Yang ChaiGeorge and MaryLou Boone Professor
Director, Center for Craniofacial Molecular Biology
School of Dentistry |  |
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| Send E-mail to: ychai@usc.edu | |
| Telephone: 323-442-3480 | Fax: 323-442-2981 |
| Office: CSA 103 | Mail Code: 9062 HSC |
Education:
DMD(MB) 1984 Stomatology - Beijing Medical University, Beijing, China
PhD 1991 Craniofacial Biology - University of Southern California, Los Angeles
DDS 1996 Dentistry - University of Southern California, Los Angeles
Postdoctoral Research Fellowship:
1991 - 1994 University of Southern California, Los Angeles
Started at USC: 1987
Research Topics: Developmental Biology
Research Description
RESEARCH PROJECTS ONGOING OR COMPLETED DURING THE LAST 3 YEARS
"Center for Craniofacial Molecular Biology"
. Principal Investigator for Project 4: Yang Chai, DDS, PhD
. Agency: National Institute of Dental and Craniofacial Research, NIH
. Type: P50 DE09165; Period: September 20, 1989 to September 19, 1999
. The integrated and complementary scientific research projects in this center grant, using recombinant DNA technology, genetics, biochemistry, developmental biology, mouse animal models, cell and organ culture. and computer-assisted molecular modeling, provide substantial molecular inforn1ation towards understanding the etiology and molecular pathogenesis of congenital craniofacial malformations.
"TGF-ß signaling and mandibular morphogenesis"
. Principal Investigator: Yang Chai, DDS, PhD
. Agency: National Institute of Dental and Craniofacial Research, NIH
. Type: R01 DE12711; Period: January 1,1999 to December 31, 2003
. The major goal of this project is to identify and determine the critical molecules in TGF- ß signaling pathway and how TGF- ß signaling regulates the expression of transcription factor Lefl during the specification and morphogenesis of tooth, Meckel's cartilage and tongue.
"Craniofacial Developmental Molecular Biology"
. Principal Investigator for Project 1: Yang Chai, DDS, PhD
. Agency: National Institute of Dental and Craniofacial Research, NIH
. Type: P01 DE12941; Period: August 1, 1999 to July 31,2004
. The major goal of this project is to identify how growth factor signaling can regulate the expression of transcription factors during tooth and cartilage formation by using the first arch explant as a study model. And how genetic mutations of the molecules in this pathway can lead to craniofacial malformations.
10 Selected Publications:
Click here to view all the publications for this faculty
Huang X,Xu X,Bringas P,Hung YP,Chai Y - Smad4-Shh-Nfic Signaling Cascade-Mediated Epithelial-Mesenchymal Interaction is Crucial in Regulating Tooth Root Development. - J Bone Miner Res [2009] Nov 5;(): PubMed
Huang X,Bringas P Jr,Slavkin HC,Chai Y - Fate of HERS during tooth root development. - Dev Biol [2009] Jul 1;(): PubMed
Li F,Zeng B,Chai Y,Cai P,Fan C,Cheng T - The linker region of Smad2 mediates TGF-beta-dependent ERK2-induced collagen synthesis. - Biochem Biophys Res Commun [2009] May 21;(): PubMed
Chung IH,Yamaza T,Zhao H,Choung PH,Shi S,Chai Y - Stem Cell Property of Postmigratory Cranial Neural Crest Cells and Their Utility in Alveolar Bone Regeneration and Tooth Development. - Stem Cells [2009] Jan 15;27(4):866-877 PubMed
Shi S,Chai Y,Slavkin H - Emerging opportunities for the next generation of dental implants? - Dent Today [2009] Mar;28(3):98-9 PubMed
Zhang Z,Lan Y,Chai Y,Jiang R - Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. - Science [2009] Feb 27;323(5918):1232-4 PubMed
Hosokawa R,Deng X,Takamori K,Xu X,Urata M,Bringas P Jr,Chai Y - Epithelial-specific requirement of FGFR2 signaling during tooth and palate development. - J Exp Zoolog B Mol Dev Evol [2009] Feb 23;(): PubMed
Xu X,Han J,Ito Y,Bringas P Jr,Deng C,Chai Y - Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. - Dev Cell [2008] Aug;15(2):322-9 PubMed
Zhao H,Oka K,Bringas P,Kaartinen V,Chai Y - TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner. - Dev Biol [2008] Aug 1;320(1):19-29 PubMed
Chen H,Zhuang F,Liu YH,Xu B,Del Moral P,Deng W,Chai Y,Kolb M,Gauldie J,Warburton D,Moses HL,Shi W - TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. - Eur Respir J [2008] Aug;32(2):285-95 PubMed
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