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Research
& Professional Experience
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2008-present |
Research Associate, Center for Craniofacial Molecular
Biology, School of Dentistry, University of Southern California, Los
Angeles, CA |
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2004-2007 |
Postdoctoral Research Associate, Center for Craniofacial Molecular
Biology, School of Dentistry, University of Southern California, Los
Angeles, CA |
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2001-2004 |
Research
Associate, Department of Oral & Maxillofacial Surgery,
Charles R Drew University of Medicine and Science. |
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2000-2001 |
Postdoctoral
Research Fellow, Department of Oral Biology and Medicine, School of
Dentistry, UCLA |
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1997-2000 |
Research
Assistant, Department of Biochemistry & Molecular Biology,
West China University of Medical Sciences, Chengdu, China. |
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1994-1997 |
Research
Assistant, Institute of Medical Biochemistry of Guangdong Province,
Zhanjiang, Guangdong, China. |
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1987-1994 |
Laboratory
Instructor, Teaching Assistant, Molecular Biology and Biochemistry, Leshan
Health School of Sichuan Province, China |
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Publications
Zhang Q, Tang X,
Zhang ZF, Velikina R, Shi S, Le AD. (2007) Nicotine
induces hypoxia-inducible factor-1alpha expression in human lung cancer cells
via nicotinic acetylcholine receptor-mediated signaling pathways. Clin
Cancer Res. 13(16):4686-94.
Tang X, Zhang Q,
Nishitani J, Brown J, Shi S, Le AD. (2007). Overexpression
of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1
alpha protein accumulation and vascular endothelial growth factor expression in
human cervical carcinoma cells. Clin Cancer Res. 13(9):2568-76.
Zhang Q, Kelly AP, Wang L, French SW, Tang X,
Duong HS, Messadi DV, Le AD. (2006). Green
Tea Extract and (-)-Epigallocatechin-3-Gallate Inhibit Mast Cell-Stimulated Type
I Collagen Expression in Keloid Fibroblasts via Blocking PI-3K/Akt Signaling
Pathways. J Invest Dermatol. 126(12):2607-13
Zhang Q, Tang X,
Lu Q, Zhang Z, Rao J, Le AD. (2006). Green
tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and
serum-induced HIF-1alpha protein accumulation and VEGF expression in human
cervical carcinoma and hepatoma cells. Mol Cancer Ther. 5(5):1227-38.
Duong HS, Zhang QZ,
Le AD, Kelly AP, Kamdar R, Messadi DV. (2006). Elevated
prolidase activity in keloids: correlation with type I collagen turnover. Br
J Dermatol. 154(5):820-8.
Zhang Q, Oh CK,
Messadi DV, Duong HS, Kelly AP, Soo C, Wang L, Le AD. (2006). Hypoxia-induced
HIF-1 alpha accumulation is augmented in a co-culture of keloid fibroblasts and
human mast cells: involvement of ERK1/2 and PI-3K/Akt. Exp Cell Res.
312(2):145-55.
Duong HS, Le AD,
Zhang Q, Messadi DV. (2005). A
novel 3-dimensional culture system as an in vitro model for studying oral cancer
cell invasion. Int J Exp Pathol. 86(6):365-74.
Zhang Q, Tang X, Lu QY,
Zhang ZF, Brown J, Le AD. (2005). Resveratrol
inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and
VEGF expression in human tongue squamous cell carcinoma and hepatoma cells. Mol
Cancer Ther. 4(10):1465-74.
Chau
CH, Clavijo CA, Deng HT, Zhang Q, Kim KJ, Qiu Y, Le AD, Ann DK. (2005). Etk/Bmx
mediates the expression of stress-induced adaptive genes, VEGF, PAI-1, and iNOS
via multiple signaling cascades in different cell systems. Am J Physiol
Cell Physiol. 289(2):C444-54
Zhang
Q, Zhang ZF, Rao JY, Sato JD, Brown J, Messadi DV, Le AD. (2004). Treatment
with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced
apoptosis in human tongue squamous cell carcinomas. Int J Cancer.
111(6):849-57
Zhou
JJ, Chen ML, Zhang QZ, Hu JK, Wang WL. (2004). Co-expression of
cholecystokin-B/gastrin receptor and gastrin
gene in human gastric tissues and gastric cancer cell line.
World J Gastroenterology, 10(6): 791-794
Zhou
JJ, Hu JK, Chen Z, Wang WL, Zhang QZ, Chen M. (2004). Human gastric tissues
coexpress two different splicing cholecystokinin-B/gastrin receptors.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 21(3): 440-443
Messadi
DV, Duong HS, Zhang Q, Kelly AP, Tuan TL and Le AD. (2004). Activation
of NFKappaB signal pathways in keloid fibroblasts. Arch. Derm. Research,
296(3):125-33
Mohamed
KM, Le A, Duong H, Wu Y, Zhang Q, Messadi DV. (2004). Correlation
between VEGF and HIF-1alpha expression in human oral squamous cell carcinoma.
Exp Mol Pathol. 76(2):143-52
Wu
Y, Zhang Q, Ann DK, Akhondzadeh A, Duong HS, Messadi DV, Le AD. (2004). Increased
vascular endothelial growth factor may account for elevated level of plasminogen
activator inhibitor-1 via activating ERK1/2 in keloid fibroblasts. Am J
Physiol Cell Physiol. 286(4):C905-12
Zhang
Q, Wu Y, Chau CH, Ann DK, Bertolami CN, Le AD. (2004). Crosstalk
of hypoxia-mediated signaling pathways in upregulating plasminogen activator
inhibitor-1 expression in keloid fibroblasts. J Cell Physiol.,
199:89-97.
Le
AD, Zhang Q, Wu Y, Messadi DV, Akhondzadeh A, Nguyen AL, Aghaloo TL, Kelly AP,
Bertolami CN. (2004). Elevated
vascular endothelial growth factor in keloids: relevance to tissue fibrosis.
Cells Tissues Organs, 176(1-3): 87-94.
Zhang
Q, Wu Y, Ann DK, Messadi DV, Tuan TL, Kelly AP, Bertolami CN, Le AD. (2003).
Mechanisms
of hypoxic regulation of plasminogen activator inhibitor-1 gene expression in
keloid fibroblasts. J Invest Dermatol 121:1005-1012.
Zhang
QZ, Chen ML, Li RH.
(2003). Effects of hCG on the in vitro proliferation of human gastric
adenocarcinoma cell line (SGC-7901 cells).
Sichuan Da Xue Xue bao Yi Xue Ban, 34(4): 678-679.
Zhang
QZ, Li RH, Chen ML, Wu ZF. (2002). Effects of human
chorionic gonadotropin on intracellular signal transduction in human
gastroadenocarcinma SGC-7901 cells. Chin J Digest Diseases, 22: 470-473.
Zhang
QZ, Chen ML. (2000).
Effects of hCG on the cAMP levels in human
gastric cancer cells. J
West China University of Med Sci; 31(3): 312-314.
Zhang
QZ, Zhou KY, Cai KR, Ling GX. (1998). Changes of
Oncogen Expressions in Nasopharyngeal Carcinoma Cells During Apoptosis. Chin
J
Histochem Cytochem, 7(2): 168-172
Zhang
QZ, Zhou KY, Ling GX. (1997).
Apoptosis in Human nasopharyngeal Carcinoma Cell Lines Induced by DNA
Topo I Inhibitor. Chin J Otolaryngol, 32 (6): 332-3352.
Zhang
QZ, Zhou KY, Ling GX. (1997). Apoptosis of Leukemia Cells Induced by
adenosine. Chin J
Hemotol, 18(5):266
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