University of Southern California

USC Neuroscience

Caleb E. Finch

ARCO-William F. Kieschnick Professor in the Neurobiology of Aging,
Leonard Davis School of Gerontology,
Professor of Molecular & Computational Biology, Neurobiology, and Neurological Sciences
Co-Director, USC Alzheimer Disease Research Center

Research Topics

  1. Brain
  2. Aging
  3. Inflammation
  4. Demography
  5. Evolution
  6. Estrogen
  7. Alzheimer

Research Overview

Finch's main interests are the genomic regulation of aging processes. He has authored three books: Longevity, Senescence, and the Genome (1990); Aging: A Natural History (1995, with R. Ricklefs); Chance, Development, and Aging (2000, with TBL Kirkwood); and The Biology of Human Longevity (2007). In 450 reports and reviews since 1966, Finch has lead several developments in the fields of the neuroendocrinology and pharmacology of normal aging and Alzheimer disease, and in the biodemography of aging. A new project explores the impact of air pollution derived from motor vehicles on brain development and aging, which we showed to include effects on glutamatergic neurons (Morgan et al 2011).

Contact Information

Web Sites:
Andrus Gerontology Center
Alzheimer's Disease Research Center
E-mail:
cefinch@usc.edu
Mailing Address:
University of Southern California
3715 McClintock
Los Angeles, CA 90089-0191
Office Location:
GER 336
Office Phone:
(213) 740-1758
Lab Location:
GER 340
Lab Phone:
(213) 740-6243
Fax:
(213) 740-0853

Education

  • B.S., Yale University, 1961.
  • Ph.D., Rockefeller University, 1969.

Selected Publications

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Finch CE, Morgan TE, Longo VD, de Magalhaes JP. Cell resilience in specieslife spans: a link to inflammation? Aging Cell. 2010 Apr 23.

Morgan TE, Davis DA, Iwata N, Tanner JA, Snyder D, Ning Z, Kam W, Hsu YT,
Winkler JW, Chen JC, Petasis NA, Baudry M, Sioutas C, Finch CE. Glutamatergic
neurons in rodent models respond to nanoscale particulate urban air pollutants in
vivo and in vitro. Environ Health Perspect. 2011 Apr 7;119(7):1003-9.
-PubMed

Nunez-Iglesias J, Liu CC, Morgan TE, Finch CE, Zhou XJ.  Joint genome-wideprofiling of miRNA and mRNA expression in Alzheimer's disease cortex revealsaltered miRNA regulation. PLoS One. 2010 Feb 1;5(2):e8898.

Finch CE.  Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition. Proc Natl Acad Sci U S A. 2010 Jan 26;107 Suppl 1:1718-24. -PubMed

Pan F, Chiu CH, Pulapura S, Mehan MR, Nunez-Iglesias J, Zhang K, Kamath K, Waterman MS, Finch CE, Zhou XJ. (2007) Gene Aging Nexus: a web database and data mining platform for microarray data on aging. Nucleic Acids Res. 35(Database issue):D756-9. -PubMed

Finch CE.  Evolution in health and medicine Sackler colloquium: Evolution ofthe human lifespan and diseases of aging: roles of infection, inflammation, and nutrition. Proc Natl Acad Sci U S A. 2010 Jan 26;107 Suppl 1:1718-24.

Wong AM, Rozovsky I, Arimoto JM, Du Y, Wei M, Morgan TE, Finch CE.  Progesterone influence on neurite outgrowth involves microglia. Endocrinology.2009 Jan;150(1):324-32. -PubMed

Crimmins EM, Finch CE. (2006) Infection, inflammation, height, and longevity. Proc Natl Acad Sci U S A. 103:498-503. -PubMed

Patel NV, Gordon MN, Connor KE, Good RA, Engelman RW, Mason J, Morgan DG, Morgan TE, Finch CE. (2005) Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models.Neurobiol Aging. 26:995-1000 -PubMed

Rozovsky I, Wei M, Morgan TE, Finch CE (2005) Reversible age impairments in neurite outgrowth by manipulations of astrocytic GFAP. Neurobiol Aging. 26:705-15 -PubMed