Education:
BS 1965 Chemistry - Tunghai University, Taichung, Taiwan
PhD 1972 Bio-Organic Chemistry - Boston University, Boston, MA
Postdoctoral Research Fellowship:
1972-1973 Harvard Medical School, Boston, Massachusetts
Started at USC: 1987
Research Topics: Cancer Treatment, Membranes & Transport, Protein Chemistry/Enzymology, Drug Design, Delivery
Research Description
Proteins and peptides represent a new generation of therapeutic agents which appear to be more potent and specific, yet less toxic than the conventional drugs. Biotechnological companies have successfully produced large numbers of proteins and peptides, including interleukins and growth factors, that are potentially useful for the treatment of various human diseases. However, the application of these biotechnological products is, to a large extent, limited by the availability of practical routes of administration. In particular, the oral delivery of peptides and proteins, which is dubbed "the Holy Grail of drug delivery", is still considered by many pharmaceutical scientists as an impossible goal to achieve at the present time.
Selected Publications
Yuan L, Wang J, Shen WC. - Lipidization of human interferon-alpha: A new approach toward improving the delivery of protein drugs. - J Control Release [ 2008 ] Mar 26; . PubMed
Bahhady R, Kim KJ, Borok Z, Crandall ED, Shen WC. - Characterization of protein factor(s) in rat bronchoalveolar lavage fluid that enhance insulin transport via transcytosis across primary rat alveolar epithelial cell monolayers. - Eur J Pharm Biopharm [ 2008 ] Feb 6; . PubMed
Norouziyan F, Shen WC, Hamm-Alvarez SF. - Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells. - Am J Physiol Cell Physiol [ 2008 ] Jan;294(1):C7-21 . PubMed
Patel LN, Uchiyama T, Kim KJ, Borok Z, Crandall ED, Shen WC, Lee VH. - Molecular and functional expression of multidrug resistance-associated protein-1 in primary cultured rat alveolar epithelial cells. - J Pharm Sci [ 2008 ] Jun;97(6):2340-9 . PubMed
Lim CJ, Norouziyan F, Shen WC. - Accumulation of transferrin in Caco-2 cells: a possible mechanism of intestinal transferrin absorption. - J Control Release [ 2007 ] Oct 8;122(3):393-8 . PubMed
Bahhady R, Kim KJ, Borok Z, Crandall ED, Shen WC. - Enhancement of insulin transport across primary rat alveolar epithelial cell monolayers by endogenous cellular factor(s). - Pharm Res [ 2007 ] Sep;24(9):1713-9 . PubMed
Patel LN, Zaro JL, Shen WC. - Cell penetrating peptides: intracellular pathways and pharmaceutical perspectives. - Pharm Res [ 2007 ] Nov;24(11):1977-92 . PubMed
Bai Y, Shen WC. - Improving the oral efficacy of recombinant granulocyte colony-stimulating factor and transferrin fusion protein by spacer optimization. - Pharm Res [ 2006 ] Sep;23(9):2116-21 . PubMed
Shen LJ, Shen WC. - Drug evaluation: ADI-PEG-20--a PEGylated arginine deiminase for arginine-auxotrophic cancers. - Curr Opin Mol Ther [ 2006 ] Jun;8(3):240-8 . PubMed
Wang J, Hogenkamp DJ, Tran M, Li WY, Yoshimura RF, Johnstone TB, Shen WC, Gee KW. - Reversible lipidization for the oral delivery of leu-enkephalin. - J Drug Target [ 2006 ] Apr;14(3):127-36 . PubMed
