 |
| Send E-mail to: dshibata@usc.edu | | | Telephone: 323-865-0638 | Fax: 323-226-2686 | | Office: NOR 6410 | Mail Code: 9092 HSC |
Education:
BS 1977 Biochemistry - University of California, Los Angeles
MS 1979 Chemistry - University of California, San Diego
MD 1983 Medicine - University of Southern California School of Medicine
Postdoctoral Research Fellowship:
1983 - 1984 University of California, San Diego
Started at USC: 1989 Research Topics: Cancer Genetics, Evolutionary Biology, Computational Biology, DNA Replication, Repair, Modificatio, Epigenetics
Research Description Cancer is a multistep process involving unknown numbers of cell divisions and mutations. One great mystery is how many divisions and how many mutations. Although these numbers are fundamental to the understanding of cancer, it has been extremely difficult to obtain estimates in humans since serial observations are impractical and unethical. My laboratory is currently focused on using genetic analysis to determine when mutations are acquired and the number of divisions which intervene between tumor initiation and clinical presentation. We are exploring the concept of molecular tumor clocks and the general translation of well established phylogenetic approaches to cancer. By analogy to the "Out-of-Africa" problem, we seek to unravel the past to determine when individual human tumors arose "Out-of-Adenoma". Besides traditional techniques in molecular biology, we employ robotics to increase laboratory efficiency and are currently exploring the use of computers to simulate experiments. Computer simulations take minutes but help plan experiments which will take weeks of laboratory work.
10 Selected Publications:
Click here to view all the publications for this faculty
Siegmund KD,Marjoram P,Woo YJ,Tavaré S,Shibata D - Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. - Proc Natl Acad Sci U S A [2009] Mar 4;(): PubMed
Jiang X,Castelao JE,Groshen S,Cortessis VK,Shibata D,Conti DV,Yuan JM,Pike MC,Gago-Dominguez M - Urinary tract infections and reduced risk of bladder cancer in Los Angeles. - Br J Cancer [2009] Mar 10;100(5):834-9 PubMed
Woo YJ,Siegmund KD,Tavaré S,Shibata D - Older individuals appear to acquire mitotically older colorectal cancers. - J Pathol [2009] Mar;217(4):483-488 PubMed
Shibata D - Inferring human stem cell behaviour from epigenetic drift. - J Pathol [2009] Jan;217(2):199-205 PubMed
Shibata DK,Kern SE - Ancestral trees for modeling stem cell lineages genetically rather than functionally: understanding mutation accumulation and distinguishing the restrictive cancer stem cell propagation theory and the unrestricted cell propagation theory of human tumorigenesis. - Breast Dis [2008] ;29():15-25 PubMed
Jiang X,Castelao JE,Groshen S,Cortessis VK,Shibata DK,Conti DV,Gago-Dominguez M - Water intake and bladder cancer risk in Los Angeles County. - Int J Cancer [2008] Oct 1;123(7):1649-56 PubMed
Siegmund KD,Marjoram P,Shibata D - Modeling DNA methylation in a population of cancer cells. - Stat Appl Genet Mol Biol [2008] ;7(1):Article 18 PubMed
Basile LA,Gallaher TK,Shibata D,Miller JD,Douer D - Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice. - J Transl Med [2008] May 19;6():26 PubMed
Chu M,Siegmund KD,Hao QL,Crooks GM,Tavaré S,Shibata D - Inferring relative numbers of human leucocyte genome replications. - Br J Haematol [2008] Jun;141(6):862-71 PubMed
Alhopuro P,Phichith D,Tuupanen S,Sammalkorpi H,Nybondas M,Saharinen J,Robinson JP,Yang Z,Chen LQ,Orntoft T,Mecklin JP,Järvinen H,Eng C,Moeslein G,Shibata D,Houlston RS,Lucassen A,Tomlinson IP,Launonen V,Ristimäki A,Arango D,Karhu A,Sweeney HL,Aaltonen LA - Unregulated smooth-muscle myosin in human intestinal neoplasia. - Proc Natl Acad Sci U S A [2008] Apr 8;105(14):5513-8 PubMed
| |
NCBI Disclaimers and copyright notice
Last updated: Monday August 10th 10:10am 2009
Return to PIBBS home page | Research Topics page
|
