University of Southern California

USC Neuroscience

Gerald E. Loeb

Professor of Biomedical Engineering,
Adj. Prof. Neurology, Pharmacy
Director of the Medical Device Development Facility,
Deputy Director, NSF Engineering Research Center for Biomimetic MicroElectronic Systems

Research Topics

  1. Neural prosthetics
  2. Sensorimotor control
  3. Muscle mechanics
  4. Spinal cord
  5. Haptic robots

Research Overview

We are interested generally in using electrophysiological interfaces between the nervous system and electronic equipment in order to understand natural functions (e.g. hearing, vision and movement) and to repair their disorders (e.g. deafness, blindness and paralysis). Previously, I have worked on cochlear implants (now commercially successful) and a cortical visual prosthesis (now being pursued by other research groups). Our current research is focused on reanimating or replacing paralyzed muscles and amputated limbs. This involves development of interface technologies (sensors, stimulators, etc.) and biomimetic control systems based on physiologically realistic mathematical models of muscles, proprioceptors and spinal cord circuitry. Such modeling builds on our many years of experimental research studying those structures in animals. We are also enhancing the haptic capabilities of mechatronic prosthetic limbs and industrial robots by incorporating biomimetic tactile sensors that we have developed and commercialized.

Contact Information

Web Sites:
BME Faculty
Medical Device Development Facility
SynTouch LLC
E-mail:
gloeb@usc.edu
Mailing Address:
University of Southern California
Denney Research Building B6, MC1111
1042 Downey Way
Los Angeles, CA 90089
Office Location:
DRB-B11, UPC
Office Phone:
(213) 821-5311
Lab Location:
DRB-B11, UPC
Lab Phone:
(213) 821-5311
Fax:
(213) 821-3897

Education

  • B.A., Johns Hopkins University, 1969
  • M.D., Johns Hopkins University, 1972
  • Surgical resident, University of Arizona, 1972-73

Research Images

Selected Publications

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Raphael G, Tsianos GA, Loeb GE. (2010) Spinal-like regulator facilitates control of a two degree-of-freedom wrist.  J. Neuroscience 30:9431-9444 -Link

Cheng EJ, Loeb GE. (2008) On the use of musculoskeletal models to interpret motor control strategies from performance data. J Neural Eng. 5(2):232-253. -PubMed

Song D, Raphael G, Lan N, Loeb GE. (2008)  Computationally efficient models of neuromuscular recruitment and mechanics. J Neural Eng. 2008 Jun;5(2):175-184. -PubMed

Song D, Lan N, Loeb GE, Gordon J. (2008)  Model-based sensorimotor integration for multi-joint control: development of a virtual arm model. Ann Biomed Eng. 2008 Jun;36(6):1033-1048. -PubMed

Popovic D, Baker LL, Loeb GE. (2007)  Recruitment and comfort of BION implanted electrical stimulation: implications for FES applications. IEEE Trans Neural Syst Rehabil Eng. 15(4):577-586. -PubMed

Davoodi R, Urata C, Hauschild M, Khachani M, Loeb GE. (2007)  Model-based development of neural prostheses for movement. IEEE Trans Biomed Eng. 54(11):1909-1918. -PubMed

Tan W, Loeb GE. (2007) Feasibility of prosthetic posture sensing via injectable electronic modules. IEEE Trans Neural Syst Rehabil Eng. 15(2):295-309. -PubMed

Sachs NA, Loeb GE. (2007)  Development of a BIONic muscle spindle for prosthetic proprioception. IEEE Trans Biomed Eng. 54(6 Pt 1):1031-1041. -PubMed

Hauschild M, Davoodi R, Loeb GE. (2007) A virtual reality environment for designing and fitting neural prosthetic limbs. IEEE Trans Neural Syst Rehabil Eng.15(1):9-15. -PubMed

Mileusnic MP, Brown I.E, Lan N, Loeb GE Mathematical models of proprioceptors: I. Control and transduction in the mscle spindle. J. Neurophysiol. 96:1772-1788, 2006.
-PubMed -Link