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Education:
BA 1981 Chemistry - Oberlin College, Oberlin, Ohio
PhD 1988 Biology - California Institute of Technology, Pasadena, California
Postdoctoral Research Fellowship:
1989 - 1994 The Salk Institute, San Diego, California
Started at USC: 1995 Research Topics: Developmental Biology, Stem Cell Biology, Cell Cycle, Growth & Proliferation, Signal Transduction, Cardiovascular & Skeletal Muscle Diseases
Research Description
Research in my lab is primarily oriented to understanding the cellular and molecular basis of cardiovascular development. Congenital cardiovascular defects are the most common class of birth defects; understanding basic CV developmental mechanisms provides insight into the etiology of these defects during development, and is also relevant to therapies that restore function in the context of adult heart disease.
My lab in particular investigates two major aspects of cardiovascular development (with several subprojects within each): ventricular chamber morphogenesis and outflow tract morphogenesis. We explore signaling and molecular regulatory processes that result in cardiomyocyte proliferation, in the assembly and organization of cardiomyocytes into the compact chamber wall, in secondary heart field formation and differentiation, in the formation of coronary vasculature, and in vascular smooth muscle differentiation. Molecular components of particular current interest include retinoic acid and retinoic acid receptors, and TGFb family members and their receptors, although we explore a number of additional signaling molecules and pathways and downstream components as well. For our studies, we primarily use genetically modified mouse lines bearing conventional or conditional (tissue-specific) gene mutations, but also employ tissue culture assays, biochemical approaches, and other model organisms as needed. We also explore other aspects of development using the tools of cell lineage analysis and conditional gene mutation that are at our disposal.
Current funding:
NIH R01 HL078891: TGFb and Cardiac Neural Crest Cell Fate and Function
NIH R01 HL070123: Cardiomyocyte Proliferation and Ventricular Morphogenesis
Honors and Awards: Dr. Sucov has been recognized several times by the American Heart Association for his work in cardiovascular development. He has served on many grant review panels and committees, and is currently a member of the NIH Cardiovascular Development and Differentiation (CDD) study section. In 2007, he was a Visiting Scholar of the Japanese Society for the Promotion of Science
10 Selected Publications:
Click here to view all the publications for this faculty
Nolting J,Daniel C,Reuter S,Stuelten C,Li P,Sucov H,Kim BG,Letterio JJ,Kretschmer K,Kim HJ,von Boehmer H - Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. - J Exp Med [2009] Sep 28;206(10):2131-9 PubMed
Sucov HM,Gu Y,Thomas S,Li P,Pashmforoush M - Epicardial Control of Myocardial Proliferation and Morphogenesis. - Pediatr Cardiol [2009] Mar 10;(): PubMed
Choudhary B,Zhou J,Li P,Thomas S,Kaartinen V,Sucov HM - Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. - Genesis [2009] Feb;47(2):115-21 PubMed
Asahina K,Tsai SY,Li P,Ishii M,Maxson RE Jr,Sucov HM,Tsukamoto H - Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. - Hepatology [2009] Mar;49(3):998-1011 PubMed
Chen YH,Ishii M,Sucov HM,Maxson RE Jr - Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. - BMC Dev Biol [2008] Jul 30;8():75 PubMed
Makita T,Sucov HM,Gariepy CE,Yanagisawa M,Ginty DD - Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. - Nature [2008] Apr 10;452(7188):759-63 PubMed
Kang J,Gu Y,Li P,Johnson BL,Sucov HM,Thomas PS - PDGF-A as an epicardial mitogen during heart development. - Dev Dyn [2008] Mar;237(3):692-701 PubMed
Chen YH,Ishii M,Sun J,Sucov HM,Maxson RE Jr - Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. - Dev Biol [2007] Aug 15;308(2):421-37 PubMed
Kameda Y,Nishimaki T,Chisaka O,Iseki S,Sucov HM - Expression of the epithelial marker E-cadherin by thyroid C cells and their precursors during murine development. - J Histochem Cytochem [2007] Oct;55(10):1075-88 PubMed
Wang J,Nagy A,Larsson J,Dudas M,Sucov HM,Kaartinen V - Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. - BMC Dev Biol [2006] Nov 1;6():51 PubMed
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