Education:
BA(Honors) 1979 Psychobiology - University of Arizona
MA 1981 Neuropsychology - University of Arizona
PhD 1984 Psychobiology & Neuropharmacology - University of Arizona
Postdoctoral Research Fellowship:
1984 - 1987 Rockefeller University, New York
Started at USC: 1988
Research Topics: Cellular Neurobiology, Neurogenetics, Pharmacology, Learning & Memory, Aging
Research Description
Our research has two levels of expression, elucidation of fundamental cellular mechanisms of cognitive function and the application of those principles to the discovery and design of therapeutic molecules and devices for the treatment of disorders of the nervous system. Our research team is currently focused on design of an estrogen replacement therapy for the brain, neurogenesis from neural stem cells, design of molecules for the treatment of learning disability, DNA repair in neurons and regulation of the immune response in brain. For further details regarding our ongoing research projects, our research team and publications the reader is referred to the Brinton Laboratory web site at http://pharmweb.usc.edu/brinton-lab/.
For those interested in science education outreach efforts by USC Life Science Graduate Students please see the USC Science, Technology and Research - STAR Program web site at http://www.usc.edu/hsc/USCSTAR/.
10 Selected Publications:
Click here to view all the publications for this faculty
Yao J,Irwin RW,Zhao L,Nilsen J,Hamilton RT,Brinton RD - Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease. - Proc Natl Acad Sci U S A [2009] Aug 10;(): PubMed
Liu L,Wang J,Zhao L,Nilsen J,McClure K,Wong K,Brinton RD - Progesterone increases rat neural progenitor cell cycle gene expression and proliferation via ERK and Progesterone Receptor Membrane Components (PGRMC) 1 and 2. - Endocrinology [2009] Apr 9;(): PubMed
Brinton RD - Estrogen-induced plasticity from cells to circuits: predictions for cognitive function. - Trends Pharmacol Sci [2009] Mar 17;(): PubMed
Asthana S,Brinton RD,Henderson VW,McEwen BS,Morrison JH,Schmidt PJ,for the Frontiers Proposal for Estrogen and Cognitive Aging Work Groups - Frontiers proposal. National Institute on Aging "bench to bedside: estrogen as a case study" - Age (Dordr) [2009] Mar 10;(): PubMed
Foy MR,Baudry M,Diaz Brinton R,Thompson RF - Estrogen and hippocampal plasticity in rodent models. - J Alzheimers Dis [2008] Dec;15(4):589-603 PubMed
Wang JM,Brinton RD - Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential. - BMC Neurosci [2008] Dec 3;9 Suppl 2():S11 PubMed
Zhao L,Mao Z,Brinton RD - A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo. - Endocrinology [2009] Feb;150(2):770-83 PubMed
Brinton RD - The healthy cell bias of estrogen action: mitochondrial bioenergetics and neurological implications. - Trends Neurosci [2008] Oct;31(10):529-37 PubMed
Brinton RD - Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer's disease. - Adv Drug Deliv Rev [2008] Oct-Nov;60(13-14):1504-11 PubMed
Brinton RD,Thompson RF,Foy MR,Baudry M,Wang J,Finch CE,Morgan TE,Pike CJ,Mack WJ,Stanczyk FZ,Nilsen J - Progesterone receptors: form and function in brain. - Front Neuroendocrinol [2008] May;29(2):313-39 PubMed
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