Education:
BSc 1970 Chemistry/Physiology - University of Potchefstroom, South Africa
BSc(Hon.) 1972 Biochemistry - University of Potchefstroom, South Africa
MSc 1973 Med. Biochemistry - University of Stellenbosch, South Africa
PhD 1977 Med. Biochemistry - University of Stellenbosch, South Africa
Postdoctoral Research Fellowship:
1978 Hadassah University Hospital, Israel
Started at USC: 1989 Research Topics: Cancer Genetics, Signal Transduction, Endocrinology/Metabolism, Molecular Epidemiology, Gene Regulation/Transcription
Research Description
Gerhard (Gerry) A. Coetzee, Ph.D.
Professor of Urology, Preventive Medicine and Molecular Microbiology & Immunology
Research Topics: Cancer Genetics, Endocrinology, Steroid Receptors, and Transcription
Dr. Coetzee has 30 years of molecular biology experience. He is the co-leader of the Genitourinary Cancers program of the Norris Cancer Center. He is currently leading an NIH-funded research study on the role of the steroid receptors in prostate and breast cancer predisposition and progression. Major findings during the past decade include the role of polymorphisms in the androgen receptor (AR) gene and prostate cancer predisposition, the role of AR signaling in ablation-resistant prostate cancer, and more recently genome-wide AR occupancy, including associated modified histone signatures. He is currently using these techniques to identify regulatory sequences at loci affecting prostate cancer predisposition (risk). Recently his lab discovered the first androgen-dependent enhancers at 8q24 that affected transcriptional regulation related to prostate cancer risk.
10 Selected Publications:
Click here to view all the publications for this faculty
Jia L,Landan G,Pomerantz M,Jaschek R,Herman P,Reich D,Yan C,Khalid O,Kantoff P,Oh W,Manak JR,Berman BP,Henderson BE,Frenkel B,Haiman CA,Freedman M,Tanay A,Coetzee GA - Functional enhancers at the gene-poor 8q24 cancer-linked locus. - PLoS Genet [2009] Aug;5(8):e1000597 PubMed
Peters AA,Buchanan G,Ricciardelli C,Bianco-Miotto T,Centenera MM,Harris JM,Jindal S,Segara D,Jia L,Moore NL,Henshall SM,Birrell SN,Coetzee GA,Sutherland RL,Butler LM,Tilley WD - Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer. - Cancer Res [2009] Aug 1;69(15):6131-40 PubMed
Pomerantz MM,Ahmadiyeh N,Jia L,Herman P,Verzi MP,Doddapaneni H,Beckwith CA,Chan JA,Hills A,Davis M,Yao K,Kehoe SM,Lenz HJ,Haiman CA,Yan C,Henderson BE,Frenkel B,Barretina J,Bass A,Tabernero J,Baselga J,Regan MM,Manak JR,Shivdasani R,Coetzee GA,Freedman ML - The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. - Nat Genet [2009] Aug;41(8):882-4 PubMed
Baniwal SK,Khalid O,Sir D,Buchanan G,Coetzee GA,Frenkel B - Repression of Runx2 by Androgen Receptor (AR) in Osteoblasts and Prostate Cancer Cells: AR Binds Runx2 and Abrogates its Binding to DNA. - Mol Endocrinol [2009] Apr 23;(): PubMed
Berman BP,Frenkel B,Coetzee GA - Location, location, (ChIP-)location! Mapping chromatin landscapes one immunoprecipitation at a time. - J Cell Biochem [2009] Mar 23;(): PubMed
Jariwala U,Cogan JP,Jia L,Frenkel B,Coetzee GA - Inhibition of AR-mediated transcription by binding of Oct1 to a motif enriched in AR-occupied regions. - Prostate [2009] Mar 1;69(4):392-400 PubMed
Jia L,Berman BP,Jariwala U,Yan X,Cogan JP,Walters A,Chen T,Buchanan G,Frenkel B,Coetzee GA - Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity. - PLoS ONE [2008] ;3(11):e3645 PubMed
Khalid O,Baniwal SK,Purcell DJ,Leclerc N,Gabet Y,Stallcup MR,Coetzee GA,Frenkel B - Modulation of Runx2 activity by estrogen receptor-alpha: implications for osteoporosis and breast cancer. - Endocrinology [2008] Dec;149(12):5984-95 PubMed
Buchanan G,Ricciardelli C,Harris JM,Prescott J,Yu ZC,Jia L,Butler LM,Marshall VR,Scher HI,Gerald WL,Coetzee GA,Tilley WD - Control of androgen receptor signaling in prostate cancer by the cochaperone small glutamine rich tetratricopeptide repeat containing protein alpha. - Cancer Res [2007] Oct 15;67(20):10087-96 PubMed
Prescott J,Jariwala U,Jia L,Cogan JP,Barski A,Pregizer S,Shen HC,Arasheben A,Neilson JJ,Frenkel B,Coetzee GA - Androgen receptor-mediated repression of novel target genes. - Prostate [2007] Sep 15;67(13):1371-83 PubMed
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