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| Send E-mail to: cadenas@usc.edu | | | Telephone: 323-442-1418 | Fax: 323-224-7473 | | Office: PSC 612 | Mail Code: 9121 HSC |
Education:
MD 1974 Medicine - University of Buenos Aires, Argentina
PhD 1977 Biochemistry - University of Buenos Aires, Argentina
Postdoctoral Research Fellowship:
1978 - 1980 University of Pennsylvania, Philadelphia, Johnson Research Foundation
Started at USC: 1989 Research Topics: Signal Transduction, Toxicology
Research Description The anomalous regulation of apoptosis has been recognized as a pathological process that occurs in a variety of conditions comprising neurodegenerative diseases, autoimmune disorders, and various cancers. We are interested in elucidating the molecular mechanisms underlying cell signaling pathways inherent in mitochondrion-dependent apoptosis and with implications for neurodegenerative- and age-related disorders. Ongoing research projects within these long-term goals are: (a) the study of the potential biological role of mitochondria as an important cellular target of pro-apoptotic JNK signalling involving modulation of Bcl-2 family members; (b) the regulation of mitochondrial functions by nitric oxide and the mitochondrial nitric oxide synthase and how they impinge on the cellular redox state; (c) analysis of the mitochondrial proteome for post-translational modifications caused by JNK activity and exposure to oxidative and nitrosative stress; (d) the analysis of the mechanism of actions of neuroprotective agents in terms of preserving mitochondrion functional integrity through activation of ligand-independent signaling pathways and universal transcription factors.
10 Selected Publications:
Click here to view all the publications for this faculty
Antico Arciuch VG,Galli S,Franco MC,Lam PY,Cadenas E,Carreras MC,Poderoso JJ - Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression. - PLoS One [2009] Oct 21;4(10):e7523 PubMed
Hamm-Alvarez S,Cadenas E - Mitochondrial medicine and therapeutics, Part II. - Adv Drug Deliv Rev [2009] Oct 14;(): PubMed
Yap LP,Garcia JV,Han D,Cadenas E - The energy-redox axis in aging and age-related neurodegeneration. - Adv Drug Deliv Rev [2009] Aug 27;(): PubMed
Lam PY,Yin F,Hamilton RT,Boveris A,Cadenas E - Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production. - Free Radic Res [2009] Apr 4;():1-9 PubMed
Zhou Q,Lam PY,Han D,Cadenas E - Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging. - FEBS Lett [2009] Mar 9;(): PubMed
Lam PY,Cadenas E - Compromised proteasome degradation elevates neuronal nitric oxide synthase levels and induces apoptotic cell death. - Arch Biochem Biophys [2008] Oct 15;478(2):181-6 PubMed
Hamm-Alvarez S,Cadenas E - Mitochondrial medicine and mitochondrion-based therapeutics. - Adv Drug Deliv Rev [2008] Oct-Nov;60(13-14):1437-8 PubMed
Galli S,Antico Arciuch VG,Poderoso C,Converso DP,Zhou Q,Bal de Kier Joffé E,Cadenas E,Boczkowski J,Carreras MC,Poderoso JJ - Tumor cell phenotype is sustained by selective MAPK oxidation in mitochondria. - PLoS ONE [2008] Jun 11;3(6):e2379 PubMed
Irwin RW,Yao J,Hamilton RT,Cadenas E,Brinton RD,Nilsen J - Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. - Endocrinology [2008] Jun;149(6):3167-75 PubMed
Packer L,Cadenas E,Davies KJ - Free radicals and exercise: an introduction. - Free Radic Biol Med [2008] Jan 15;44(2):123-5 PubMed
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