University of Southern California

USC Neuroscience

Sarah F. Hamm-Alvarez

PIBBS MENTOR

Professor

Pharmaceutical Sciences, Physiology & Biophysics, Ophthalmology
Keck School of Medicine
School of Pharmacy

Research Topics

  1. Cell Structure & Organization
  2. Membranes & Transport
  3. Vision Research
  4. Drug Design
  5. Delivery
  6. Physiology

Research Overview

Contact Information

E-mail:
shalvar@usc.edu
Mailing Address:
9121 HSC
Office Location:
PSC 704
Office Phone:
(323) 442-1445
Fax:
(323) 442-1390

Education

  • BA 1986 Chemistry - Carleton College, Northfield, Minnesota
  • PhD 1990 Biochemistry - Duke University, Durham, North Carolina
  • Postdoctoral Research Fellowship:
  • 1990 - 1993 Duke University, Durham, North Carolina

Selected Publications

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Hamm-Alvarez SF, Janga SR, Edman MC, Madrigal S, Shah M, Frousiakis SE, Renduchintala K, Zhu J, Bricel S, Silka K, Bach D, Heur M, Christianakis S, Arkfeld DG, Irvine J, Mack WJ, Stohl W.  TEAR CATHEPSIN S AS A CANDIDATE BIOMARKER FOR SJOGREN'S SYNDROME.  Arthritis Rheumatol [2014] Jul;66(7):1872-1881. -PubMed -Link

Chiang L,Ngo J,Schechter JE,Karvar S,Tolmachova T,Seabra MC,Hume AN,Hamm-Alvarez SF - RAB27B REGULATES EXOCYTOSIS OF SECRETORY VESICLES IN ACINAR EPITHELIAL CELLS FROM THE LACRIMAL GLAND. - Am J Physiol Cell Physiol [2011] Apr 27;() -PubMed -Link

Li X,Wu K,Edman M,Schenke-Layland K,MacVeigh-Aloni M,Janga SR,Schulz B,Hamm-Alvarez SF - Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse. - Invest Ophthalmol Vis Sci [2010] Oct;51(10):5019-29 -Link

Contreras J,Xie J,Chen YJ,Pei H,Zhang G,Fraser CL,Hamm-Alvarez SF - Intracellular uptake and trafficking of difluoroboron dibenzoylmethane-polylactide nanoparticles in HeLa cells. - ACS Nano [2010] May 25;4(5):2735-47 -Link

Yacobi NR,Malmstadt N,Fazlollahi F,DeMaio L,Marchelletta R,Hamm-Alvarez SF,Borok Z,Kim KJ,Crandall ED - Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. - Am J Respir Cell Mol Biol [2010] May;42(5):604-14 -Link

Schenke-Layland K,Xie J,Magnusson M,Angelis E,Li X,Wu K,Reinhardt DP,Maclellan WR,Hamm-Alvarez SF - Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy. - Exp Eye Res [2010] Feb;90(2):223-37 -Link

Kim YH,Fazlollahi F,Kennedy IM,Yacobi NR,Hamm-Alvarez SF,Borok Z,Kim KJ,Crandall ED - Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure. - Am J Respir Crit Care Med [2010] Dec 1;182(11):1398-409

Wu K,Joffre C,Li X,MacVeigh-Aloni M,Hom M,Hwang J,Ding C,Gregoire S,Bretillon L,Zhong JF,Hamm-Alvarez SF - Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland. - Exp Eye Res [2009] Sep;89(3):319-32 -Link

Xie J,Marchelletta RR,Thomas PB,Jacobs DT,Yarber FA,Cheney RE,Hamm-Alvarez SF,Trousdale MD - Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol. - Exp Eye Res [2009] Mar;88(3):467-78 -Link

Joo KI,Lei Y,Lee CL,Lo J,Xie J,Hamm-Alvarez SF,Wang P - Site-specific labeling of enveloped viruses with quantum dots for single virus tracking. - ACS Nano [2008] Aug;2(8):1553-62 -Link