CCMB Staff

CSA 115, HSC 9062
(323)442-2245 Voice
(323)442-2981 Fax
junichii@usc.edu

Junichi Iwata

D.D.S., Ph.D.

Postdoctoral Research Associate

Education Experience Publications

Education

INSTITUTION AND LOCATION	DEGREE	YEAR(s)	FIELD OF STUDY
Kyushu University, Japan	Ph.D.	2004	Oral Surgery and Pharmacology
Kyushu University, Japan	D.D.S.	2000	Dentistry

Research & Professional Experience

2007-present	Postdoctoral Research Associate, Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, CA
2004-2007	Assistant Professor in Department of Biochemistry, School of Medicine, Juntendo University
2004-2007	Research fellow, Center Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science
4/2004 -9/2004	Postdoctoral research fellow in Department of Pharmacology, Graduate School of Dental Science, Kyushu University, Japan

Publications

Komatsu M, Waguri S, Koike M, Sou Y, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, and Tanaka K. (2007) Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice. Cell, 131, 1149-1163

Kawakubo T, Okamoto K, Iwata J, Shin M, Okamoto Y, Yasukochi A, Nakayama K, Kadowaki T, Tsukuba T, and Yamamoto K. (2007) Cathepsin E Prevents Tumor Growth and Metastasis by Catalyzing the Proteolytic Release of Soluble TRAIL from Tumor Cell Surface. Cancer Research. 67(22):10869-78

Shin M, Kadowaki T, Iwata J, Kawakubo T, Yamaguchi N, Takii R, Tsukuba T, and Yamamoto K. (2007) Association of Cathepsin E with Tumor Growth Arrest through Angiogenesis Inhibition and Enhanced Immune Responses. Biol. Chem. 388(11):1173-81

Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr, Iwata J , Kominami E, Chait BT, Tanaka K, and Yue Z. (2007) Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A. Sep 4;104(36):14489-94.

Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, and Tanaka K. (2006). Loss of autophagy in the central nervous system causes neurodegeneration. Nature, 441 (7095), 880-4.

Iwata J, Ezaki J, Komatsu M, Yokota S, Ueno T, Tanida I, Chiba T, Tanaka K, and Kominami E. (2006). Excess peroxisomes are degraded by autophagic machinery in mammals. J. Biol. Chem. 281, 4035-41.

Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, and Chiba T. (2005). Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell Biol. 169, 425-434.

Iwata J, Kawakubo T, and Yamamoto K. (2004). Angiostatin, Connective Tissue, 36,165-169.

Iwata J, and Yamamoto K. (2004). Inhibition of angiogenesis, tumor growth, and metastasis by cathepsin E. Jikken Igaku Zokan. 22 (2) 213-219.

Last Updated: 12/14/07