Telephone: 323-442-1400
E-mail: elien@usc.edu
Webpage: http://www.usc.edu/hsc/pharmacy/pharmsci/lien.htm
Office: PSC 600
Mail Code: 9121 HSC

Education:
BS 1960 Pharmacy - National Taiwan University, Taiwan
PhD 1966 Pharmaceutical Chemistry - Univeristy of California at San Francisco, California

Postdoctoral Research Fellowship:
1967-1968 Pomona College, California

Started at USC: 1968

Research Topics: Drug Design, Delivery

PubMed Search

Research Keywords

Research Description

My major research interests include structure-activity relationship and drug design, physical organic chemistry and natural products. Ongoing research projects include design, synthesis, and testing of antiviral and anticancer agents; refinement of quantitative structure-activity relationship models for application in vivo and in vitro ; correlation of side effects and toxicities with molecular structures; isolation of bioactive natural products like immunostimulating polysaccharides from Chinese herbs. The overall emphasis is to apply the tools of SAR in the optimization of lead compounds obtained from screening tests or natural products, in terms of increased potency, efficacy and decreased adverse reactions and toxicities.

Selected Publications

Wang RB, Kuo CL, Lien LL, Lien EJ. Structure-activity relationship: analyses of p-glycoprotein substrates and inhibitors. J Clin Pharm Ther. [ 2003 ] Jun;28(3):203-28. PubMed

Wu H, Lien EJ, Lien LL. Chemical and pharmacological investigations of Epimedium species: a survey. Prog Drug Res. [ 2003 ] 60:1-57. PubMed

Ren S, Wang R, Komatsu K, Bonaz-Krause P, Zyrianov Y, McKenna CE, Csipke C, Tokes ZA, Lien EJ. Synthesis, biological evaluation, and quantitative structure-activity relationship analysis of new Schiff bases of hydroxysemicarbazide as potential antitumor agents. J Med Chem. [ 2002 ] Jan 17;45(2):410-9. PubMed

Ren S, Tokes ZA, Csipke C, Zhou B, Yen Y, Lien EJ. Inhibition of tumor cell growth by Schiff bases of hydroxysemicarbazide. Anticancer Res. [ 2001 ] Sep-Oct;21(5):3445-51. PubMed

Ren S, Lien EJ. Development of HIV protease inhibitors: a survey. Prog Drug Res. [ 2001 ] Spec No:1-34. PubMed

Lee AD, Ren S, Lien EJ. Purine analogs as CDK enzyme inhibitory agents: a survey and QSAR analysis. Prog Drug Res. [ 2001 ] 56:155-93. PubMed

de los Reyes GC, Koda RT, Lien EJ. Glucosamine and chondroitin sulfates in the treatment of osteoarthritis: a survey. Prog Drug Res. [ 2000 ] 55:81-103. PubMed

Ren S, Lien EJ. Caco-2 cell permeability vs human gastrointestinal absorption: QSPR analysis. Prog Drug Res. [ 2000 ] 54:1-23. PubMed

Das A, Trousdale MD, Ren S, Lien EJ. Inhibition of herpes simplex virus type 1 and adenovirus type 5 by heterocyclic Schiff bases of aminohydroxyguanidine tosylate. Antiviral Res. [ 1999 ] Dec 31;44(3):201-8. PubMed

Nandy P, Lien EJ, Avramis VI. Inhibition of ribonucleotide reductase by a new class of isoindole derivatives: drug synergism with cytarabine (Ara-C) and induction of cellular apoptosis. Anticancer Res. [ 1999 ] May-Jun;19(3A):1625-33. PubMed