University of Southern California

USC Neuroscience

Valter D. Longo

Professor, Gerontology/Alzheimer's Research/Cancer Research, Biological Sciences

Research Topics

  1. Aging
  2. Cellular Neurobiology
  3. Microbial/Invertebrate Genetics
  4. Cancer

Research Overview

Dr. Longo is the Director of the Longevity Institute, a Professor of Gerontology and Biological Sciences and the Edna Jones Chair of Biogerontology. He is interested in understanding the mechanisms of aging in organisms ranging from yeast to humans. The focus is on the conserved nutrient signaling pathways that can be modulated to protect against age-dependent oxidative damage and delay or prevent diseases of aging including cancer, diabetes and neurodegenerative diseases. The neurobiology component of the laboratory focuses on genetic and dietary interventions to protect glial cells and neurons against oxidative stress and Alzheimer's disease. The cancer projects in the laboratory are focused on: a) dietary and genetic interventions for the differential protection and sensitization of normal and cancer cells with focus on stem cells and a variety of tumors. Several projects in the laboratory are "translational" and have both very basic and clinical components. For example, the laboratory is actively involved in several clinical trials to test the use of extreme diets to enhance cancer treatment.

Contact Information

Web Site:
Personal Home Page
E-mail:
vlongo@usc.edu
Office Location:
GER 319
Office Phone:
(213) 740-6212
Fax:
(213) 821-5714

Education

  • BS 1992 Biochemistry - University of North Texas
  • PhD 1997 Biochemistry - University of California, Los Angeles
  • 1997 University of California, Los Angeles
  • 1997-2000 University of Southern California, Los Angeles

Research Images

Selected Publications

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Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy.Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD.Sci Transl Med. 2012 Mar 7;4(124):124

 Extending the Healthy Life span: from yeast to humans. Fontana, L, Partridge, L., Longo VD. Science, April 16, 328, 321-6.

Shaday Michan, Ying Li, Maggie Meng-Hsiu Chou, Edoardo Parrella, Huanying Ge, Jeffrey M. Long, Joanne S. Allard, Kaitlyn Lewis, Marshall Miller, Wei Xu, Ronald F. Mervis, Jing Chen, Karen I. Guerin, Lois E. H. Smith, Michael W. McBurney, David A. Sinclair, Michel Baudry, Rafael de Cabo, and Valter D. Longo. SIRT1 is essential for normal cognitive function and synaptic plasticity, Journal of Neuroscience, 2010, Jul 21 (29):9695-707.

 

 Wei, M., Fabrizio, P., Chen, C., and Longo VD. Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. PLoS Genetics. May 2009.

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.

Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD.

Sci Transl Med. 2011 Feb 16;3(70)