Jean C. Shih
Professor
Cell & Neurobiology, Molecular Pharmacology & Toxicology
Keck School of Medicine
School of Pharmacy
Research Topics
- Neurogenetics
- Bioinformatics
- Pharmacology
- Signal Transduction
Research Overview
My research objectives are to understand the roles of neurotransmitters on gene expression, signal transduction and ultimately behaviors. We are currently using DNA chips, proteomics and bioinformatic approaches to study the role of serotonin and dopamine in neuronal development, regulation of transcription factors in a series of monoamine oxidase (MAO) gene knock-out and transgenic mice, which exhibit different behaviors including anxiety, aggression and irregular heart-rate under stress. This information will be linked to human databases and help identify polymorphism and SNP in genes related to mental disorders such as bipolar depression, schizophrenia, Alzheimer's and Parkinson's diseases.. These studies will not only provide new knowledge on the molecular mechanisms of brain functions but also help us understand the molecular basis of mental disorders. The new information obtained will be useful for designing novel therapeutic agents and early diagnosis of these diseases.Contact Information
- Web Sites:
- School of Pharmacy
PIBBS (Programs in Biomedical and Biosciences
Jean C. Shih Lab - E-mail:
- jcshih@usc.edu
- Mailing Address:
- 9121 HSC
- Office Location:
- PSC 518
- Office Phone:
- (323) 442-1441
- Fax:
- (323) 224-7473
Education
- BS 1964 Biochemistry - National Taiwan University, Taiwan
- PhD 1968 Biochemistry - University of California, Riverside
- Postdoctoral Research Fellowship:
- 1968 - 1970 University of California, Los Angeles
Selected Publications
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Chang TY, Shih JC, Chen CC. (2008) P44.17: Prenatal 'real-time' ultrasound findings of epulis at 34 weeks- a case report. Ultrasound Obstet Gynecol. 32(3):462-463. -PubMed
Huang SY, Chueh HY, Shaw SW, Shih JC, Cheng PJ. (2008) Sonographic diagnosis of fetal malformations associated with mycophenolate mofetil exposure in utero. Am J Obstet Gynecol. 199(2):e6-8. -PubMed
Shyu MK, Lin MC, Liu CH, Fu YR, Shih JC, Lee CN, Chen HY, Huang J, Huang MC, Hsieh FJ. (2008) MUC1 Expression Is Increased During Human Placental Development and Suppresses Trophoblast-Like Cell Invasion In Vitro. Biol Reprod. 79(2):233-239. -PubMed
Bortolato M, Chen K, Shih JC. (2008) Monoamine oxidase inactivation: From pathophysiology to therapeutics. Adv Drug Deliv Rev. (In press). -PubMed
Scott AL, Bortolato M, Chen K, Shih JC. (2008) Novel monoamine oxidase A knock out mice with human-like spontaneous mutation. Neuroreport. 19(7):739-743. -PubMed
Guo G, Ou XM, Roettger M, Shih JC. (2008) The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity. Eur J Hum Genet. 16(5):626-634. -PubMed
Chen CP, Shih JC, Tzen CY, Chern SR, Lin CJ, Wang W. (2008) Prenatal visualization of cebocephaly with a prominent nose in a second-trimester fetus with alobar holoprosencephaly and trisomy 13. Taiwan J Obstet Gynecol. 47(1):95-97. -PubMed
Yang JH, Shih JC, Liu KL, Yang YS. (2007) Combined treatment with temporary intraoperative balloon occlusion of common iliac arteries and hysteroscopic endocervical resection with postoperative cervical balloon for intractable cervical pregnancy in an infertile woman. Fertil Steril. 88(5):1438.e11-3. -PubMed
Shyu MK, Lin MC, Shih JC, Lee CN, Huang J, Liao CH, Huang IF, Chen HY, Huang MC, Hsieh FJ. (2007) Mucin 15 is expressed in human placenta and suppresses invasion of trophoblast-like cells in vitro. Hum Reprod. 22(10):2723-2732. -PubMed
Shih JC. (2007) Monoamine oxidases: from tissue homogenates to transgenic mice. Neurochem Res. 32(10):1757-1761. -PubMed