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| Send E-mail to: jcshih@usc.edu | | | Telephone: 323-442-1441 | Fax: 323-224-7473 | | Office: PSC 518 | Mail Code: 9121 HSC |
Education:
BS 1964 Biochemistry - National Taiwan University, Taiwan
PhD 1968 Biochemistry - University of California, Riverside
Postdoctoral Research Fellowship:
1968 - 1970 University of California, Los Angeles
Started at USC: 1974 Research Topics: Neurogenetics, Bioinformatics, Pharmacology, Signal Transduction
Research Description My research objectives are to understand the functions of monoamine neurotransmitters on transcriptional regulation of gene expression, signally transduction pathways and ultimately to behaviors. These studies will not only provide new knowledge on the molecular mechanisms of brain functions but also help us understand the molecular basis of mental disorders such as bipolar depression, schizophrenia, Alzheimer's and Parkinson's diseases. This information will be useful for designing novel therapeutic agents and early diagnosis of these diseases. Our research projects are focused on the regulation, structure and functions of monoamine oxidase isoenzymes and serotonin receptors. We are currently using DNA chips, proteomics and bioinformatic approaches to study the role of serotonin in the regulation of transcription factors and other gene expression in a series of MAO gene knock-out and transgenic mice, which exhibit different behaviors including anxiety and aggression. This information will be linked to human databases and help identify polymorphism and SNP in genes related to mental disorders.
10 Selected Publications:
Click here to view all the publications for this faculty
Kaludercic N,Takimoto E,Nagayama T,Feng N,Lai EW,Bedja D,Chen K,Gabrielson KL,Blakely RD,Shih JC,Pacak K,Kass DA,Di Lisa F,Paolocci N - Monoamine Oxidase A-Mediated Enhanced Catabolism of Norepinephrine Contributes to Adverse Remodeling and Pump Failure in Hearts With Pressure Overload. - Circ Res [2009] Nov 12;(): PubMed
Yin HS,Chen K,Shih JC,Tien TW - Down-Regulated GABAergic Expression in the Olfactory Bulb Layers of the Mouse Deficient in Monoamine Oxidase B and Administered With Amphetamine. - Cell Mol Neurobiol [2009] Nov 10;(): PubMed
Bortolato M,Godar SC,Davarian S,Chen K,Shih JC - Behavioral Disinhibition and Reduced Anxiety-like Behaviors in Monoamine Oxidase B-Deficient Mice. - Neuropsychopharmacology [2009] Aug 26;(): PubMed
Wu JB,Chen K,Li Y,Lau YF,Shih JC - Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. - FASEB J [2009] Aug 6;(): PubMed
Ou XM,Lu D,Johnson C,Chen K,Youdim MB,Rajkowska G,Shih JC - Glyceraldehyde-3-Phosphate Dehydrogenase-Monoamine Oxidase B-Mediated Cell Death-Induced by Ethanol is Prevented by Rasagiline and 1-R-Aminoindan. - Neurotox Res [2009] Aug;16(2):148-59 PubMed
Wu JB,Chen K,Ou XM,Shih JC - Retinoic acid activates monoamine oxidase B promoter in human neuronal cells. - J Biol Chem [2009] Apr 28;(): PubMed
Bortolato M,Chen K,Shih JC - Monoamine oxidase inactivation: from pathophysiology to therapeutics. - Adv Drug Deliv Rev [2008] Oct-Nov;60(13-14):1527-33 PubMed
Scott AL,Bortolato M,Chen K,Shih JC - Novel monoamine oxidase A knock out mice with human-like spontaneous mutation. - Neuroreport [2008] May 7;19(7):739-43 PubMed
Guo G,Ou XM,Roettger M,Shih JC - The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity. - Eur J Hum Genet [2008] May;16(5):626-34 PubMed
Shih JC - Monoamine oxidases: from tissue homogenates to transgenic mice. - Neurochem Res [2007] Oct;32(10):1757-61 PubMed
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