interactions with apatite mineral. Currently, together with my Post Doctoral fellow we design experiments for examining the influence of enamel proteins on the kinetics of apatite crystal nucleation and their effect on growth morphology. Expression, isolation and purification of proteins both in recombinant form and from in vivo sources are important steps that are included in my research activities.

Publications

Sun Z, Carpiaux W, Fan D, Fan Y, Lakshminarayanan R, Moradian-Oldak J. (2009) Apatite reduces amelogenin proteolysis by MMP-20 and KLK4 in vitro. J. Den. Res. In Press

Lakshminarayanan R, Yoon I, Hegde BG, Fan D, Du C, Moradian-Oldak J. (2009) Analysis of Secondary Structure and Self-Assembly of Amelogenin by Variable Temperature Circular Dichroism and Isothermal Titration Calorimetry. Proteins: Structure Function. Bioinformatics. 76(3):560-9

Fan Y, Sun Z, Moradian-Oldak J (2009) Effect of fluoride on the morphology of calcium phosphate crystals grown on acid etched human enamel. Caries Research. 43(2):132-6

Delak K, Harcup C, Lakshminarayanan R, Zhi S, Fan Y, Moradian-Oldak J, Evans JS. (2009) The tooth enamel protein, porcine amelogenin, is an intrinsically disordered protein with an extended molecular configuration in the monomeric form. Biochemistry, 48(10):2272-2281

Fan D, Du C, Sun Z, Lakshminarayanan R, Moradian-Oldak J. (2009) Interaction between the 32 kDa Porcine Enamelin and Amelogenin. Journal of Structural Biology. 166(1):88-94

Du C, Fan D, Sun Z, Fan Y, Lakshminarayanan R, Moradian-Oldak J. (2009). Immunogold Labeling of Amelogenin in Developing Porcine Enamel Revealed by Field Emission Scanning Electron Microscopy. Cells Tissues Organs. 189(1-4):207-11

Fan Y, Sun Z, Moradian-Oldak J. (2009) Controlled remineralization of enamel in the presence of amelogenin and fluoride. Biomaterials. 30(4):478-83

Sun Z, Fan D, Fan Y, Du C, Moradian-Oldak J. (2008) Enamel Proteases Reduce Amelogenin-Apatite Binding. J. Den. Res. 87(12):1133-7

Wang L, Guan X, Yin H, Moradian-Oldak J, Nancollas GH. (2008) Mimicking the self-organized microstructure of tooth enamel. J. Physical Chem C. 112: 5892-99

Fan D, Lakshminarayanan R, Moradian-Oldak J. (2008). The 32kDa enamelin undergoes conformational transitions upon calcium binding. J Struct Biol. 163(1):109-15.

Lakshminarayanan, R., Daming Fan, Chang Du, and Moradian-Oldak, J. (2007) The role of secondary structure in the entropically driven amelogenin self-assembly. Biophysical Journal 93, 3664-3674.

Fan YW, Sun Z, Wang RZ, Abbott C, Moradian-Oldak J. (2007). Enamel inspired nano-composite fabrication through amelogenin supramolecular assembly. Biomaterials, 28(19):3034-42

Moradian-Oldak J (2007). The emergence of "nanospheres" as basic structural components adopted by amelogenin. J Dent Res 86(6):487-90.

Du C, Moradian-Oldak J. (2006) Tooth regeneration: challenges and opportunities for biomedical material research. Biomed Mater. 1(1):R10-7. Review.

Bartlett JD, Ganss B, Goldberg M, Moradian-Oldak J, Paine ML, Snead ML, Wen X, White SN, Zhou YL. (2006). Protein-protein interactions of the developing enamel matrix. Curr Top Dev Biol. 74:57-115.

Moradian-Oldak J, Wen HB, Schneider GB, Stanford CM. (2006). Tissue engineering strategies for the future generation of dental implants. Periodontol 2000. 41:157-76.

Petta V, Moradian-Oldak J, Yannopoulos SN, Bouropoulos N. (2006) Dynamic light scattering study of an amelogenin gel-like matrix in vitro. Eur J Oral Sci. 114 Suppl 1:308-14; discussion 327-9, 382.

Iijima M, Du C, Abbott C, Doi Y, Moradian-Oldak J. (2006) Control of apatite crystal growth by the co-operative effect of a recombinant porcine amelogenin and fluoride. Eur J Oral Sci. 114 Suppl 1:304-7; discussion 327-9, 382.

Moradian-Oldak J, Du C, Falini G. (2006) On the formation of amelogenin microribbons. Eur J Oral Sci. 114 Suppl 1:289-96; discussion 327-9, 382.

Sun Z, Ahsan MM, Wang H, Du C, Abbott C, Moradian-Oldak J. (2006) Assembly and processing of an engineered amelogenin proteolytic product (rP148). Eur J Oral Sci.;114 Suppl 1:59-63; discussion 93-5, 379-80.

