CSA113, HSC 9062 (323)442-3404 Voice (323)442-2981 Fax qunzhouz@usc.edu

Qunzhou Zhang

Ph.D.

Research Associate

Education

Research & Professional Experience

Academic Honors and Awards

Research Project

"Role of CD133+ Cancer Stem Cells in Head and Neck Cancer"

• Principal Investigator: Qunzhou Zhang, Ph.D.

• Agency: Oral and Maxillofacial Surgery Foundation (OMSF)

• Period: 03/01/2008-02/28/2009

• The major goal of this project is to identify a small subpopulation of CD133+ cancer stem cells from human oral squamous cell carcinomas (OSCCs) and explore their role in tumorigenesis and chemoresistance in oral cancer.

Publications

Zhang Q, Shi S, Liu Y, Uyanne J, Shi Y, Shi S, Le AD.  (2009) Mesenchymal Stem Cells Derived from Human Gingiva Are Capable of Immunomodulatory Functions and Ameliorate Inflammation-Related Tissue Destruction in Experimental Colitis. J Immunol. In press

Zhang Q, Yamaza T, Kelly AP, Shi S, Wang S, Brown J, Wang L, French SW, Shi S, Le AD. (2009) Tumor-Like Stem Cells Derived from Human Keloid Are Governed by the Inflammatory Niche Driven by IL-17/IL-6 Axis. PLoS One. 4(11):e7798.

Zhang Q, Shi S, Yen Y, Brown J, Ta JQ, Le AD. (2009)  A subpopulation of CD133(+) cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy. Cancer Lett. In Press. 

Tang X, Zhang Q, Shi S, Yen Y, Li X, Zhang Y, Zhou K, Le AD. (2009) Bisphosphonates suppress insulin-like growth factor 1-induced angiogenesis via the HIF-1alpha/VEGF signaling pathways in human breast cancer cells.  Int J Cancer.  126(1):90-103

Zhang Q, Tang X, Zhang ZF, Velikina R, Shi S, Le AD. (2007) Nicotine induces hypoxia-inducible factor-1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways. Clin Cancer Res. 13(16):4686-94.

Tang X, Zhang Q, Nishitani J, Brown J, Shi S, Le AD. (2007).  Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells. Clin Cancer Res. 13(9):2568-76.

Zhang Q, Kelly AP, Wang L, French SW, Tang X, Duong HS, Messadi DV, Le AD. (2006).  Green Tea Extract and (-)-Epigallocatechin-3-Gallate Inhibit Mast Cell-Stimulated Type I Collagen Expression in Keloid Fibroblasts via Blocking PI-3K/Akt Signaling Pathways. J Invest Dermatol. 126(12):2607-13

Zhang Q, Tang X, Lu Q, Zhang Z, Rao J, Le AD. (2006).  Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1alpha protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells. Mol Cancer Ther. 5(5):1227-38. 

Duong HS, Zhang QZ, Le AD, Kelly AP, Kamdar R, Messadi DV. (2006). Elevated prolidase activity in keloids: correlation with type I collagen turnover. Br J Dermatol. 154(5):820-8.

Zhang Q, Oh CK, Messadi DV, Duong HS, Kelly AP, Soo C, Wang L, Le AD. (2006). Hypoxia-induced HIF-1 alpha accumulation is augmented in a co-culture of keloid fibroblasts and human mast cells: involvement of ERK1/2 and PI-3K/Akt. Exp Cell Res. 312(2):145-55.

Duong HS, Le AD, Zhang Q, Messadi DV. (2005).  A novel 3-dimensional culture system as an in vitro model for studying oral cancer cell invasion. Int J Exp Pathol. 86(6):365-74.

Zhang Q, Tang X, Lu QY, Zhang ZF, Brown J, Le AD. (2005). Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells. Mol Cancer Ther. 4(10):1465-74.

