| Send E-mail to: sbouret@chla.usc.edu | |
| Telephone: 323-361-8743 | Fax: 323-671-1549 |
| Office: CHL 135 | Mail Code: 0000 OTH |
Education:
BS 1996 Biochemistry - University of Reims, France
MS 1998 Biology - University of Lille, France
PhD 2001 - University of Lille, France
Postdoctoral Research Fellowship:
2001 - 2004 Oregon Health and Science University, Beaverton, OR
Started at USC: 2006
Research Topics: Cellular Neurobiology
Research Description
Neural networks necessary for many instinctive behaviors and physiological functions are formed primarily during the perinatal period under the influence of what appear to be activity independent developmental mechanisms. When an individual is confronted with environmental conditions that differ markedly from those present during perinatal development, however, disorders can ensue. This seems to be particularly true for prevalence of obesity. Epidemiological evidence indicates that alterations in perinatal nutrition (e.g. caloric restriction and overfeeding) can predispose an individual toward obesity and associated diseases such as type 2 diabetes, especially in an environment with wide availability of calorie dense foods. Despite these observations, little is known about the underlying mechanisms mediating this metabolic imprinting. Our general research interest is to understand how neural networks controlling energy balance develop as well as to investigate the long-term consequences of their abnormal development on metabolism.
10 Selected Publications:
Click here to view all the publications for this faculty
Bouret SG - Early life origins of obesity: role of hypothalamic programming. - J Pediatr Gastroenterol Nutr [2009] Mar;48 Suppl 1():S31-8 PubMed
Patterson CM,Bouret SG,Dunn-Meynell AA,Levin BE - Three-weeks of post-weaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling. - Am J Physiol Regul Integr Comp Physiol [2009] Jan 21;(): PubMed
Bouret S,Richmond BJ - Relation of locus coeruleus neurons in monkeys to pavlovian and operant behaviors. - J Neurophysiol [2009] Feb;101(2):898-911 PubMed
Bouret SG - Crossing the border: developmental regulation of leptin transport to the brain. - Endocrinology [2008] Mar;149(3):875-6 PubMed
Bouret SG,Gorski JN,Patterson CM,Chen S,Levin BE,Simerly RB - Hypothalamic neural projections are permanently disrupted in diet-induced obese rats. - Cell Metab [2008] Feb;7(2):179-85 PubMed
Prevot V,Dehouck B,Poulain P,Beauvillain JC,Buée-Scherrer V,Bouret S - Neuronal-glial-endothelial interactions and cell plasticity in the postnatal hypothalamus: implications for the neuroendocrine control of reproduction. - Psychoneuroendocrinology [2007] Aug;32 Suppl 1():S46-51 PubMed
Bouret SG,Simerly RB - Development of leptin-sensitive circuits. - J Neuroendocrinol [2007] Aug;19(8):575-82 PubMed
Bouret SG,Simerly RB - Developmental programming of hypothalamic feeding circuits. - Clin Genet [2006] Oct;70(4):295-301 PubMed
Gohlke BC,Huber A,Bartmann P,Fimmers R,Hecher K,Bouret SG,Roth CL - Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins. - J Pediatr Endocrinol Metab [2006] Jan;19(1):3-9 PubMed
Bouret SG,Draper SJ,Simerly RB - Trophic action of leptin on hypothalamic neurons that regulate feeding. - Science [2004] Apr 2;304(5667):108-10 PubMed
|
