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Education:
BS 1992 Biochemistry - University of North Texas
PhD 1997 Biochemistry - University of California, Los Angeles
Postdoctoral Research Fellowship:
1997 University of California, Los Angeles
1997 - 2000 University of Southern California, Los Angeles
Started at USC: 1999 Research Topics: Aging, Cellular Neurobiology, Microbial/Invertebrate Genetics
Research Description Dr. Longo is an Assistant Professor of Gerontology and Biological Sciences and the Paul Glenn Chair of Biogerontology. He is interested in understanding the mechanisms of aging in yeast and in the mammalian brain. The focus is on the molecular pathways conserved from simple organisms to humans that can be modulated to protect against age-dependent oxidative damage and delay or prevent diseases of aging. Dr. Longo is also interested in the role of oxidants in neurotoxicity and Alzheimer's Disease. The laboratory studies various model systems including mammalian neurons and glial cells and the yeast Saccharomyces cerevisiae.
10 Selected Publications:
Click here to view all the publications for this faculty
Ge H,Wei M,Fabrizio P,Hu J,Cheng C,Longo VD,Li LM - Comparative analyses of time-course gene expression profiles of the long-lived sch9{Delta} mutant. - Nucleic Acids Res [2009] Oct 30;(): PubMed
Wei M,Fabrizio P,Madia F,Hu J,Ge H,Li LM,Longo VD - Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. - PLoS Genet [2009] May;5(5):e1000467 PubMed
Longo VD,Lieber MR,Vijg J - Turning anti-ageing genes against cancer. - Nat Rev Mol Cell Biol [2008] Nov;9(11):903-10 PubMed
Parrella E,Longo VD - The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease. - Methods [2008] Dec;46(4):256-62 PubMed
Longo VD - Linking sirtuins, IGF-I signaling, and starvation. - Exp Gerontol [2009] Jan-Feb;44(1-2):70-4 PubMed
Li Y,Xu W,McBurney MW,Longo VD - SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons. - Cell Metab [2008] Jul;8(1):38-48 PubMed
Fabrizio P,Longo VD - Chronological aging-induced apoptosis in yeast. - Biochim Biophys Acta [2008] Jul;1783(7):1280-5 PubMed
Raffaghello L,Lee C,Safdie FM,Wei M,Madia F,Bianchi G,Longo VD - Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. - Proc Natl Acad Sci U S A [2008] Jun 17;105(24):8215-20 PubMed
Wei M,Fabrizio P,Hu J,Ge H,Cheng C,Li L,Longo VD - Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. - PLoS Genet [2008] Jan;4(1):e13 PubMed
Madia F,Gattazzo C,Wei M,Fabrizio P,Burhans WC,Weinberger M,Galbani A,Smith JR,Nguyen C,Huey S,Comai L,Longo VD - Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system. - J Cell Biol [2008] Jan 14;180(1):67-81 PubMed
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