| Send E-mail to: dhinton@usc.edu | |
| Telephone: 323-442-6617 | Fax: 323-442-6688 |
| Office: DOH 213 | Mail Code: 9092 HSC |
Education:
MD 1978 Medicine - University of Toronto, Ontario, Canada
FRCP(C) 1983 Neuropathology- University of Toronto, Ontario, Canada
Postdoctoral Research Fellowship:
1978-1979 University of Toronto, Ontario, Canada
Started at USC: 1988
Research Topics: Aging, Gene Therapy, Vision Research, Cellular Neurobiology
Research Description
Dr. Hinton's research focuses on the response of the outer retina to injury and how this response can lead to blinding disorders such as proliferative vitreoretinopathy (PVR) and choroidal neovascularization (CNV). PVR occurs as a wound healing response to severe ocular trauma or retinal detachment while CNV occurs primarily as a blinding complication of age-related macular degeneration. He has established the central role of the retinal pigment epithelial (RPE) cell in these disorders and has demonstrated novel mechanisms for growth factor activation of these cells. He is investigating the pathologic consequences of this activation on RPE migration, proliferation and gene expression. In particular he is interested in how the activated RPE cell can alter the local retinal microenvironment to promote the development of intraocular proliferative membranes and neovascularization from the adjacent choroidal endothelium. Dr. Hinton has developed and validated several in vitro and in vivo models of PVR and CNV and has used these models to elucidate basic mechanisms of disease and to evaluate novel therapeutic approaches to the disorders. He is especially interested in therapeutic approaches involving manipulation of growth factor receptors, and their intracellular signaling pathways. Dr. Hinton is also interested in the pathophysiology of viral infection in the brain and its relationship to demyelination. He is particularly interested in the mechanisms involved in leukocyte infiltration into the brain in viral infection.
Selected Publications
Li J, Ni M, Lee B, Barron E, Hinton DR, Lee AS. - The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. - Cell Death Differ [ 2008 ] Jun 13; . PubMed
Lundberg P, Ramakrishna C, Brown J, Tyszka JM, Hamamura M, Hinton DR, Kovats S, Nalcioglu O, Weinberg K, Openshaw H, Cantin EM. - The Immune Response to Herpes Simplex Virus Type 1 Infection in Susceptible Mice is a Major Cause of CNS Pathology Resulting in Fatal Encephalitis. - J Virol [ 2008 ] May 14; . PubMed
He S, Chen Y, Khankan R, Barron E, Burton R, Zhu D, Ryan SJ, Oliver N, Hinton DR. - Connective Tissue Growth Factor as a Mediator of Intraocular Fibrosis. - Invest Ophthalmol Vis Sci [ 2008 ] Apr 30; . PubMed
Sreekumar PG, Zhou J, Sohn J, Spee C, Ryan SJ, Maurer BJ, Kannan R, Hinton DR. - N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice. - Invest Ophthalmol Vis Sci [ 2008 ] Mar;49(3):1210-20 . PubMed
He S, Yaung J, Kim YH, Barron E, Ryan SJ, Hinton DR. - Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells. - Graefes Arch Clin Exp Ophthalmol [ 2008 ] May;246(5):677-83 . PubMed
Yaung J, Kannan R, Wawrousek EF, Spee C, Sreekumar PG, Hinton DR. - Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. - Exp Eye Res [ 2008 ] Feb;86(2):355-65 . PubMed
Stohlman SA, Hinton DR, Parra B, Atkinson R, Bergmann CC. - CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus. - J Virol [ 2008 ] Mar;82(5):2130-9 . PubMed
Ireland DD, Stohlman SA, Hinton DR, Atkinson R, Bergmann CC. - Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells. - J Virol [ 2008 ] Jan;82(1):300-10 . PubMed
Colodetti L, Weiland JD, Colodetti S, Ray A, Seiler MJ, Hinton DR, Humayun MS. - Pathology of damaging electrical stimulation in the retina. - Exp Eye Res [ 2007 ] Jul;85(1):23-33 . PubMed
Yaung J, Jin M, Barron E, Spee C, Wawrousek EF, Kannan R, Hinton DR. - alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. - Mol Vis [ 2007 ] Apr 4;13:566-77 . PubMed
