| Send E-mail to: shahab@chla.usc.edu | | | Telephone: 323-361-8643 | Fax: 323-361-9455 | | Office: CHL 54 | Mail Code: 0000 OTH |
Education:
BS 1992 Biomedical Engineering - Northwestern University, Evanston, IL
MD 1996 Medicine - University of Illinois, Chicago, IL
Postdoctoral Research Fellowship:
1996 - 1999 University Of Chicago, IL
Started at USC: 2001 Research Topics: Cancer Genetics, Cancer Prevention/Epidemiology, Cancer Cell Biology, Bioinformatics
Research Description My research program is involved in the areas of pediatric neural tumors, gene expression profiling and genomic aberrations analysis. A large portion of this work focuses on the examination of gene expression profiles and genomic profiles (DNA copy number changes and loss of heterozygosity) of tumors and their use as tools in assessing prognosis of children with neural tumors and understanding the pathogenesis of these disorders. Our primary aim is to develop gene chip based risk stratification models that can be clinically applicable in children with neuroblastoma, a tumor of the sympathetic nervous system, and medulloblastoma, a common brain tumor. In this approach Affymetrix Exon and SNP arrays are used to identify transcript isoforms and DNA copy number/genotype of tumors. These genetic features will then be used in building prediction models for risk of disease relapse. In other areas, we are investigating genomic aspects of immune and inflammatory mechanisms occurring in the tumor microenvironment that can eradicate, control, and promote tumor growth and progression. This second aim will use the genomic data (data mining) to understand the impact of genomics on immune and inflammatory cells interactions with tumor cells and how these contribute to tumor eradication or progression.
10 Selected Publications:
Click here to view all the publications for this faculty
Capasso M,Devoto M,Hou C,Asgharzadeh S,Glessner JT,Attiyeh EF,Mosse YP,Kim C,Diskin SJ,Cole KA,Bosse K,Diamond M,Laudenslager M,Winter C,Bradfield JP,Scott RH,Jagannathan J,Garris M,McConville C,London WB,Seeger RC,Grant SF,Li H,Rahman N,Rappaport E,Hakonarson H,Maris JM - Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. - Nat Genet [2009] May 3;(): PubMed
Song L,Asgharzadeh S,Salo J,Engell K,Wu HW,Sposto R,Ara T,Silverman AM,Declerck YA,Seeger RC,Metelitsa LS - Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages. - J Clin Invest [2009] May 1;(): PubMed
Huang S,Laoukili J,Epping MT,Koster J,Hölzel M,Westerman BA,Nijkamp W,Hata A,Asgharzadeh S,Seeger RC,Versteeg R,Beijersbergen RL,Bernards R - ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. - Cancer Cell [2009] Apr 7;15(4):328-40 PubMed
Pique-Regi R,Ortega A,Asgharzadeh S - Joint estimation of copy number variation and reference intensities on multiple DNA arrays using GADA. - Bioinformatics [2009] Mar 10;(): PubMed
Chen QR,Song YK,Wei JS,Bilke S,Asgharzadeh S,Seeger RC,Khan J - An integrated cross-platform prognosis study on neuroblastoma patients. - Genomics [2008] Oct;92(4):195-203 PubMed
Maris JM,Mosse YP,Bradfield JP,Hou C,Monni S,Scott RH,Asgharzadeh S,Attiyeh EF,Diskin SJ,Laudenslager M,Winter C,Cole KA,Glessner JT,Kim C,Frackelton EC,Casalunovo T,Eckert AW,Capasso M,Rappaport EF,McConville C,London WB,Seeger RC,Rahman N,Devoto M,Grant SF,Li H,Hakonarson H - Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. - N Engl J Med [2008] Jun 12;358(24):2585-93 PubMed
Gardner SL,Asgharzadeh S,Green A,Horn B,McCowage G,Finlay J - Intensive induction chemotherapy followed by high dose chemotherapy with autologous hematopoietic progenitor cell rescue in young children newly diagnosed with central nervous system atypical teratoid rhabdoid tumors. - Pediatr Blood Cancer [2008] Aug;51(2):235-40 PubMed
Pique-Regi R,Monso-Varona J,Ortega A,Seeger RC,Triche TJ,Asgharzadeh S - Sparse representation and Bayesian detection of genome copy number alterations from microarray data. - Bioinformatics [2008] Feb 1;24(3):309-18 PubMed
Fangusaro J,Finlay J,Sposto R,Ji L,Saly M,Zacharoulis S,Asgharzadeh S,Abromowitch M,Olshefski R,Halpern S,Dubowy R,Comito M,Diez B,Kellie S,Hukin J,Rosenblum M,Dunkel I,Miller DC,Allen J,Gardner S - Intensive chemotherapy followed by consolidative myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) in young children with newly diagnosed supratentorial primitive neuroectodermal tumors (sPNETs): report of the Head Start I and II experience. - Pediatr Blood Cancer [2008] Feb;50(2):312-8 PubMed
Asgharzadeh S,Pique-Regi R,Sposto R,Wang H,Yang Y,Shimada H,Matthay K,Buckley J,Ortega A,Seeger RC - Prognostic significance of gene expression profiles of metastatic neuroblastomas lacking MYCN gene amplification. - J Natl Cancer Inst [2006] Sep 6;98(17):1193-203 PubMed
| |
