| Send E-mail to: aepstein@usc.edu | |
| Telephone: 323-442-1172 | Fax: 323-442-3049 |
| Office: HMR 205 | Mail Code: 9092 HSC |
Education:
BA 1971 Biology - Wesleyan University, Middletown, CT.
PhD 1979 Cancer Biology - Stanford University, Stanford, CA
MD 1978 Medicine - Stanford University School of Medicine, Stanford, CA
Postdoctoral Research Fellowship:
1978-1980 Eleanor Roosevelt Institute for Cancer Research, University of Colorado Medical Center, Denver, CO.
Started at USC: 1984
Research Topics: Cancer Treatment, Immunology, Cancer Cell Biology
Research Description
Major Areas of Research Interest
Cell culture, heterotransplantation, cytogenetics, and biological characterization of the human malignant lymphomas and leukemias; Biochemistry and immunology of nuclear proteins; Production and clinical testing of monoclonal antibodies for the immunodiagnosis and therapy of cancer.
Research In Progress
Development of humanized TNT antibodies; generation of human antibody/fusion proteins consisting of human cytokines and chemokines for the immunotherapy of cancer; development of low toxicity human IL-2 mutant; generation of human vasopermeability antibody agent to enhance drug and antibody uptake in tumors; development of antibody/enzyme fusion proteins for ADEPT; development of TNT imaging agents for the detection of solid tumors.
Selected Publications
Sadun RE, Hsu WE, Zhang N, Nien YC, Bergfeld SA, Sabzevari H, Lutsiak ME, Khawli L, Hu P, Epstein AL. - Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models. - J Immunother [ 2008 ] Apr;31(3):235-45 . PubMed
Hu P, Arias RS, Sadun RE, Nien YC, Zhang N, Sabzevari H, Lutsiak ME, Khawli LA, Epstein AL. - Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer. - Clin Cancer Res [ 2008 ] Jan 15;14(2):579-88 . PubMed
Khawli LA, Hu P, Epstein AL. - Cytokine, chemokine, and co-stimulatory fusion proteins for the immunotherapy of solid tumors. - Handb Exp Pharmacol [ 2008 ] (181):291-328 . PubMed
Zhang N, Khawli LA, Hu P, Epstein AL. - Lym-1-induced apoptosis of non-Hodgkin's lymphomas produces regression of transplanted tumors. - Cancer Biother Radiopharm [ 2007 ] Jun;22(3):342-56 . PubMed
Sadun RE, Sachsman SM, Chen X, Christenson KW, Morris WZ, Hu P, Epstein AL. - Immune signatures of murine and human cancers reveal unique mechanisms of tumor escape and new targets for cancer immunotherapy. - Clin Cancer Res [ 2007 ] Jul 1;13(13):4016-25 . PubMed
Arias RS, Flanagan ML, Miller KD, Nien YC, Hu P, Gray D, Khawli LA, Epstein AL. - RA8, a human anti-CD25 antibody against human Treg cells. - Hybridoma (Larchmt) [ 2007 ] Jun;26(3):119-30 . PubMed
Zhang N, Sadun RE, Arias RS, Flanagan ML, Sachsman SM, Nien YC, Khawli LA, Hu P, Epstein AL. - Targeted and untargeted CD137L fusion proteins for the immunotherapy of experimental solid tumors. - Clin Cancer Res [ 2007 ] May 1;13(9):2758-67 . PubMed
Liu A, Hu P, Khawli LA, Epstein AL. - B7.1/NHS76: a new costimulator fusion protein for the immunotherapy of solid tumors. - J Immunother [ 2006 ] Jul-Aug;29(4):425-35 . PubMed
Flanagan ML, Khawli LA, Hu P, Epstein AL. - H60/TNT-3 fusion protein activates NK cells in vitro and improves immunotherapeutic outcome in murine syngeneic tumor models. - J Immunother [ 2006 ] May-Jun;29(3):274-83 . PubMed
Yu L, Ju DW, Chen W, Li T, Xu Z, Jiang C, Chen S, Tao Q, Ye D, Hu P, Khawli LA, Taylor CR, Epstein AL. - 131I-chTNT radioimmunotherapy of 43 patients with advanced lung cancer. - Cancer Biother Radiopharm [ 2006 ] Feb;21(1):5-14 . PubMed
