| Send E-mail to: sbellusci@chla.usc.edu | | | Telephone: 323-361-5467 | Fax: 323-361-8096 | | Office: CHL 35 | Mail Code: 0000 OTH |
Education:
BS 1989 Biochemistry - University of Paris VII, France
PhD 1994 Biochemistry - University of Paris VII, France
Postdoctoral Research Fellowship:
1995 - 1998 Vanderbilt University, Nashville, Tennessee
Started at USC: 2002 Research Topics: Developmental Biology
Research Description The main focus of my laboratory is to determine the molecular basis of branching morphogenesis in the lung using transgenic and knock out mice. We were the first to report the important role of Fibroblast Growth factor 10 in directing lung epithelial budding. FGF10 acts through FGFR2b, expressed in the epithelium, to trigger chemotaxis and proliferation. We are actually trying to define the signaling network of epithelial-mesenchymal interaction regulating branching. This network involves members of the Bone Morphogenetic Protein, Hedgehog and Wnt families. Recently, we also became interested in the role of FGF10, secreted by the dermamyotome of the somites in the control of mammary placode formation. Our goal is to try to characterize the network of interaction, between the usual players mentioned above, in the formation of the mammary line in mouse.
10 Selected Publications:
Click here to view all the publications for this faculty
Tiozzo C,De Langhe S,Carraro G,Al Alam D,Nagy A,Wigfall C,Hajihosseini MK,Warburton D,Minoo P,Bellusci S - FGF10 (Fibroblast Growth Factor 10) plays a causative role in the tracheal cartilage defects in a mouse model of Apert Syndrome. - Pediatr Res [2009] Jul 1;(): PubMed
Tai CC,Sala FG,Ford HR,Wang KS,Li C,Minoo P,Grikscheit TC,Bellusci S - Wnt5a Knock-out Mouse as a New Model of Anorectal Malformation. - J Surg Res [2009] May 8;(): PubMed
Tiozzo C,De Langhe S,Yu M,Londhe VA,Carraro G,Li M,Li C,Xing Y,Anderson S,Borok Z,Bellusci S,Minoo P - Deletion of Pten Expands Lung Epithelial Progenitor Pools and Confers Resistance to Airway Injury. - Am J Respir Crit Care Med [2009] Jul 2;(): PubMed
Carraro G,El-Hashash A,Guidolin D,Tiozzo C,Turcatel G,Young BM,De Langhe SP,Bellusci S,Shi W,Parnigotto PP,Warburton D - miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. - Dev Biol [2009] Jun 25;(): PubMed
Tai CC,Curtis JL,Sala FG,Del Moral PM,Chokshi N,Kanard RJ,Al Alam D,Wang J,Burns RC,Ford HR,Grishin A,Wang KS,Bellusci S - Induction of fibroblast growth factor 10 (FGF10) in the ileal crypt epithelium after massive small bowel resection suggests a role for FGF10 in gut adaptation. - Dev Dyn [2009] Feb;238(2):294-301 PubMed
Carraro G,Perin L,Sedrakyan S,Giuliani S,Tiozzo C,Lee J,Turcatel G,De Langhe SP,Driscoll B,Bellusci S,Minoo P,Atala A,De Filippo RE,Warburton D - Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. - Stem Cells [2008] Nov;26(11):2902-11 PubMed
Warburton D,Perin L,Defilippo R,Bellusci S,Shi W,Driscoll B - Stem/progenitor cells in lung development, injury repair, and regeneration. - Proc Am Thorac Soc [2008] Aug 15;5(6):703-6 PubMed
Xing Y,Li C,Hu L,Tiozzo C,Li M,Chai Y,Bellusci S,Anderson S,Minoo P - Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2.1 and Pten. - Dev Biol [2008] Aug 15;320(2):340-50 PubMed
Bellusci S - Lung stem cells in the balance. - Nat Genet [2008] Jul;40(7):822-4 PubMed
Parsa S,Ramasamy SK,De Langhe S,Gupte VV,Haigh JJ,Medina D,Bellusci S - Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling. - Dev Biol [2008] May 1;317(1):121-31 PubMed
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