Education:
BS 1992 Biochemistry - University of North Texas
PhD 1997 Biochemistry - University of California, Los Angeles
Postdoctoral Research Fellowship:
1997 University of California, Los Angeles
1997-2000 University of Southern California, Los Angeles
Started at USC: 1999
Research Topics: Aging, Cellular Neurobiology, Microbial/Invertebrate Genetics
Research Description
Dr. Longo is an Assistant Professor of Gerontology and Biological Sciences and the Paul Glenn Chair of Biogerontology. He is interested in understanding the mechanisms of aging in yeast and in the mammalian brain. The focus is on the molecular pathways conserved from simple organisms to humans that can be modulated to protect against age-dependent oxidative damage and delay or prevent diseases of aging. Dr. Longo is also interested in the role of oxidants in neurotoxicity and Alzheimer's Disease. The laboratory studies various model systems including mammalian neurons and glial cells and the yeast Saccharomyces cerevisiae.
Selected Publications
Fabrizio P, Longo VD. - Chronological aging-induced apoptosis in yeast. - Biochim Biophys Acta [ 2008 ] Apr 10; . PubMed
Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD. - Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. - Proc Natl Acad Sci U S A [ 2008 ] Mar 31; . PubMed
Wei M, Fabrizio P, Hu J, Ge H, Cheng C, Li L, Longo VD. - Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. - PLoS Genet [ 2008 ] Jan;4(1):e13 . PubMed
Madia F, Gattazzo C, Wei M, Fabrizio P, Burhans WC, Weinberger M, Galbani A, Smith JR, Nguyen C, Huey S, Comai L, Longo VD. - Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. - J Cell Biol [ 2008 ] Jan 14;180(1):67-81 . PubMed
Cheng C, Fabrizio P, Ge H, Wei M, Longo VD, Li LM. - Significant and systematic expression differentiation in long-lived yeast strains. - PLoS ONE [ 2007 ] Oct 31;2(10):e1095 . PubMed
Fabrizio P, Longo VD. - The chronological life span of Saccharomyces cerevisiae. - Methods Mol Biol [ 2007 ] 371:89-95 . PubMed
Cheng C, Fabrizio P, Ge H, Longo VD, Li LM. - Inference of transcription modification in long-live yeast strains from their expression profiles. - BMC Genomics [ 2007 ] Jul 6;8:219 . PubMed
Madia F, Gattazzo C, Fabrizio P, Longo VD. - A simple model system for age-dependent DNA damage and cancer. - Mech Ageing Dev [ 2007 ] Jan;128(1):45-9 . PubMed
Longo VD, Kennedy BK. - Sirtuins in aging and age-related disease. - Cell [ 2006 ] Jul 28;126(2):257-68 . PubMed
Skulachev VP, Longo VD. - Aging as a mitochondria-mediated atavistic program: can aging be switched off? - Ann N Y Acad Sci [ 2005 ] Dec;1057:145-64 . PubMed
