CCMB Faculty

CSA 104, HSC 9062
(323)442-3805 Voice
(323)442-2981 Fax
mattlee@usc.edu

Matthew K. Lee

M.D.

Research Assistant Professor

Education Experience Honors & Awards Projects Publications Abstracts

Education

INSTITUTION AND LOCATION	DEGREE	YEAR(s)	FIELD OF STUDY
University of Chicago, Chicago, Illinois	M.D.	1986	Medicine
University of Illinois, Chicago, Illinois	B.Sc.	1982	Bioengineering

Research & Professional Experience

1993-present	Research Assistant Professor, Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA
1994	Graduate, Physiology: Molecular and Cellular Biology, Marine Biological, Laboratory, Woods Hole MA
1992-1993	Research Associate, Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA
1993	Board Certification in Neonatology, American Board of Pediatrics
1991	Board Certification in General Pediatrics, American Board of Pediatrics
1989-1992	Fellowship in Neonatology, University of Washington
1986-1989	Internship/Residency in Pediatrics, Stanford University
1978-1982	Edmund James Honors Scholar, University of Illinois at Chicago

Academic Honors and Awards

1994	American Lung Association of California Research Grant
1993	Clinical Investigator Award, NIH National Heart, Lung, and Blood Institute

Research Projects

"How Does Androgen Inhibit Fetal Lung Maturation"

Principal Investigator: Matthew Lee
Sponsor: NIH/New England Medical Centers, Inc. (Subcontract)
Period: 03/03/2007-02/28/2011
The major goal of this project is to determine how dihydrotestosterone treatment regulates growth factor-stimulated p42/p44 Erk MAP kinase activation in primary mouse lung cells.

"Developmental Signal Integration by Fetal Lung "

Principal Investigator: Matthew Lee
Sponsor: National Heart, Lung, and Blood Institute
Period: 02/01/2000-01/31/2007
The major goals of this project are to determine if physiologically relevant changes in the relative expression of Shc isoforms regulates the mitogenicity of EGF and TGF-beta signaling in fetal mouse lung mesenchymal cells; to determine if different Shc 66 tyrosine phosphorylation sites are actived by EGF and TGF-beta signaling, and if different regulatory functions are associated with each site; and to determine if MAP kinase activation is feedback regulated through modulation of relative Shc isoform expression.

Publications

Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R. (2007). TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J.;26(17):3957-67.

Smith SM, Crowe DL, Lee MK. (2006). beta1 integrins modulate p66ShcA expression and EGF-induced MAP kinase activation in fetal lung cells. Biochem Biophys Res Comm. 342(4):909-918

Crowe DL, Lee MK. (2006). New role for nucleare hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines. Breast Cancer Res. 8(1):R1

Lee MK, Pryhuber GS, Schwarz MA, Smith SM, Pavlova Z, Sunday ME. (2005). Developmental regulation of p66Shc is altered by bronchopulmonary dysplasia in baboons and humans. Am J Respir Crit Care Med. 171:1384-94.

Schwarz MA, Wan ZS, Liu J, Lee MK. (2004). Epithelial-mesenchymal interactions are linked to neovascularization. Am J Respir Cell Molec Biol. 30(6):784-92.

Warburton D, Bellusci S, Del Moral PM, Kaartinen V, Lee M, Tefft D, Shi W. (2003). Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry. Respir Res. 4(1):5.

Tefft D, Lee M, Smith S, Crowe DL, Bellusci S, Warburton D. (2002). mSprouty2 inhibits FGF10-activated MAP kinase by differentially binding to upstream target proteins. Am J Physiol Lung Cell Mol Physiol 283(4):L700-L706

Crowe DL, Brown TN, Kim R, Smith SM, Lee MK (2000). A c-fos/Estrogen receptor fusion protein promotes cell cycle progression and proliferation of human cancer cell lines. Mol Cell Biol Res Commun 3(4):243-8

Warburton D, Lee MK (1999). Current concepts on lung development. Curr Opin Pediatr 11(3):188-92

Tefft JD, Lee M, Smith S, Leinwand M, Zhao J, Bringas P Jr, Crowe DL, Warburton D (1999). Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis. Curr Biol 9(4):219-22

Schwarz M, Lee M, Zhang F, Zhao J, Jin Y, Smith S, Bhuva J, Stern D, Warburton D, Starnes V (1999). EMAP II: a modulator of neovascularization in the developing lung. Am J Physiol 276(2 Pt 1):L365-75

Zhao J, Lee M, Smith S, Warburton D (1998). Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture. Dev Biol 194(2):182-95

Lee MK, Zhao J, Smith SM, Tefft JD, Bringas P, Hwang C, Warburton D (1998). The Shc 66 and 46 kD isoforms are differentially downregulated at parturition in the fetal mouse lung. Pediatr Res 44(6):850-9

Vo HP, Lee MK, Crowe DL (1998). alpha2beta1 integrin signaling via the mitogen activated protein kinase pathway modulates retinoic acid-dependent tumor cell invasion and transcriptional downregulation of matrix metalloproteinase 9 activity. Int J Oncol 13(6):1127-34

Zhao J, Bu D, Lee M, Slavkin HC, Hall FL, Warburton D (1996). Abrogation of transforming growth factor-beta type II receptor stimulates embryonic mouse lung branching morphogenesis in culture. Dev Biol 180(1):242-57

Zhao J, Frambach DA, Lee PP, Lee M, Lopez PF (1995). Delayed macular choriocapillary circulation in age-related macular degeneration. Int Ophthalmol 19(1):1-12

Gibson RL, Lee MK, Soderland C, Chi EY, Rubens CE (1993). Group B streptococci invade endothelial cells: type III capsular polysaccharide attenuates invasion. Infect Immun, 61,478-85

Warburton D, Lee MK, Berberich MA, Bernfield M (1993). Molecular embryology and the study of lung development. Am J Respir Cell Mol Biol, 9,5-9

Benca ML, Lee MK, Wang GR, Buckman S, et al (1995). The thrombin receptor is coupled to a GTP binding protein of the Ga_q family. FEBS Letters, 363:49-52

Abstracts

Lee MK, Slavkin HC, Warburton D. Transforming growth factor b isoforms interact differently with epidermal growth factor in fetal mouse lung mesenchymal cells. Am J Resp Crit Care Med. 1996:153(4), A241

Lee MK, Slavkin HC, Warburton D. EGF receptor tyrosine kinase activity but not tyrosine autophosphorylation is attenuated by TGF-b in fetal murine lung mesenchymal cells. Molec Biol Cell. 1995 6(suppl), 9a

Lee MK, Wuenschell C, Slavkin HC, Warburton D. Differential phosphorylation of 66 kd Shc by simultaneous exposure to epidermal growth factor and transforming growth factor-b. Am J Resp Crit Care Med. 1995:151(4), A299

Lee MK, Slavkin HC, Warburton D. Transforming Growth Factor b Crosstalk With Epidermal Growth Factor: Differential Roles In Fetal Mouse Lung Mesenchymal Cell Signalling. Am J Resp Crit Care Med. 1994:149(4), A709

Warburton D, Bu DS, Lee MK, Wuenschell CM, Hall FL, Slavkin HC. Role of transforming growth factor (TGF) beta signalling in early mouse embryo lung branching morphogenesis: crosstalk with EGF signalling pathways. Am J Resp Crit Care Med. 1994:149(4), A255

Lee MK, Chi EY, Hodson WA. Elastin deposition is increased by exposure to oxygen and indomethacin. Am J Resp Crit Care Med. 1992:145(4)

Last Updated: 03/31/08