| Send E-mail to: pmarjora@usc.edu | |
| Telephone: 323-442-0111 | Fax: 323-442-2349 |
| Office: CHP 220 | Mail Code: 9011 HSC |
Education:
BSc(Honors) 1984 Mathematics - Warwick University, Coventry, England
MS 1986 Mathematical Statistics - Cambridge University, Cambridge, England
PhD 1992 Applied Probability - University College London, University of London, England
Postdoctoral Research Fellowship:
1989 - 1992 Queen Mary College London, University of London, England
1992 - 1995 Monash University, Melbourne, Australia
Started at USC: 1995
Research Topics: Bioinformatics, Computational Biology
Research Description
My research involves the use of mathematical models for the evolution of organisms and their genes. We model the unobserved ancestry that relates all individuals, and helps explain their patterns of variation, in order to make inference about evolutionary parameters and events of interest. Such work involves the use of computationally intensive methods and simulation studies. Wherever possible, we prefer to simulate data rather than get our hands dirty with the real thing. Our current focus is on the fine-mapping of disease genes and the structure of the human genome.
10 Selected Publications:
Click here to view all the publications for this faculty
Siegmund KD,Marjoram P,Tavaré S,Shibata D - Many colorectal cancers are "flat" clonal expansions. - Cell Cycle [2009] Jul 15;8(14):2187-93 PubMed
Siegmund KD,Marjoram P,Woo YJ,Tavaré S,Shibata D - Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. - Proc Natl Acad Sci U S A [2009] Mar 4;(): PubMed
Chen GK,Marjoram P,Wall JD - Fast and flexible simulation of DNA sequence data. - Genome Res [2009] Jan;19(1):136-42 PubMed
Jiang R,Tavaré S,Marjoram P - Population genetic inference from resequencing data. - Genetics [2009] Jan;181(1):187-97 PubMed
Joyce P,Marjoram P - Approximately sufficient statistics and bayesian computation. - Stat Appl Genet Mol Biol [2008] ;7(1):Article26 PubMed
Siegmund KD,Marjoram P,Shibata D - Modeling DNA methylation in a population of cancer cells. - Stat Appl Genet Mol Biol [2008] ;7(1):Article 18 PubMed
Zhao K,Nordborg M,Marjoram P - Genome-wide association mapping using mixed-models: application to GAW15 Problem 3. - BMC Proc [2007] ;1 Suppl 1():S164 PubMed
Jung H,Zhao K,Marjoram P - Cladistic analysis of genotype data-application to GAW15 Problem 3. - BMC Proc [2007] ;1 Suppl 1():S125 PubMed
Padhukasahasram B,Marjoram P,Wall JD,Bustamante CD,Nordborg M - Exploring population genetic models with recombination using efficient forward-time simulations. - Genetics [2008] Apr;178(4):2417-27 PubMed
Simkhovich BZ,Marjoram P,Kleinman MT,Kloner RA - Direct and acute cardiotoxicity of ultrafine particles in young adult and old rat hearts. - Basic Res Cardiol [2007] Nov;102(6):467-75 PubMed
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