Education:
BA 1976 Zoology - Trinity College University of Dubland Ireland
PhD 1980 Physiology/ Marine Biology - Univ. Wales, U.K.
Postdoctoral Research Fellowship:
1980 - 1983 University of Irvine, California
Started at USC: 1983
Research Topics: Marine Biology, Membranes & Transport, Developmental Biology, Evolutionary Biology, Microbial/Invertebrate Genetics
Research Description
The majority of marine animals have a larval stage of development as an intermediate between the egg and the adult stages. In spite of the obvious importance of larvae in the life cycles of marine animals, little is understood about the biology of these complex life history stages when compared to what is known about adult forms.
My specific area of research is the environmental physiology of development of marine invertebrates, especially the larval stages. Understanding growth and development of any animal in its environment, be it terrestrial or aquatic, is a very complex process. For species of marine animals, the problem of understanding the biology of larval stages is further complicated by the vast scales and different environments of the world's oceans over which life-history strategies are known to vary. The approaches being undertaken in my laboratory to study how larvae work are as follows:(1) to study the environmental biology of larvae at several different levels of analysis (e.g., ecology, physiology, biochemistry, and molecular biology)(2) to investigate a variety of phyla with species representing different life-history strategies (e.g., echinoderms, molluscs, annelids, and arthropods[in order of current emphasis in our laboratory])(3) to undertake comparative studies of similar species developing in very different oceanic environments (e.g., the cold polar oceans of Antarctica cf. the warmer ocean off California cf. deep-sea environments, such as hydrothermal vents).
10 Selected Publications:
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Leong P,Manahan D - Metabolic importance of Na+/K+-ATPase activity during sea urchin development. - J Exp Biol [1997] ;200(Pt 22):2881-92 PubMed
Welborn J,Manahan D - Taurine metabolism in larvae of marine invertebrate molluscs (Bilvalvia, Gastropoda) - J Exp Biol [1995] ;198(Pt 8):1791-9 PubMed
Hoegh-Guldberg O,Manahan D - Coulometric measurement of oxygen consumption during development of marine invertebrate embryos and larvae - J Exp Biol [1995] ;198(Pt 1):19-30 PubMed
Wright SH,Manahan DT - Integumental nutrient uptake by aquatic organisms. - Annu Rev Physiol [1989] ;51():585-600 PubMed
Meyer E,Manahan DT - Nutrient Uptake by Marine Invertebrates: Cloning and Functional Analysis of Amino Acid Transporter Genes in Developing Sea Urchins (Strongylocentrotus purpuratus). - Biol Bull [2009] Aug;217(1):6-24 PubMed
Pace DA,Manahan DT - Cost of protein synthesis and energy allocation during development of antarctic sea urchin embryos and larvae. - Biol Bull [2007] Apr;212(2):115-29 PubMed
Pace DA,Manahan DT - Fixed metabolic costs for highly variable rates of protein synthesis in sea urchin embryos and larvae. - J Exp Biol [2006] Jan;209(Pt 1):158-70 PubMed
Marsh AG,Mullineaux LS,Young CM,Manahan DT - Larval dispersal potential of the tubeworm Riftia pachyptila at deep-sea hydrothermal vents. - Nature [2001] May 3;411(6833):77-80 PubMed
Marsh AG,Maxson RE Jr,Manahan DT - High macromolecular synthesis with low metabolic cost in Antarctic sea urchin embryos. - Science [2001] Mar 9;291(5510):1950-2 PubMed
Leong PK,Manahan DT - Na+/K+-ATPase activity during early development and growth of an Antarctic sea urchin. - J Exp Biol [1999] Aug;202(Pt 15):2051-8 PubMed
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