Louis Dubeau Professor Pathology Keck School of Medicine

Education:
BS 1971 Biochemistry- McGill University Montreal, Canada
BA 1969 Biochemistry- McGill University Montreal, Canada
PhD 1981 Biochemistry- McGill University Montreal, Canada
MD 1979 Medicine- McGill University Montreal, Canada

Postdoctoral Research Fellowship:
1979-1980 McGill University, Montreal, Quebec, Canada
1985-1987 University of Southern California

Started at USC: 1987

Research Topics: Cancer Cell Biology, Cancer Genetics, Cancer Treatment, Cancer Prevention/Epidemiology

Research Description

Dr. Dubeau's primary research interest is molecular biology and genetics of ovarian cancer development.

Selected Publications

Dubeau L. - BRCA1-induced ovarian oncogenesis. - Adv Exp Med Biol [ 2008 ] 622:89-97 . PubMed

Johnson SA, Dubeau L, Johnson DL. - Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation. - J Biol Chem [ 2008 ] May 1; . PubMed

Dong D, Ni M, Li J, Xiong S, Ye W, Virrey JJ, Mao C, Ye R, Wang M, Pen L, Dubeau L, Groshen S, Hofman FM, Lee AS. - Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. - Cancer Res [ 2008 ] Jan 15;68(2):498-505 . PubMed

Yu J, Roy D, Brockmeyer AD, Dubeau L. - Increased chromosomal stability in cultures of ovarian tumours of low malignant potential compared to cystadenomas. - Br J Cancer [ 2007 ] Jun 18;96(12):1908-13 . PubMed

Shelbourne PF, Keller-McGandy C, Bi WL, Yoon SR, Dubeau L, Veitch NJ, Vonsattel JP, Wexler NS, Arnheim N, Augood SJ. - Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain. - Hum Mol Genet [ 2007 ] May 15;16(10):1133-42 . PubMed

Kumar SR, Masood R, Spannuth WA, Singh J, Scehnet J, Kleiber G, Jennings N, Deavers M, Krasnoperov V, Dubeau L, Weaver FA, Sood AK, Gill PS. - The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome. - Br J Cancer [ 2007 ] Apr 10;96(7):1083-91 . PubMed

Ehrlich M, Woods CB, Yu MC, Dubeau L, Yang F, Campan M, Weisenberger DJ, Long T, Youn B, Fiala ES, Laird PW. - Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors. - Oncogene [ 2006 ] Apr 27;25(18):2636-45 . PubMed

Li YF, Gauderman WJ, Avol E, Dubeau L, Gilliland FD. - Associations of tumor necrosis factor G-308A with childhood asthma and wheezing. - Am J Respir Crit Care Med [ 2006 ] May 1;173(9):970-6 . PubMed

Wenten M, Berhane K, Rappaport EB, Avol E, Tsai WW, Gauderman WJ, McConnell R, Dubeau L, Gilliland FD. - TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences. - Am J Respir Crit Care Med [ 2005 ] Dec 15;172(12):1563-8 . PubMed

Li YF, Tsao YH, Gauderman WJ, Conti DV, Avol E, Dubeau L, Gilliland FD. - Intercellular adhesion molecule-1 and childhood asthma. - Hum Genet [ 2005 ] Sep;117(5):476-84 . PubMed