Caleb E. Finch
ARCO-William F. Kieschnick Professor in the Neurobiology of Aging,
Leonard Davis School of Gerontology,
Professor of Molecular & Computational Biology, Neurobiology, and Neurological Sciences
Co-Director, USC Alzheimer Disease Research Center
Research Topics
- Brain
- Aging
- Inflammation
- Demography
- Evolution
- Estrogen
- Alzheimer
Research Overview
Finch's main interests are the genomic regulation of aging processes. He has authored three books: Longevity, Senescence, and the Genome (1990); Aging: A Natural History (1995, with R. Ricklefs); Chance, Development, and Aging (2000, with TBL Kirkwood); and The Biology of Human Longevity (2007). In 450 reports and reviews since 1966, Finch has lead several developments in the fields of the neuroendocrinology and pharmacology of normal aging and Alzheimer disease, and in the biodemography of aging.Contact Information
- Web Sites:
- Andrus Gerontology Center
Alzheimer's Disease Research Center - E-mail:
- cefinch@usc.edu
- Mailing Address:
- University of Southern California
3715 McClintock
Los Angeles, CA 90089-0191 - Office Location:
- GER 336
- Office Phone:
- (213) 740-1758
- Lab Location:
- GER 340
- Lab Phone:
- (213) 740-6243
- Fax:
- (213) 740-0853
Education
- B.S., Yale University, 1961.
- Ph.D., Rockefeller University, 1969.
Selected Publications
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Finch CE. (2008) Lipids and lifespans: Constants and contradictions. Exp Gerontol. (In press). -PubMed
Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G 3rd, Kenny PJ, Wahlestedt C. (2008) Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat Med. 2008 Jul;14(7):723-30. -PubMed
Brinton RD, Thompson RF, Foy MR, Baudry M, Wang J, Finch CE, Morgan TE, PikeCJ, Mack WJ, Stanczyk FZ, Nilsen J. (2008) Progesterone receptors: form and function in brain.Front Neuroendocrinol. 29:313-39. -PubMed
Drevenstedt GL, Crimmins EM, Vasunilashorn S, Finch CE. (2008) The rise and fall of excess male infant mortality. Proc Natl Acad Sci U S A. 105:5016-21. -PubMed
Pan F, Chiu CH, Pulapura S, Mehan MR, Nunez-Iglesias J, Zhang K, Kamath K, Waterman MS, Finch CE, Zhou XJ. (2007) Gene Aging Nexus: a web database and data mining platform for microarray data on aging. Nucleic Acids Res. 35(Database issue):D756-9. -PubMed
Morgan TE, Wong AM, Finch CE (2007) Anti-inflammatory mechanisms of dietary restriction in slowing aging processes. Interdiscip Top Gerontol. 35:83-97. -PubMed
Crimmins EM, Finch CE. (2006) Infection, inflammation, height, and longevity. Proc Natl Acad Sci U S A. 103:498-503. -PubMed
Patel NV, Gordon MN, Connor KE, Good RA, Engelman RW, Mason J, Morgan DG, Morgan TE, Finch CE. (2005) Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models.Neurobiol Aging. 26:995-1000 -PubMed
Finch CE. (2005) Developmental origins of aging in brain and blood vessels: an overview. Neurobiol Aging. 26:281-91 -PubMed
Rozovsky I, Wei M, Morgan TE, Finch CE (2005) Reversible age impairments in neurite outgrowth by manipulations of astrocytic GFAP. Neurobiol Aging. 26:705-15 -PubMed