Chau CH, Clavijo CA, Deng HT, Zhang Q, Kim KJ, Qiu Y, Le AD, Ann DK. (2005). Etk/Bmx mediates the expression of stress-induced adaptive genes, VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems. Am J Physiol Cell Physiol.  289(2):C444-54

Zhang Q, Zhang ZF, Rao JY, Sato JD, Brown J, Messadi DV, Le AD. (2004). Treatment with siRNA and antisense oligonucleotides targeted to HIF-1alpha induced apoptosis in human tongue squamous cell carcinomas. Int J Cancer. 111(6):849-57

Zhou JJ, Chen ML, Zhang QZ, Hu JK, Wang WL.  (2004). Co-expression of cholecystokin-B/gastrin receptor and gastrin gene in human gastric tissues and gastric cancer cell line.  World J Gastroenterology, 10(6): 791-794

Zhou JJ, Hu JK, Chen Z, Wang WL, Zhang QZ, Chen M. (2004). Human gastric tissues coexpress two different splicing cholecystokinin-B/gastrin receptors.  Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 21(3): 440-443

Messadi DV, Duong HS, Zhang Q, Kelly AP, Tuan TL and Le AD. (2004).  Activation of NFKappaB signal pathways in keloid fibroblasts. Arch. Derm. Research, 296(3):125-33

Mohamed KM, Le A, Duong H, Wu Y, Zhang Q, Messadi DV. (2004). Correlation between VEGF and HIF-1alpha expression in human oral squamous cell carcinoma.  Exp Mol Pathol. 76(2):143-52

Wu Y, Zhang Q, Ann DK, Akhondzadeh A, Duong HS, Messadi DV, Le AD. (2004). Increased vascular endothelial growth factor may account for elevated level of plasminogen activator inhibitor-1 via activating ERK1/2 in keloid fibroblasts. Am J Physiol Cell Physiol. 286(4):C905-12

Zhang Q, Wu Y, Chau CH, Ann DK, Bertolami CN, Le AD.  (2004). Crosstalk of hypoxia-mediated signaling pathways in upregulating plasminogen activator inhibitor-1 expression in keloid fibroblasts.  J Cell Physiol., 199:89-97.

Le AD, Zhang Q, Wu Y, Messadi DV, Akhondzadeh A, Nguyen AL, Aghaloo TL, Kelly AP, Bertolami CN. (2004). Elevated vascular endothelial growth factor in keloids: relevance to tissue fibrosis. Cells Tissues Organs, 176(1-3): 87-94.

Zhang Q, Wu Y, Ann DK, Messadi DV, Tuan TL, Kelly AP, Bertolami CN, Le AD. (2003).  Mechanisms of hypoxic regulation of plasminogen activator inhibitor-1 gene expression in keloid fibroblasts.  J Invest Dermatol 121:1005-1012.

Zhang QZ, Chen ML, Li RH.  (2003). Effects of hCG on the in vitro proliferation of human gastric adenocarcinoma cell line (SGC-7901 cells).  Sichuan Da Xue Xue bao Yi Xue Ban, 34(4): 678-679.

Zhang QZ, Li RH, Chen ML, Wu ZF. (2002). Effects of human   chorionic gonadotropin on intracellular signal transduction in human gastroadenocarcinma SGC-7901 cells. Chin J Digest Diseases, 22: 470-473.

Zhang QZ, Chen ML. (2000).  Effects of hCG on the cAMP levels in human   gastric cancer cells. J  West China University of Med Sci; 31(3): 312-314. 

Zhang QZ, Zhou KY, Cai KR, Ling GX. (1998). Changes of  Oncogen Expressions in Nasopharyngeal Carcinoma Cells During Apoptosis. Chin J  Histochem Cytochem, 7(2): 168-172

Zhang QZ, Zhou KY, Ling GX. (1997).  Apoptosis in Human nasopharyngeal Carcinoma Cell Lines Induced by DNA Topo I Inhibitor. Chin J Otolaryngol, 32 (6): 332-3352. 

Zhang QZ, Zhou KY, Ling GX. (1997). Apoptosis of Leukemia Cells Induced by adenosine. Chin J  Hemotol, 18(5):266 

Last Updated: 11/13/09

HOME | Overview | Founder | Director | Faculty | Administration Staff | Laboratory Staff | Publications
 Research Grants | CBY | T32 | Seminar Schedule | Resources & Facilities | Web Resources