USC logo
University of Southern California
PIBBS Online ApplicationPIBBS CalendarContact PIBBSPIBBS Faculty DirectoryPIBBS Site Index
PIBBS Home PageFaculty ResearchFaculty DirectoryPhD ProgramsOnline Application
Research Centers and Institutes Faculty Research Support Seminars and Symposia PIBBS Faculty in the News


Shahab Asgharzadeh

Assistant Professor

Pediatrics (Division of Hematology-Oncology),
Childrens Hospital Los Angeles

Send E-mail to:   shahab@chla.usc.edu 
Telephone: 323-361-8643Fax: 323-361-9455
Office: CHL 54Mail Code: 0000 OTH

Education:
BS 1992 Biomedical Engineering - Northwestern University, Evanston, IL
MD 1996 Medicine - University of Illinois, Chicago, IL

Postdoctoral Research Fellowship:
1996-1999 University Of Chicago, IL

Started at USC: 2001

Research Topics: Cancer Genetics, Cancer Prevention/Epidemiology, Cancer Cell Biology, Bioinformatics

Click here for:PubMed Search Research KeywordsSearch USC for Professor Asgharzadeh

See also:     All USC Research GrantsAll HSC Research Grants

Research Description

My research program is involved in the areas of pediatric neural tumors, gene expression profiling and genomic aberrations analysis. A large portion of this work focuses on the examination of gene expression profiles and genomic profiles (DNA copy number changes and loss of heterozygosity) of tumors and their use as tools in assessing prognosis of children with neural tumors and understanding the pathogenesis of these disorders.

Our primary aim is to develop gene chip based risk stratification models that can be clinically applicable in children with neuroblastoma, a tumor of the sympathetic nervous system, and medulloblastoma, a common brain tumor. In this approach Affymetrix Exon and SNP arrays are used to identify transcript isoforms and DNA copy number/genotype of tumors. These genetic features will then be used in building prediction models for risk of disease relapse. In other areas, we are investigating genomic aspects of immune and inflammatory mechanisms occurring in the tumor microenvironment that can eradicate, control, and promote tumor growth and progression. This second aim will use the genomic data (data mining) to understand the impact of genomics on immune and inflammatory cells interactions with tumor cells and how these contribute to tumor eradication or progression.


Selected Publications

Maris JM, Mosse YP, Bradfield JP, Hou C, Monni S, Scott RH, Asgharzadeh S, Attiyeh EF, Diskin SJ, Laudenslager M, Winter C, Cole KA, Glessner JT, Kim C, Frackelton EC, Casalunovo T, Eckert AW, Capasso M, Rappaport EF, McConville C, London WB, Seeger RC, Rahman N, Devoto M, Grant SF, Li H, Hakonarson H. - Chromosome 6p22 Locus Associated with Clinically Aggressive Neuroblastoma. - N Engl J Med [ 2008 ] May 7; . PubMed

Gardner SL, Asgharzadeh S, Green A, Horn B, McCowage G, Finlay J. - Intensive induction chemotherapy followed by high dose chemotherapy with autologous hematopoietic progenitor cell rescue in young children newly diagnosed with central nervous system atypical teratoid rhabdoid tumors. - Pediatr Blood Cancer [ 2008 ] Apr 1; . PubMed

Pique-Regi R, Monso-Varona J, Ortega A, Seeger RC, Triche TJ, Asgharzadeh S. - Sparse representation and Bayesian detection of genome copy number alterations from microarray data. - Bioinformatics [ 2008 ] Feb 1;24(3):309-18 . PubMed

Fangusaro J, Finlay J, Sposto R, Ji L, Saly M, Zacharoulis S, Asgharzadeh S, Abromowitch M, Olshefski R, Halpern S, Dubowy R, Comito M, Diez B, Kellie S, Hukin J, Rosenblum M, Dunkel I, Miller DC, Allen J, Gardner S. - Intensive chemotherapy followed by consolidative myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) in young children with newly diagnosed supratentorial primitive neuroectodermal tumors (sPNETs): report of the Head Start I and II experience. - Pediatr Blood Cancer [ 2008 ] Feb;50(2):312-8 . PubMed

Zacharoulis S, Levy A, Chi SN, Gardner S, Rosenblum M, Miller DC, Dunkel I, Diez B, Sposto R, Ji L, Asgharzadeh S, Hukin J, Belasco J, Dubowy R, Kellie S, Termuhlen A, Finlay J. - Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue. - Pediatr Blood Cancer [ 2007 ] Jul;49(1):34-40 . PubMed

Asgharzadeh S, Pique-Regi R, Sposto R, Wang H, Yang Y, Shimada H, Matthay K, Buckley J, Ortega A, Seeger RC. - Prognostic significance of gene expression profiles of metastatic neuroblastomas lacking MYCN gene amplification. - J Natl Cancer Inst [ 2006 ] Sep 6;98(17):1193-203 . PubMed

Metelitsa LS, Wu HW, Wang H, Yang Y, Warsi Z, Asgharzadeh S, Groshen S, Wilson SB, Seeger RC. - Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2. - J Exp Med [ 2004 ] May 3;199(9):1213-21 . PubMed


NCBI Disclaimers and copyright notice
Last updated: Mon Jun 30 16:26:25 2008

Return to   PIBBS home page  |  Research Topics page
  For more information contact the PIBBS Program

University of Southern California
1975 Zonal Avenue KAM-B16
Los Angeles, California 90089-9031
323-442-1609 (voice) / 323-442-1199 (fax)
E-mail: pibbs@usc.edu
 
 
© 1998-2008 The University of Southern California
 ..