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LABORATORY FOR PHARMACODYNAMIC RESEARCH
CURRENT STUDIES
| Project Title |
Bioavailability and Intracellular Pharmacokinetics
of Azithromycin in Adult Patients with Cystic Fibrosis |
| Investigators |
Paul Beringer, Pharm.D.
Thao Nguyen, Pharm.D., Stan Louie, Pharm.D., Ph.D., Mark Gill, Pharm.D.,
and Bertrand Shapiro, M.D. |
| Purpose |
To compare the systemic bioavailability and intracellular concentrations
of azithromycin in adult patients with cystic fibrosis versus healthy volunteers |
| Duration |
The research will take place within the General Clinical Research Center
(GCRC) at LAC+USC Medical Center. |
| Number of Participants |
24 |
| Eligibility |
Patients must be 18 years of age or older |
| Sponsor |
Webb-Berger Cystic Fibrosis Research Award |
| Project Title |
Pharmacodynamics of continuous infusion cefepime
in patients with cystic fibrosis |
| Investigators |
Thao Nguyen, Pharm.D., Paul Beringer,
Pharm.D.,
Stan Louie, Pharm.D., Mark Gill, Pharm.D., Megan Montgomery, Pharm.D., and
Bertrand Shapiro, M.D. |
| Purpose |
To determine the safety and effectiveness of a new administration method
for the antibiotic cefepime |
| Duration |
The research will take place during a patient's hospitalization for
an acute exacerbation. |
| Number of Participants |
24 |
| Eligibility |
Patients must be 18 years of age or older, and be colonized with
P. aeruginosa |
| Sponsor |
Dura Pharmaceuticals |
| Project Title |
Bactericidal activity of Ampicillin-sulbactam,
Gatifloxacin, and their combination against Acinetobacter baumannii
. |
| Investigators |
Paul Beringer, Pharm.D., Mark Gill, Pharm.D., Stan Louie, Pharm.D.,
Ph.D. |
| Purpose |
To determine the synergistic potential of gatifloxacin when given in
combination with ampicillin-sulbactam against clinical isolates of Acinetobacter
baumannii. |
| Duration |
The research will take place within the General Clinical Research Center
(GCRC) at LAC+USC Medical Center. |
| Number of Partipants |
12 |
| Eligibility |
Adult healthy volunteers |
| Sponsor |
Bristol-Myers Squibb |
| Project Title |
Paradoxical effects of Ritonavir
on P-glycoprotein and Cytochrome P450 3A4 and 2C8 expression: Regulation
by Orphan Nuclear Factor, Steroid Xenobiotics Receptor (SXR). |
| Investigators |
Stan Louie, Pharm.D
, Wei-Chiang Shen, Ph.D., Tim Synold, Pharm.D., Paul Beringer, Pharm.D.,
and Mark Gill, Pharm.D. |
| Purpose |
(1)Establish whether steroid xenobiotic receptor (SXR) is
both constitutively and inducibly expressed and activated and (2) Establish
whether there is a threshold concentration for protease inhibitor (PI) regulating
the expression of cytochrome p450 3A4 (CYP3A4), and p-glycoprotein (Pgp)
through SXR activation. |
| Sponsor |
ASHP Foundation Basic Science-Applied Therapeutics Research
Grant |
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