CCMB Faculty

CSA A-207, HSC9062
(323)442-2573 Voice
(323)442-2981 Fax
yzhou@usc.edu

Yan Zhou

Ph.D.

Research Assistant Professor

Education Experience Honors & Awards Projects Publications

Education

INSTITUTION AND LOCATION	DEGREE	YEAR(s)	FIELD OF STUDY
Fudan University, Shanghai, China	B.Sc.	1990	Genetics and Genetic Engineering
Indiana University, Bloomington, IN		1995-97	Molecular, Cellular and Developmental Biology
University of Southern California, Los Angeles, CA	Ph.D.	2000	Craniofacial Biology

Research & Professional Experience

2003-present	Research Assistant Professor, Center of Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA
2001-2002	Postdoctoral Bioinformatics Scientist, Genentech Inc., San Francisco, CA
Aug.2000- -Dec.2000	Postdoctoral Research Associate, Center of Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA
1997-2000	Graduate Research Assistant, Center of Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA
1996-1997	Graduate Research Assistant, Indiana University, Bloomington, IN

1990-1995

Research Assistant, Shanghai Institute of Cell Biology, Chinese Academy of Sciences, Shanghai, China

Academic Honors and Awards

2002	Recognition Award, Genentech Inc.
2000	Academic Achievement Award, University of Southern California
1995-1996	Predoctoral Fellowship, Department of Biology, Indiana University, Bloomington, IN
1986-1990	Fudan University Scholarship, Department of genetics and Genetic Engineering, Fudan University, Shanghai, China

Research Projects

"Embryonic Stem Cells and Neural Crest Plasticity"

Principal Investigator: Yan Zhou , Ph.D.
Sponsor: National Institute of Dental and Craniofacial Research, NIH
Period: 06/05/07-05/31/09
The objective of this project is to regenerate tooth organ using dental mesenchyme derived from mouse embryonic stem cells.

"Human Embryonic Stem Cells and Neural Crest Osteogenesis"

Principal Investigator: Yan Zhou, Ph.D.
Sponsor: James H. Zumberge Faculty Research & Innovation Fund
Period: 07/01/07-06/30/09
The goal of this project is to investigate signaling effect of amelogenin on directing osteogenic differentiation of human embryonic stem cells.

Publications

Warotayanont R, Frenkel B, Snead ML, Zhou Y. (2009) Leucine-rich amelogenin peptide induces osteogenesis by activation of the Wnt pathway. Biochem Biophys Res Commun. 387(3):558-63.

Zhou Y, Snead ML. (2008). Derivation of cranial neural crest-like cells from human embryonic stem cells. Biochem Biophys Res Commun. 376(3):542-7.

Warotayanont R, Zhu D, Snead ML, Zhou Y. (2008). Leucine-rich amelogenin peptide induces osteogenesis in mouse embryonic stem cells. Biochem Biophys Res Commun. 367(1):1-6

Xu Y, Zhou YL, Gonzalez FJ, Snead ML. (2007) C/EBP-delta maintains amelogenin expression in the absence of C/EBP-alpha in vivo. J Biol Chem. 282(41):29882-9.

Xu Y, Zhou YL, Erickson RL, Macdougald OA, Snead ML. (2007). Physical dissection of the CCAAT/enhancer-binding protein alpha in regulating the mouse amelogenin gene. Biochem Biophys Res Commun. 354(1):56-61

Bartlett JD, Ganss B, Goldberg M, Moradian-Oldak J, Paine ML, Snead ML, Wen X, White SN, Zhou YL. (2006). Protein-protein interactions of the developing enamel matrix. Curr Top Dev Biol. 74:57-115.

Xu Y, Zhou YL, Ann DK, MacDougald OA, Shum L, Snead ML. (2006). Transcription factor sumoylation and factor YY1 serve to modulate mouse amelogenin gene expression. Eur J Oral Sci. 114 Suppl 1:169-77; discussion 201-2, 381.

Xu Y, Zhou YL, Luo W, Zhu QS, Levy D, Macdougald OA, Snead ML. (2006). NF-Y and CCAAT/enhancer-binding protein alpha synergistically activate the mouse amelogenin gene. J Biol Chem. 281(23):16090-8

Wen X, Lei YP, Zhou YL, Okamoto CT, Snead ML, Paine ML. (2005). Structural organization and cellular localization of tuftelin-interacting protein 11 (TFIP11). Cell Mol Life Sci. 62(9):1038-46.

Zhang Y, Eberhard DA, Frantz GD, Dowd P, Wu TD, Zhou Y, Watanabe C, Luoh SM, Polakis P, Hillan KJ, Wood WI, Zhang Z. (2004). GEPIS--quantitative gene expression profiling in normal and cancer tissues. Bioinformatic. 20(15):2390-8.

Zhou Y, Luoh SM, Zhang Y, Watanabe C, Wu TD, Ostland M, Wood WI, Zhang Z. (2003). Genome-wide Identification of Chromosomal Regions of Increased Tumor Expression by Transcriptome Analysis. Cancer Res. 63: 5781-5784

Zhou YL, Snead ML. (2000). Identification of CCAAT/enhancer-binding protein alpha as a transactivator of the mouse amelogenin gene. J Biol Chem;275(16):12273-80

Zhou YL, Lei Y, Snead ML (2000). Functional antagonism between Msx2 and CCAAT/enhancer-binding protein alpha in regulating the mouse amelogenin gene expression is mediated by protein-protein interaction. J Biol Chem 275:29066-75

Wei Y, Ni ZM, Zhou Y, Wu L, Shi LJ. (1994). The study of metaphasic chromosome pellicle. Acta Biologiae Experimentatis Sinica;27(4):505-13

Ni ZM, Yi N, Zhou Y, Shi LJ. (1994). The characteristics of the spindle fiber attachment (SFA) enriched fraction from mouse nuclei. Acta Biologiae Experimentatis Sinica. 26: 297-305

Last Updated: 10/07/09