Education:
BS 1966 Sciences - Lycee Lalande, Bourg-en-Bress, France
Eng 1971 Chemistry - Ecole Polytechnique, Paris, France
PhD 1977 Biochemistry - University of Paris VII, France
Postdoctoral Research Fellowship:
1978-1980 University of California, Irvine
Started at USC: 1989
Research Topics: Learning & Memory
Research Description
Mechanisms implicated in long-term synaptic potentiation and depression in hippocampus and other brain regions. My laboratory has been investigating for several years the molecular and cellular mechanisms underlying LTP and LTD phenomena in adult rats and rabbits. We have been using a combination of electrophysiological, neurochemical and neuroanatomical techniques to study the roles of various biochemical processes in regulating short-term as well as long-term changes in synaptic efficacy.
Regulation of glutamate receptors. My laboratory has been studying post-translational mechanisms regulating the properties of the AMPA and NMDA receptors. In particular, we are investigating the mechanisms involved in the maturation, processing, insertion and internalisation of the receptors. We are also evaluating the role of calpain-mediated truncation of the C-terminal domains of certain subunits of the receptors in receptor function and regulation.
Role of oxygen free radicals in central nervous system. As a result of my association with Eukarion, Inc., a small start-up pharmaceutical company in Bedford, MA., my laboratory has been investigating the roles of oxygen free radicals in neurodegenerative phenomena. In particular, we have tested the protective effects of a new class of synthetic catalytic scavengers of reactive oxygen intermediates on neuronal damage elicited by excitotoxins, neurotoxins, and beta-amyloid peptides.
Mechanisms underlying selective neuronal degeneration. In collaboration with Dr. Steve Schreiber, we have been interested in studying molecular and cellular mechanisms underlying selective neuronal degeneration resulting from neuronal insults or injury. In particular, we have been identifying a number of genes activated as a result of intense neuronal activity in neuronal populations selectively damaged under these conditions. Using a combination of pharmacology and selective suppression of the expression of these genes, we are evaluating their contribution to neuronal death resulting from programmed cell death or apoptosis.
My laboratory is also involved in several program projects:
. Human Brain Project: under this program project, my laboratory is developing new tools to incorporate neurochemical/neuroanatomical data into a large Neuroscience Database. In particular, we have developed tools to analyze autoradiographic as well as immunohistochenistry images in reference to a 3D-rat brain Atlas.
. Estrogen and Alzheimer's disease: under this program project, my laboratory is investigating the mechanisms underlying the potential neuroprotective of estrogen and related steroids in Alzheimer's disease.
. Neural tissue/silicon chips interfaces: in collaboration with Dr. Ted Berger, my laboratory is evaluating new technologies to record/stimulate neuronal activity of large ensemble of neurons.
Selected Publications
Clausen A, Doctrow S, Baudry M. - Prevention of cognitive deficits and brain oxidative stress with superoxide dismutase/catalase mimetics in aged mice. - Neurobiol Aging [ 2008 ] Jun 18; . PubMed
Ferrand E, Jabre P, Vincent-Genod C, Aubry R, Badet M, Badia P, Cariou A, Ellien F, Gounant V, Gil R, Jaber S, Jay S, Paillaud E, Poulain P, Regnier B, Reignier J, Socie G, Tardy B, Lemaire F, Brun-Buisson C, Marty J. - Circumstances of death in hospitalized patients and nurses' perceptions: French multicenter Mort-a-l'H??pital survey. - Arch Intern Med [ 2008 ] Apr 28;168(8):867-75 . PubMed
Foy MR, Baudry M, Foy JG, Thompson RF. - 17beta-estradiol modifies stress-induced and age-related changes in hippocampal synaptic plasticity. - Behav Neurosci [ 2008 ] Apr;122(2):301-9 . PubMed
Brinton RD, Thompson RF, Foy MR, Baudry M, Wang J, Finch CE, Morgan TE, Pike CJ, Mack WJ, Stanczyk FZ, Nilsen J. - Progesterone receptors: form and function in brain. - Front Neuroendocrinol [ 2008 ] May;29(2):313-39 . PubMed
Quach TT, Massicotte G, Belin MF, Honnorat J, Glasper ER, Devries AC, Jakeman LB, Baudry M, Duchemin AM, Kolattukudy PE. - CRMP3 is required for hippocampal CA1 dendritic organization and plasticity. - FASEB J [ 2008 ] Feb;22(2):401-9 . PubMed
Gholmieh GI, Courellis SH, Fluster D, Chen LS, Marmarelis VZ, Baudry M, Berger TW. - Improving bioassay sensitivity for neurotoxins detection using volterra based third order nonlinear analysis. - Conf Proc IEEE Eng Med Biol Soc [ 2007 ] 2007:2261-4 . PubMed
Xu W, Zhou M, Baudry M. - Neuroprotection by Cell Permeable TAT-mGluR1 Peptide in Ischemia: Synergy Between Carrier and Cargo Sequences. - Neuroscientist [ 2007 ] Nov 13; . PubMed
Zhou M, Dominguez R, Baudry M. - Superoxide dismutase/catalase mimetics but not MAP kinase inhibitors are neuroprotective against oxygen/glucose deprivation-induced neuronal death in hippocampus. - J Neurochem [ 2007 ] Dec;103(6):2212-23 . PubMed
Menard C, Chartier E, Patenaude C, Robinson P, Cyr M, Baudry M, Massicotte G. - Calcium-independent phospholipase A(2) influences AMPA-mediated toxicity of hippocampal slices by regulating the GluR1 subunit in synaptic membranes. - Hippocampus [ 2007 ] 17(11):1109-20 . PubMed
Xu W, Wong TP, Chery N, Gaertner T, Wang YT, Baudry M. - Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity. - Neuron [ 2007 ] Feb 1;53(3):399-412 . PubMed
