Education:
BS 1974 Physiology - University of Wisonsin, Wisconsin
MS 1977 Physiology - University of Wisconsin, Wisconsin
PhD 1981 Biochemistry & Biophysics - University of California at Berkeley, California
Postdoctoral Research Fellowship:
1981 - 1983 Harvard University, Boston, Massachusettes
Started at USC: 1983 Research Topics: Aging, Microbial/Invertebrate Genetics
Research Description Professor Davies' research centers on the role of free radicals and oxidative stress in biology. In particular he is interested in genes that repair oxidatively damaged proteins, lipids, RNA, and DNA, and his laboratory has made major contributions to our understanding of this subject over the past twenty years. At the Andrus Gerontology Center, Professor Davies is focusing his research on the regulation of oxidative stress repair genes during aging. His laboratory is involved in biochemical, molecular biology, and genetic studies of both normal aging processes, and aging pathologies such as Parkinson and Alzheimer's diseases.
10 Selected Publications:
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Ngo JK,Davies KJ - Mitochondrial Lon protease is a human stress protein. - Free Radic Biol Med [2009] Apr 15;46(8):1042-8 PubMed
Ermak G,Hench KJ,Chang KT,Sachdev S,Davies KJ - Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro. - J Biol Chem [2009] Mar 6;(): PubMed
Nogalska A,D'Agostino C,Engel WK,Davies KJ,Askanas V - Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers. - Neurobiol Aging [2008] Oct 13;(): PubMed
Sachdev S,Davies KJ - Production, detection, and adaptive responses to free radicals in exercise. - Free Radic Biol Med [2008] Jan 15;44(2):215-23 PubMed
Packer L,Cadenas E,Davies KJ - Free radicals and exercise: an introduction. - Free Radic Biol Med [2008] Jan 15;44(2):123-5 PubMed
Ngo JK,Davies KJ - Importance of the lon protease in mitochondrial maintenance and the significance of declining lon in aging. - Ann N Y Acad Sci [2007] Nov;1119():78-87 PubMed
Davies KJ,Ermak G,Rothermel BA,Pritchard M,Heitman J,Ahnn J,Henrique-Silva F,Crawford D,Canaider S,Strippoli P,Carinci P,Min KT,Fox DS,Cunningham KW,Bassel-Duby R,Olson EN,Zhang Z,Williams RS,Gerber HP,Pérez-Riba M,Seo H,Cao X,Klee CB,Redondo JM,Maltais LJ,Bruford EA,Povey S,Molkentin JD,McKeon FD,Duh EJ,Crabtree GR,Cyert MS,de la Luna S,Estivill X - Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. - FASEB J [2007] Oct;21(12):3023-8 PubMed
Brigelius-Flohé R,Davies KJ - Is vitamin E an antioxidant, a regulator of signal transduction and gene expression, or a 'junk' food? Comments on the two accompanying papers: "Molecular mechanism of alpha-tocopherol action" by A. Azzi and "Vitamin E, antioxidant and nothing more" by M. Traber and J. Atkinson. - Free Radic Biol Med [2007] Jul 1;43(1):2-3 PubMed
Harris CD,Ermak G,Davies KJ - RCAN1-1L is overexpressed in neurons of Alzheimer's disease patients. - FEBS J [2007] Apr;274(7):1715-24 PubMed
Powell SR,Davies KJ,Divald A - Optimal determination of heart tissue 26S-proteasome activity requires maximal stimulating ATP concentrations. - J Mol Cell Cardiol [2007] Jan;42(1):265-9 PubMed
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