Education:
BS 1966 Sciences - Lycee Lalande, Bourg-en-Bress, France
Eng 1971 Chemistry - Ecole Polytechnique, Paris, France
PhD 1977 Biochemistry - University of Paris VII, France
Postdoctoral Research Fellowship:
1978 - 1980 University of California, Irvine
Started at USC: 1989
Research Topics: Learning & Memory
Research Description
Mechanisms implicated in long-term synaptic potentiation and depression in hippocampus and other brain regions. My laboratory has been investigating for several years the molecular and cellular mechanisms underlying LTP and LTD phenomena in adult rats and rabbits. We have been using a combination of electrophysiological, neurochemical and neuroanatomical techniques to study the roles of various biochemical processes in regulating short-term as well as long-term changes in synaptic efficacy.
Regulation of glutamate receptors. My laboratory has been studying post-translational mechanisms regulating the properties of the AMPA and NMDA receptors. In particular, we are investigating the mechanisms involved in the maturation, processing, insertion and internalisation of the receptors. We are also evaluating the role of calpain-mediated truncation of the C-terminal domains of certain subunits of the receptors in receptor function and regulation.
Role of oxygen free radicals in central nervous system. As a result of my association with Eukarion, Inc., a small start-up pharmaceutical company in Bedford, MA., my laboratory has been investigating the roles of oxygen free radicals in neurodegenerative phenomena. In particular, we have tested the protective effects of a new class of synthetic catalytic scavengers of reactive oxygen intermediates on neuronal damage elicited by excitotoxins, neurotoxins, and beta-amyloid peptides.
Mechanisms underlying selective neuronal degeneration. In collaboration with Dr. Steve Schreiber, we have been interested in studying molecular and cellular mechanisms underlying selective neuronal degeneration resulting from neuronal insults or injury. In particular, we have been identifying a number of genes activated as a result of intense neuronal activity in neuronal populations selectively damaged under these conditions. Using a combination of pharmacology and selective suppression of the expression of these genes, we are evaluating their contribution to neuronal death resulting from programmed cell death or apoptosis.
My laboratory is also involved in several program projects:
. Human Brain Project: under this program project, my laboratory is developing new tools to incorporate neurochemical/neuroanatomical data into a large Neuroscience Database. In particular, we have developed tools to analyze autoradiographic as well as immunohistochenistry images in reference to a 3D-rat brain Atlas.
. Estrogen and Alzheimer's disease: under this program project, my laboratory is investigating the mechanisms underlying the potential neuroprotective of estrogen and related steroids in Alzheimer's disease.
. Neural tissue/silicon chips interfaces: in collaboration with Dr. Ted Berger, my laboratory is evaluating new technologies to record/stimulate neuronal activity of large ensemble of neurons.
10 Selected Publications:
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Jourdi H,Hsu YT,Zhou M,Qin Q,Bi X,Baudry M - Positive AMPA receptor modulation rapidly stimulates BDNF release and increases dendritic mRNA translation. - J Neurosci [2009] Jul 8;29(27):8688-97 PubMed
Qin Q,Baudry M,Liao G,Noniyev A,Galeano J,Bi X - A novel function for p53: regulation of growth cone motility through interaction with Rho kinase. - J Neurosci [2009] Apr 22;29(16):5183-92 PubMed
Zhou M,Xu W,Liao G,Bi X,Baudry M - Neuroprotection against neonatal hypoxia/ischemia-induced cerebral cell death by prevention of calpain-mediated mGluR1alpha truncation. - Exp Neurol [2009] Apr 14;(): PubMed
Jourdi H,Hamo L,Oka T,Seegan A,Baudry M - BDNF Mediates the Neuroprotective Effects of Positive AMPA Receptor Modulators Against MPP(+)-induced Toxicity in Cultured Hippocampal and Mesencephalic Slices. - Neuropharmacology [2009] Jan 20;(): PubMed
Dominguez R,Hu E,Zhou M,Baudry M - 17beta-estradiol-mediated neuroprotection and ERK activation require a pertussis toxin-sensitive mechanism involving GRK2 and beta-arrestin-1. - J Neurosci [2009] Apr 1;29(13):4228-38 PubMed
Aguirre CC,Baudry M - Progesterone reverses 17beta-estradiol-mediated neuroprotection and BDNF induction in cultured hippocampal slices. - Eur J Neurosci [2009] Jan 17;(): PubMed
Foy MR,Baudry M,Diaz Brinton R,Thompson RF - Estrogen and hippocampal plasticity in rodent models. - J Alzheimers Dis [2008] Dec;15(4):589-603 PubMed
Zhou M,Baudry M - EUK-207, a superoxide dismutase/catalase mimetic, is neuroprotective against oxygen/glucose deprivation-induced neuronal death in cultured hippocampal slices. - Brain Res [2009] Jan 9;1247():28-37 PubMed
Liao G,Zhou M,Cheung S,Galeano J,Nguyen N,Baudry M,Bi X - Reduced early hypoxic/ischemic brain damage is associated with increased GLT-1 levels in mice expressing mutant (P301L) human tau. - Brain Res [2009] Jan 9;1247():159-70 PubMed
Bouteiller JM,Baudry M,Allam SL,Greget RJ,Bischoff S,Berger TW - Modeling glutamatergic synapses: insights into mechanisms regulating synaptic efficacy. - J Integr Neurosci [2008] Jun;7(2):185-97 PubMed
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