| Send E-mail to: mlsnead@usc.edu | |
| Telephone: 323-442-3178 | Fax: 323-442-2981 |
| Office: CSA 142 | Mail Code: 0641 HSC |
Education:
BS 1973 Biology/Chemistry - St. Mary's College, Moraga, CA
DDS 1977 Dentistry - Loyola University, College of Dental Surgery, Chicago, IL
PhD 1981 Pathology - The University of Chicago, Chicago, IL
Postdoctoral Research Fellowship:
1981 - 1982 Baylor College of Medicine, Hughes Medical Research Institute, Houston, TX
1982 - 1984 University of Southern California, School of Dentistry
Started at USC: 1984
Research Topics: Developmental Biology, Gene Regulation/Transcription
Research Description
RESEARCH PROJECTS ONGOING OR COMPLETED DURING THE LAST 3 YEARS
"Determination and Expression of Amelogenin Gene Products"
. Principal Investigator: Malcolm L Snead, D.D.S., Ph.D.
. Agency : National Institute of Dental and Craniofacial Research
. Type: P50 (DE06988, Years, 1-16) Period: July 30, 1985 to June 30, 2001
. The major goals of this project are to test the hypothesis that amelogenin gene regulation is dependent upon a cascade of signals provided during instructive secondary germ layer interaction serving to pattern oral epithelium to the ameloblast phenotype.
"VonEbner Gland Gene Products"
. Principal Investigator: Malcolm L. Snead, D.D.S., Ph.D.
. Agency: National Institute of Dental and Craniofacial Rsearch"
. Type: R01 (DE11834, Years, 1-4) August 1, 1997 to May 31, 2001
. The major goal of this project is to investigate the function of Von Ebner Gland's products in taste transduction.
"Cell and Genetic Approaches to Enamel Biomimetics"
. Principal Investigator: Malcolm L. Snead, D.D.S., Ph.D.
. Agency: National Institute of Dental and Ccraniofacial Research
. Type: R01 (DE 13045, Years, 1-5) August 1, 1998 to June 30, 2003
. The major goal of this project is to determine the effects of selected tooth specific proteins on mineral deposition and composition in vitro; using transgenic animals as part of a gain function test, determine the effects of excessive amounts of tuftelin and ameloblastin proteins on tooth biomineralization in vivo.
"Training in Cellular and Molecular Biology"
. Principal Investigator: Malcolm L. Snead, D.D.S., Ph.D.
. Type: T32 (DE07211, Years 1-10) September 30, 1990 to June 30, 2000
. The major goal of this project is to support dentist seeking advanced training in biomedical research appropriate to the mission of the NIDCR.
10 Selected Publications:
Click here to view all the publications for this faculty
Snead ML,Slavkin HC - Science is the fuel for the engine of technology and clinical practice. - J Am Dent Assoc [2009] Sep;140 Suppl 1():17S-24S PubMed
Buchko GW,Tarasevich BJ,Bekhazi J,Snead ML,Shaw WJ - A solution NMR investigation into the early events of amelogenin nanosphere self-assembly initiated with sodium chloride or calcium chloride. - Biochemistry [2008] Dec 16;47(50):13215-22 PubMed
Buchko GW,Bekhazi J,Cort JR,Valentine NB,Snead ML,Shaw WJ - H, C, and N resonance assignments of murine amelogenin, an enamel biomineralization protein. - Biomol NMR Assign [2008] Jun;2(1):89-91 PubMed
Buchko GW,Tarasevich BJ,Bekhazi J,Snead ML,Shaw WJ - A Solution NMR Investigation into the Early Events of Amelogenin Nanosphere Self-Assembly Initiated with Sodium Chloride or Calcium Chloride. - Biochemistry [2008] Nov 14;(): PubMed
Zhou Y,Snead ML - Derivation of cranial neural crest-like cells from human embryonic stem cells. - Biochem Biophys Res Commun [2008] Nov 21;376(3):542-7 PubMed
Wen X,Zou Y,Luo W,Goldberg M,Moats R,Conti PS,Snead ML,Paine ML - Biglycan overexpression on tooth enamel formation in transgenic mice. - Anat Rec (Hoboken) [2008] Oct;291(10):1246-53 PubMed
Snead ML - Whole-tooth regeneration: it takes a village of scientists, clinicians, and patients. - J Dent Educ [2008] Aug;72(8):903-11 PubMed
Huang Z,Sargeant TD,Hulvat JF,Mata A,Bringas P Jr,Koh CY,Stupp SI,Snead ML - Bioactive nanofibers instruct cells to proliferate and differentiate during enamel regeneration. - J Bone Miner Res [2008] Dec;23(12):1995-2006 PubMed
Paine ML,Snead ML,Wang HJ,Abuladze N,Pushkin A,Liu W,Kao LY,Wall SM,Kim YH,Kurtz I - Role of NBCe1 and AE2 in secretory ameloblasts. - J Dent Res [2008] Apr;87(4):391-5 PubMed
Warotayanont R,Zhu D,Snead ML,Zhou Y - Leucine-rich amelogenin peptide induces osteogenesis in mouse embryonic stem cells. - Biochem Biophys Res Commun [2008] Feb 29;367(1):1-6 PubMed
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