Moradian-Oldak J. & Goldberg M. (2005). Amelogenin supra-molecular assembly in vitro compared to the architecture of the forming enamel matrix. Cells Tissue Organs. 181:202-218.

Du C, Schneider GB, Zaharias R, Abbott C, Seabold D, Stanford C, Moradian-Oldak J. (2005). Apatite/amelogenin coating on titanium promotes osteogenic gene expression. J Dent Res. 84(11):1070-4.

Du C, Falini G, Fermani S, Abbott C, Moradian-Oldak J. (2005). Supramolecular Assembly of Amelogenin Nanospheres into Birefringent Microribbons. Science, Vol 307, Issue 5714, 1450-1454

Iijima M, Moradian-Oldak J. (2005). Control of apatite crystal growth in a fluoride containing amelogenin-rich matrix. Biomaterials. 26(13):1595-603

Iijima M, Moradian-Oldak J. (2004). Control of octacalacium phosphate and apatite crystal growth by amelogenin matrices. J. Mat. Chem. 14,2189-2199

Bouropoulos N, Moradian-Oldak J. (2004). Induction of apatite by the cooperative effect of amelogenin and the 32-kDa enamelin. J Dent Res.;83(4):278-82.

Iijima M, Moradian-Oldak J. (2004). Interactions of Amelogenins with Octacalcium Phosphate Crystal Faces Are Dose Dependent. Calcif Tissue Int. 74(6):522-31

Moradian-Oldak J, Iijima M, Bouropoulos N, Wen HB. (2003). Assembly of amelogenin proteolytic products and control of octacalcium phosphate crystal morphology. Connect Tissue Res. 44 Suppl 1:58-64.

Bouropoulos N, Moradian-Oldak J. (2003). Analysis of Hydroxyapatite Surface Coverage by Amelogenin Nanospheres Following the Langmuir Model for Protein Adsorption. Calcif Tissue Int 72(5):599-603

Wen HB, Moradian-Oldak J. (2003). Modification of calcium-phosphate coatings on titanium by recombinant amelogenin. J Biomed Mater Res; 64A(3):483-490

Moradian-Oldak J, Gharakanian N, Jimenez I. (2002). Limited proteolysis of amelogenin: Toward understanding the proteolytic processes in enamel extracellular matrix. Connect Tissue Res. 43(2-3):450-5

Wang L, Moradian-Oldak J. (2002). Assessment of Enamelysin (MMP-20) Selectivity to Three Peptide Bonds on Amelogenin Sequence. J Dent Res. 81(10):664-7

Moradian-Oldak J, Bouropoulos N, Wang L, Gharakhanian N. (2002). Analysis of self-assembly and Apatite binding properties of amelogenins lacking the hydrophiliv C-terminal. Matrix Biology 21: 197-205.

Iijima M, Moriwaki Y, Wen HB, Fincham AG, Moradian-Oldak J (2002). Elongated growth of octacalcium phosphate crystals in recombinant amelogenin gels under controlled ionic flow. J Dent Res 81: 69-73

Wen HB, Fincham AG, Moradian-Oldak J (2001). Progressive accretion of amelogenin molecules during nanospheres assembly revealed by atomic force microscopy. Matrix Biology 20, 387-395.

Moradian-Oldak J (2001). Amelogenins: Assembly, processing and control of crystal morphology. Matrix Biology, 20, 293-305.

Moradian-Oldak J, Jimenez I, Maltby D, Fincham AG (2001). Controlled Proteolysis of Amelogenins Reveals Exposure of both Carboxy- and Amino-Terminal Regions. Biopolymers, 58, 606-616.

Iijima M, Moriwaki1 Y, Takagi T, Moradian-Oldak J (2001). Effects of bovine amelogenins on the crystal morphology of octacalcium phosphate in a model system of tooth enamel formation. J Crystal growth , 222, 615-626.

Wen HB, Moradian-Oldak J, Fincham AG (2000). Dose dependent modulation of octacalcium phosphate crystal habit by amelogenins. J Dent Res 79:1902-1906

Wen HB, Moradian-Oldak J, Zhong JP, Greenspan DC, Fincham AG (2000). Effects of amelogenin on the transforming surface microstructure of Bioglass in calcifying solution. J. Biomedical Material Res. 52(4), 762-773

Moradian-Oldak J, Paine ML, Lei YP, Fincham AG, Snead ML (2000). Self-assembly properties of recombinant engineered amelogenin proteins analyzed by dynamic light scattering and atomic force microscopy. J Struct. Biol., 131, 27-37.

Fincham AG, Moradian-Oldak J, Simmer JP (1999). The structural biology of the developing dental enamel matrix. J. Struct. Biology., 126, 270-299.

