| Send E-mail to: jeannie@usc.edu | | | Telephone: 323-442-4479 | Fax: 323-442-4433 | | Office: ZNI 235 | Mail Code: 2821 HSC |
Education:
BA 1983 Biochemistry - Occidental College, Los Angeles, California
PhD 1990 Biochemistry - University of Southern California
Postdoctoral Research Fellowship:
1991 - 1995 California Institute of Technology, Pasadena
Started at USC: 1995 Research Topics: Signal Transduction, Vision Research, Membranes & Transport, Developmental Biology
Research Description My lab is investigating the molecular mechanism of G-protein signaling in photoreceptor cells. We are making exciting progress on understanding how that signal is processed, such as how the signal is turned off when light is no longer present, and how the cell adapts to different intensities of light. We apply a multidisciplinary approach in our studies, combining transgenic mouse technology with electrophysiological, biochemical and morphological analyses. One important outcome of our studies on basic retinal processes is that along the way, we have created mouse models of retinal degeneration. These animal models are being used to study the disease process on the molecular level. We are applying gene chip and protein chip technologies to decipher the complex nature of disease etiology and combining this with detailed biochemical, electrophysiological and morphological analyses. This multi-disciplinary approach will help us better understand the disease process so that rational intervention can be designed.
10 Selected Publications:
Click here to view all the publications for this faculty
Knutsen T,Padilla-Nash HM,Wangsa D,Barenboim-Stapleton L,Camps J,McNeil N,Difilippantonio MJ,Ried T - Definitive molecular cytogenetic characterization of 15 colorectal cancer cell lines. - Genes Chromosomes Cancer [2009] Nov 19;(): PubMed
Gulten T,Yakut T,Karkucak M,Baytan B,Meral Gunes A - AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemia. - J Clin Lab Anal [2009] Nov 19;23(6):368-371 PubMed
Cazier JB,Tomlinson I - General lessons from large-scale studies to identify human cancer predisposition genes. - J Pathol [2009] Nov 19;(): PubMed
Abou Jamra R,Schulze TG,Becker T,Brockschmidt FF,Green E,Alblas MA,Wendland JR,Adli M,Grozeva D,Strohmeier J,Georgi A,Craddock N,Propping P,Rietschel M,Nöthen MM,Cichon S,Schumacher J - A systematic association mapping on chromosome 6q in bipolar affective disorder-evidence for the melanin-concentrating-hormone-receptor-2 gene as a risk factor for bipolar affective disorder. - Am J Med Genet B Neuropsychiatr Genet [2009] Nov 19;(): PubMed
Zhang W,Sun SG,Jiang YH,Qiao X,Sun X,Wu Y - Determination of brain iron content in patients with Parkinson's disease using magnetic susceptibility imaging. - Neurosci Bull [2009] Dec;25(6):353-360 PubMed
He KW,Shen LL,Zhou WW,Wang DY - Regulation of aging by unc-13 and sbt-1 in Caenorhabditis elegans is temperature-dependent. - Neurosci Bull [2009] Dec;25(6):335-342 PubMed
Makarasara W,Kumasaka N,Assawamakin A,Takahashi A,Intarapanich A,Ngamphiw C,Kulawonganunchai S,Ruangrit U,Fucharoen S,Kamatani N,Tongsima S - pHCR: a Parallel Haplotype Configuration Reduction algorithm for haplotype interaction analysis. - J Hum Genet [2009] Nov 20;(): PubMed
Peprah E,He W,Allen E,Oliver T,Boyne A,Sherman SL - Examination of FMR1 transcript and protein levels among 74 premutation carriers. - J Hum Genet [2009] Nov 20;(): PubMed
Sim EU,Ang CH,Ng CC,Lee CW,Narayanan K - Differential expression of a subset of ribosomal protein genes in cell lines derived from human nasopharyngeal epithelium. - J Hum Genet [2009] Nov 20;(): PubMed
Zhao T,Zhang D,Liu Y,Zhou D,Chen Z,Yang Y,Li S,Yu L,Zhang Z,Feng G,He L,Xu H - Association between ESR1 and ESR2 gene polymorphisms and hyperlipidemia in Chinese Han postmenopausal women. - J Hum Genet [2009] Nov 20;(): PubMed
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