Education:
BS 1985 Chemistry- Manchester Polytechnic, U.K.
PhD 1989 Physical Organic Chemistry- Liverpool University
Postdoctoral Research Fellowship:
1989-1982 Oxford University,United Kingdom
Started at USC: 1992
Research Topics: DNA & RNA, Computational Biology, Drug Design, Delivery, Structural Biology
Research Description
My laboratory uses computer simulation and gel electrophoresis to study the molecular interactions and reactions between small molecules and DNA. We use these techniques to study the polyamine-DNA interaction, and to investigate mechanisms of DNA alkylation by anti-tumor agents.
We also use simulation approaches to study a number of ligand interactions with proteins. We have active research in the areas of peptide-MHC interactions, in the computer-aided design of TGF-beta Inhibitors.
We are also developing new computational methods to generate DNA molecules in any conformation and to simulate DNA conformational transitions. In this context, we have a particular interest in conformations adopted by trinucleotide repeat DNA sequences.
Selected Publications
Li K, Xu L, Kulkarni AA, Perkins DI, Haworth IS, Davies DL. - Ethanol Inhibits Functional Activity of the Human Intestinal Dipeptide Transporter hPepT1 Expressed in Xenopus Oocytes. - Alcohol Clin Exp Res [ 2008 ] Mar 11; . PubMed
Dowd CL, Sutch BT, Haworth IS, Eritja R, Marquez VE, Yang AS. - Incorporation of zebularine from its 2'-deoxyribonucleoside triphosphate derivative and activity as a template-coding nucleobase. - Nucleosides Nucleotides Nucleic Acids [ 2008 ] Feb;27(2):131-45 . PubMed
Qin PZ, Haworth IS, Cai Q, Kusnetzow AK, Grant GP, Price EA, Sowa GZ, Popova A, Herreros B, He H. - Measuring nanometer distances in nucleic acids using a sequence-independent nitroxide probe. - Nat Protoc [ 2007 ] 2(10):2354-65 . PubMed
Price EA, Sutch BT, Cai Q, Qin PZ, Haworth IS. - Computation of nitroxide-nitroxide distances in spin-labeled DNA duplexes. - Biopolymers [ 2007 ] Sep;87(1):40-50 . PubMed
Cai Q, Kusnetzow AK, Hideg K, Price EA, Haworth IS, Qin PZ. - Nanometer distance measurements in RNA using site-directed spin labeling. - Biophys J [ 2007 ] Sep 15;93(6):2110-7 . PubMed
Schiewe AJ, Haworth IS. - Structure-based prediction of MHC-peptide association: algorithm comparison and application to cancer vaccine design. - J Mol Graph Model [ 2007 ] Oct;26(3):667-75 . PubMed
Bui HH, Schiewe AJ, Haworth IS. - WATGEN: an algorithm for modeling water networks at protein-protein interfaces. - J Comput Chem [ 2007 ] Nov 15;28(14):2241-51 . PubMed
Links JL, Kulkarni AA, Davies DL, Lee VH, Haworth IS. - Cysteine scanning of transmembrane domain three of the human dipeptide transporter: implications for substrate transport. - J Drug Target [ 2007 ] Apr;15(3):218-25 . PubMed
Kulkarni AA, Davies DL, Links JS, Patel LN, Lee VH, Haworth IS. - A charge pair interaction between Arg282 in transmembrane segment 7 and Asp341 in transmembrane segment 8 of hPepT1. - Pharm Res [ 2007 ] Jan;24(1):66-72 . PubMed
Haworth IS. - Computational drug delivery. - Adv Drug Deliv Rev [ 2006 ] Nov 30;58(12-13):1271-3 . PubMed
