Daniel P Holschneider
Associate Professor/Dept. of Psychiatry and the Behavioral Sciences, and the Depts. of Neurology, Cell & Neurobiology, and Biomedical Engineering
Research Topics
- Functional brain mapping of animal behaviors
- Behavioral and neurophysiologic characterization of animal models of neuropsychiatric disorders
- Technology development
Research Overview
RESEARCH INTERESTS: The focus of the laboratory is on functional brain mapping in awake, nonrestrained animals of behaviors that are difficult to examine with conventional neuroimaging protocols (PET, SPECT, fMRI) as these require sedation and restraint of the subject--interventions which eliminate all but the most basic behaviors. To aid in this task, we have designed and validated the use of an implantable, miniature, infusion pump (MIP) for the administration of radiotracers by remote activation in freely moving animals. Current work focuses on the miniaturization of the MIP for use in mice, as well as developing the MIP as an interface for use with novel radiotracers to allow an expanded use of PET for functional neuroimaging in freely-moving animals. A complimentary area of active work is the development of methods of analysis of autoradiographic brain sections obtained from rodents. Ongoing projects include those evaluating the reorganization of brain function in response to lesions (Parkinsons models, traumatic brain injury, cerebral ischemia) and exercise training, projects evaluating functional brain activation in response to visceral pain (sex differences, fear conditioned visceral pain), a project evaluating the response of the brain to fearful stimuli in adult life after prior exposure to prenatal stress, and the characterization of the conditioned fear response in mice lacking the serotonin transporter.The expertise of the laboratory include functional brain mapping, animal behavior, physiologic monitoring (EEG, EMG, EKG) and basic histochemistry.
Contact Information
- Web Site:
- Laboratory of Vertebrate Functional Brain Mapping
- E-mail:
- holschne@usc.edu
- Mailing Address:
- Laboratory of Vertebrate Functional Brain Mapping
University of Southern California
Keck School of Medicine
Dept. of Cell and Neurobiology
1333 San Pablo St., BMT 403, MC 9112
McKibben Annex, MCA-B1
Los Angeles, CA 90089-9112
- Office Location:
- MCH B2
- Office Phone:
- (323) 442-1536
- Lab Location:
- MCH B1
- Lab Phone:
- (323)442-1585
- Fax:
- (323) 442-1587
Education
- 1984 The Johns Hopkins Univ., Baltimore, MD, B.A.
- 1988 Univ. North Carolina, Chapel Hill, NC, MD
- 1990 Mount Zion Hospital (UCSF), San Francisco, CA, Internal Med. Internship
- 1993 UCLA Neuropsychiatric Institute, Psychiatry Residency
- 1994 UCLA Neuropsychiatric Institute, Geriatric Psychiatry Fellowship
Research Images
Selected Publications
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Holschneider DP, Maarek JM. (2008) Brain maps on the go: Functional imaging during motor challenge in animals. Methods. 2008 Jun 10. (In press). -PubMed
Holschneider DP., Yang J., Sadler TR., Galifianakis NB., Bozorgzadeh MH., Bading JR., Conti PS., Maarek J-MI. (2008, in press), Changes in Regional Brain Perfusion During Functional Brain Activation: Comparison of [64Cu]-PTSM with [14C]-Iodoantipyrine, Brain Research.
Wang Z., Bradesi S., Maarek J-MI., Lee K., Winchester WJ., Mayer EA., Holschneider DP. (2008) Regional Brain Activation in Conscious, Unrestrained Rats in Response to Noxious Visceral Stimulation, Pain. 138(1):233-243. -PubMed -Link
Holschneider DP., Yang J., Guo Y., Maarek J-MI. (2007) Reorganization of Functional Brain Maps After Exercise Training: Importance of Cerebellar-Thalamic-Cortical Pathway, Brain Research, 1184:96-107. -PubMed -Link
Moore WH., Holschneider DP., Givrad T., Maarek J-MI. (2006) Powering Of An Implantable Minipump By A Radiofrequency Power Link To An External Resonating Inductive Coil Driven By A Class-E Transmitter, IEEE Transactions on Biomedical Engineering, 53(8):1-3. -PubMed -Link
Holschneider DP., Yang J, Sadler TS., Nguyen PT., Givrad TK., Maarek JM. (2006) Mapping Cerebral Blood Flow Changes During Auditory Conditioned Fear in the Nontethered, Nonrestrained Rat. Neuroimage, 15;29(4):1344-58. -PubMed -Link
Chen K., Holschneider DP., Wu W., Rebrin I., Shih JC. (2004) A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior. Journal of Biological Chemistry; 279(38):39645-52. -PubMed -Link
Nguyen PT., Holschneider DP., Maarek J-MI., Yang J., Mandelkern MA. (2004) Statistical Parametric Mapping Applied to an Autoradiographic Study of Cerebral Activation During Treadmill Walking in Rats. Neuroimage, 23:252-259. -PubMed -Link
Holschneider DP., Maarek J., Harimoto J., Yang J., Scremin OU. (2002) An Implantable Bolus Infusion Pump For Use In Freely Moving, Nontethered Rats. American Journal of Physiology 283(4):H1713-19. -PubMed -Link
Holschneider DP., Scremin OU., Chialvo D., Chen K., Shih JC. (2002) Heart Rate Dynamics in Monoamine Oxidase -A and -B Deficient Mice. American Journal of Physiology 282(5):H1751-9. -PubMed -Link