Ravindranath MH, Moradian-Oldak J, Fincham AG (1999). Tyrosyl motif in amelogenins binds N- acetyl-D-Glucosamine. J. Biol. Chem. 274:2464-2471.

Wen HB, Moradian-Oldak J, Fincham AG (1999). Modulation of apatite crystal growth on bioglass by recombinant amelogenin. Biomaterials., 20, 1717-1725.

Wen HB, Moradian-Oldak J, Leung W, Bringas P, Fincham AG (1999). Microstructures of an amelogenin gel matrix. J. Struct. Biol., 126, 42-51.

Fincham AG, Leung W, Tan J, Moradian-Oldak J (1998). Does amelogenin nanospheres assembly proceed through intermediately-sized structures? Connect Tissue Res 38: 237-240

Lyaruu DM, Hu CC, Zhang C, Qian Q, Ryu OH, Moradian-Oldak J, Woltgens JH, Fincham AG, Simmer JP (1998). Derived protein and cDNA sequences of hamster amelogenin. Eur J Oral Sci 106, 299-307.

Moradian-Oldak J, Leung W, Tan J, Fincham AG (1998). Effect of apatite crystals on the activity of amelogenin degrading enzymes. Connect. Tissue Res. 39, 131-140.

Moradian-Oldak J, Leung W, Fincham AG (1998). Temperature and pH-dependent supramolecular self-assembly of amelogenin molecules: a dynamic light-scattering analysis. J. Struct. Biol. 122, 320-327.

Moradian-Oldak J, Tan J, Fincham AG (1998). Interaction of Amelogenin with Hydroxyapatite Crystals; an Adherence Effect Through Amelogenion Molecular Self-Association. Biopolymers, 46, 225-238.

Ryu OH, Hu CC, Zhang C, Qian Q, Moradian-Oldak J, Fincham AG (1998). Proteolytic Activity of Oppossum Tooth Extract. Eur. J. Oral Sci. , 106, 337-344.

Tan J, Leung W, Moradian-Oldak J, Zeichner-David M, Fincham AG (1998). The pH dependent amelogenin solubility and its biological significance. Connect Tissue Res. 38: 215-21

Tan J, Leung W, Moradian-Oldak J, Zeichner-David M, Fincham AG (1998). Quantitative analysis of amelogenin solubility. J. Dent. Res ,77(6), 1388-1396.

Fincham AG, Baehner R, Chai Y, Crowe DL, Fincham C, Iskander M., Landesman HM, Lee M, Luo W, Paine M, Pereira L, Moradian-Oldak J, Rosenblum A, Snead ML, Thompson P, Wuenschell CW, Zeichner-David M, Shuler CF (1997). Problem-based Learning at the University of Southern California School of Dentistry. J. Dent Edu , 61, 417-425.

Hu CC, Zhang C, Qian Q, Ryu OH, Moradian-Oldak J, Fincham AG, Simmer JP (1996). Cloning, DNA sequence, and alternative splining of Opossum Amelogenin mRNAs. J. Dent. Res. 75 (10), 1728-1734.

Fincham AG, Moradian-Oldak J (1996). A comparative mass spectrometric analyses of enamel matrix proteins from four different species suggest a common pathway of post-proteolytic processing. Connect Tiss Res, 35, 151-156.

Moradian-Oldak J, Leung W, Simmer JP, Zeichner-David M, Fincham AG (1996). Identification of a novel proteinase "Ameloprotease I" responsible for complete degradation of amelogenin during enamel maturation. Biochem J. 318, 1015-1021.

Moradian-Oldak J, Sarte PE, Fincham AG (1996). Description of Two Classes of Proteinases From Enamel Extracellular Matrix Cleaving A Recombinant Amelogenin. Connect. Tiss. Res., 35, 231-238.

Fincham AG, Moradian-Oldak J (1995). Recent advances in amelogenin biochemistry. Connect. Tiss. Res. ,32, (# 1-4),119-124.

Fincham AG, Moradian-Oldak J, Diekwisch TG, Layaruu DM, Wright JT, Bringas P, Slavkin HC (1995). Evidence for a amelogenin "nanospheres" as functional components of secretory-stage enamel matrix. J. Struct. Biol. 115, 50-59.

Moradian-Oldak J, Simmer JP, Lau EC, Diekwisch TG, Slavkin HC, Fincham AG (1995). A review on the aggregation properties of a recombinant amelogenin. Connect. Tiss. Res. , 32, (# 1-4), 125-130.

Fincham AG, Moradian-Oldak J, Sarte PE (1994). Mass-Spectrographic analysis of a porcine amelogenin identifies a single phosphorylated locus. Calcif. Tiss. Intl 55, 398-400.

