| Send E-mail to: pmarjora@usc.edu | |
| Telephone: 323-442-0111 | Fax: 323-442-2349 |
| Office: CHP 220 | Mail Code: 9011 HSC |
Education:
BSc (Honors) 1984 Mathematics - Warwick University, Coventry, England
MS 1986 Mathematical Statistics - Cambridge University, Cambridge, England
PhD 1992 Applied Probability - University College London, University of London, England
Postdoctoral Research Fellowship:
1989-1992 Queen Mary College London, University of London, England
1992-1995 Monash University, Melbourne, Australia
Started at USC: 1995
Research Topics: Bioinformatics, Computational Biology
Research Description
My research involves the use of mathematical models for the evolution of organisms and their genes. We model the unobserved ancestry that relates all individuals, and helps explain their patterns of variation, in order to make inference about evolutionary parameters and events of interest. Such work involves the use of computationally intensive methods and simulation studies. Wherever possible, we prefer to simulate data rather than get our hands dirty with the real thing. Our current focus is on the fine-mapping of disease genes and the structure of the human genome.
Selected Publications
Padhukasahasram B, Marjoram P, Wall JD, Bustamante CD, Nordborg M. - Exploring population genetic models with recombination using efficient forward-time simulations. - Genetics [ 2008 ] Apr;178(4):2417-27 . PubMed
Zhao K, Nordborg M, Marjoram P. - Genome-wide association mapping using mixed-models: application to GAW15 Problem 3. - BMC Proc [ 2007 ] 1 Suppl 1:S164 . PubMed
Jung H, Zhao K, Marjoram P. - Cladistic analysis of genotype data-application to GAW15 Problem 3. - BMC Proc [ 2007 ] 1 Suppl 1:S125 . PubMed
Simkhovich BZ, Marjoram P, Kleinman MT, Kloner RA. - Direct and acute cardiotoxicity of ultrafine particles in young adult and old rat hearts. - Basic Res Cardiol [ 2007 ] Nov;102(6):467-75 . PubMed
Vallbohmer D, Marjoram P, Kuramochi H, Shimizu D, Jung H, DeMeester SR, Oh D, Chandrasoma PT, Danenberg KD, DeMeester TR, Danenberg PV, Peters JH. - Towards the molecular characterization of disease: comparison of molecular and histological analysis of esophageal epithelia. - J Gastrointest Surg [ 2007 ] Sep;11(9):1095-104 . PubMed
Zhao K, Aranzana MJ, Kim S, Lister C, Shindo C, Tang C, Toomajian C, Zheng H, Dean C, Marjoram P, Nordborg M. - An Arabidopsis example of association mapping in structured samples. - PLoS Genet [ 2007 ] Jan 19;3(1):e4 . PubMed
Marjoram P, Tavaré S. - Modern computational approaches for analysing molecular genetic variation data. - Nat Rev Genet [ 2006 ] Oct;7(10):759-70 . PubMed
Padhukasahasram B, Wall JD, Marjoram P, Nordborg M. - Estimating recombination rates from single-nucleotide polymorphisms using summary statistics. - Genetics [ 2006 ] Nov;174(3):1517-28 . PubMed
Marjoram P, Chang J, Laird PW, Siegmund KD. - Cluster analysis for DNA methylation profiles having a detection threshold. - BMC Bioinformatics [ 2006 ] Jul 26;7:361 . PubMed
Jiang R, Marjoram P, Borevitz JO, Tavaré S. - Inferring population parameters from single-feature polymorphism data. - Genetics [ 2006 ] Aug;173(4):2257-67 . PubMed
