| Send E-mail to: hofman@usc.edu | | | Telephone: 323-442-1153 | Fax: 323-442-3049 | | Office: HMR 315 | Mail Code: 9092 HSC |
Education:
BS 1968 Biology - City College of New York
MS 1970 Zoology - University of Wisconsin (Madison)
PhD 1976 - Weizmann Institute, Israel
Postdoctoral Research Fellowship:
1976 - 1977 Kaplan/Hebrew University, Jerusalem
1977 - 1980 University of California, Los Angeles School of Medicine
Started at USC: 1980 Research Topics: Signal Transduction, Cardiovascular & Skeletal Muscle Diseases, Cancer Biology, Cellular Neurobiology
Research Description The current research interest in the laboratory is the functional characteristics of the vasculature present within in primary and metastatic brain tumors. We have made several novel observations regarding the structure and function of these tumor-associated brain endothelial cells derived from gliomas, using both in vitro and in vivo model systems. Our results show that tumor-associated endothelial cells are relatively resistant to apoptosis induced by a variety of chemotherapeutic agents. The mechanism(s) of this chemoresistance, and ways to sensitize these vascular cells to therapeutic agents is the focus of our studies.
10 Selected Publications:
Click here to view all the publications for this faculty
Virrey JJ,Golden EB,Sivakumar W,Wang W,Pen L,Schönthal AH,Hofman FM,Chen TC - Glioma-associated endothelial cells are chemoresistant to temozolomide. - J Neurooncol [2009] Apr 18;(): PubMed
Cho HY,Thomas S,Golden EB,Gaffney KJ,Hofman FM,Chen TC,Louie SG,Petasis NA,Schönthal AH - Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress. - Cancer Lett [2009] Apr 2;(): PubMed
Zandian M,Belisle R,Mott KR,Nusinowitz S,Hofman FM,Ghiasi H - A recombinant HSV-1 expressing murine interleukin-2 induces optic neuritis in different strains of mice. - Invest Ophthalmol Vis Sci [2009] Feb 21;(): PubMed
Jabbour MN,Elder JB,Samuelson CG,Khashabi S,Hofman FM,Giannotta SL,Liu CY - Aberrant angiogenic characteristics of human brain arteriovenous malformation endothelial cells. - Neurosurgery [2009] Jan;64(1):139-46; discussion 146-8 PubMed
Virrey JJ,Dong D,Stiles C,Patterson JB,Pen L,Ni M,Schönthal AH,Chen TC,Hofman FM,Lee AS - Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells. - Mol Cancer Res [2008] Aug;6(8):1268-75 PubMed
Virrey JJ,Guan S,Li W,Schönthal AH,Chen TC,Hofman FM - Increased survivin expression confers chemoresistance to tumor-associated endothelial cells. - Am J Pathol [2008] Aug;173(2):575-85 PubMed
Kardosh A,Golden EB,Pyrko P,Uddin J,Hofman FM,Chen TC,Louie SG,Petasis NA,Schönthal AH - Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib. - Cancer Res [2008] Feb 1;68(3):843-51 PubMed
Schönthal AH,Chen TC,Hofman FM,Louie SG,Petasis NA - Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs. - Expert Opin Investig Drugs [2008] Feb;17(2):197-208 PubMed
Pyrko P,Schönthal AH,Hofman FM,Chen TC,Lee AS - The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. - Cancer Res [2007] Oct 15;67(20):9809-16 PubMed
Kardosh A,Soriano N,Pyrko P,Liu YT,Jabbour M,Hofman FM,Schönthal AH - Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib. - J Biomed Sci [2007] Sep;14(5):647-62 PubMed
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