Fincham AG, Moradian-Oldak J, Simmer JP, Sarte PE, Lau EC, Diekwisch TG, Slavkin HC (1994). Self-Assembly of a recombinant amelogenin protein generates supramolecular structures. J. Struct. Biol. , 112, 103-109

Furedi-Milhofer H, Moradian-Oldak J, Veis A, Weiner S, Mintz K, Addadi L (1994). Interactions of matrix proteins from mineralized tissues with octacalcium phosphate and carbonate apatite. Connect. Tissue Res. 30: 251-64.

Moradian-Oldak J, Simmer JP, Lau EC, Sarte PE, Slavkin HC, Fincham AG (1994). Detection of monodisperse aggregates of a recombinant amelogenin by dynamic light scattering. Biopolymers, 34, 1339-1347.

Moradian-Oldak J, Simmer JP, Sarte PE, Zeichner-David M, Fincham AG (1994). Specific cleavage of a recombinant murine amelogenin at the carboxy-terminal region by a proteinase fraction isolated from developoing bovine tooth enamel .Archs. oral Biol.,39, 647-656.

Fincham AG, Moradian-Oldak J (1993). Amelogenin post-translational modification : Carboxy-terminal processing and the phosphorylation of bovine and porcine "TRAP" and "LRAP" amelogenins. Biochem. Biophys. Res. Comm. 197, 248-255.

Moradian-Oldak J, Frolow F, Addadi L, Weiner S (1992). Interactions between acidic matrix macromolecules and calcium phosphate ester crystals; Relevance to carbonate apatite formation in biomineralization. Proc. R. Soc. Lond (B), 247, 47-55.

Landis WJ, Moradian-Oldak J, Weiner S (1991). Topographic imaging of mineral and collagen in the calcifying turkey tendon. Connect. Tissue Res, 25, 181-196.

Moradian-Oldak J, Weiner S, Addadi L, Landis WJ, Traub W (1991). Electron diffraction study of individual crystals of bone, mineralized tendon and synthetic carbonate apatite. Connect. Tiss. Res., 25, 219-228.

Addadi L, Berman A, Moradian-Oldak J, Weiner S (1990). Tuning of crystal nucleation and growth by proteins: Molecular interactions at solid-liquid interfaces in biomineralization. Croatica Chimica Acta, 63, 539-544.

Addadi L, Berman A, Moradian-Oldak J, Weiner S (1989). Structural and Stereochemical relations between acidic macromolecules of organic matrices and crystals. Connect. Tiss. Res., 21, 127-135.

Addadi L, Moradian J, Shay E, Maroudas N, Weiner S (1987). A chemical model for the cooperation of sulfate and carboxylate in calcite crystal nucleation. Relevance to biomineralization. Proc. Nat. Acad. Sci. 84, 2732-2736.

Book Chapters

Moradian-Oldak, J., and Paine, M.L. (2008). Mammalian enamel formation. In “Biomineralization. From Nature to Application” Vol. 4 of ‘Metal Ions in Life Sciences’, (Eds. Sigel, A., Sigel, H., and Sigel, R.K.O.) John Wiley and Sons, Ltd., Chichester, UK, pp. 507-546.

Moradian-Oldak J, Wen HB, Fincham AG, Iijima M (2000). Amelogenin Nanospheres Modulate Crystal Habit of Octacalcium Phosphate and Hydroxyapatite Crystals in In Vitro Model Systems. In: Morphology and Dynamics of Crystal Surfaces in Complex Molecular Systems. Proceedings of the 2000 Spring Meeting Material Research Society, San Francisco, CA. (J.D. Yoreo, W. Casey, A. Malkin, E. Vlieg, M. Ward, Eds). MRS, Warrendale, Pennsylvania.

Fincham AG, Moradian-Oldak J, Paine ML, Snead ML, Zeichner-David M (2000). Enamel Biomineralization: The assembly and disassembly of an extracellular organic matrix. In Ferguson MWJ, Teaford M & Meredith-Smith (eds). Development, Function and Evolution of Teeth, Cambridge University Press, UK.

Wen HB, Moradian-Oldak J, Fincham AG, de Groot K (1999). Crystal Growth of calcium phosphate on biomaterilas. "Recent Research Developments, Crystal Growth Research Series, (S.G.Pandalai, Ed.) 1, 51-65.

Addadi L, Moradian-Oldak J, Furedi-Milhofer H, Weiner S, Veis A (1992). Stereochemical aspects of crystal regulation in calcium-associated mineralized tissues: Proceeding of Fourth International Conference on Chemistry and Biology of Mineralized Tissues . (H.C. Slavkin & P. Price Eds.).

Addadi L, Moradian-Oldak J, Weiner S (1991). Macromolecule-crystal recognition in biomineralization: Studies using synthetic polycarboxylate analogs: Surface reactive peptides and polymers, discovery and commercialization. ACS Symposium Series 444, (C. Steven Sikes & A.P.Wheeler), pp. 13-27.

Last Updated: 10/21/09