Timothy J. Triche Professor Pathology, Cancer Biology, Pediatrics The Saban Research Institute Childrens Hospital Los Angeles

Education:
AB 1966 Physics & Biology - Cornell University, Ithaca, NY
MD 1971 Medicine - Tulane University Medical Center, New Orleans, LA
PhD 1971 Cell Biology - Tulane University, New Orleans, LA

Postdoctoral Research Fellowship:
1974 - 1975 National Cancer Institute, Bethesda, Maryland

Started at USC: 1988

Research Topics: Cancer Cell Biology, Cancer Genetics, Cell Cycle, Growth & Proliferation, Vision Research

Research Description

My research focuses on genetic aspects of cancer biology and their biologic consequences. Current research emphasizes whole genome approaches to gene expression profiling and genomic polymorphisms using DNA microarrays and software developed by our group to analyze this data. Laboratory studies typically utilize tumor cell lines expressing transfected genes, or with silenced genes. Gene targets and biologically active small molecules are often analyzed in biologic context by these same methods. Clinical correlative studies utilize tumor tissue with linked clinical data. Recently, these methods have been applied to studies of age related macular degeneration, as part of the Beckman Macular Research Center at the Doheny Eye Institute, Keck School of Medicine.

LEGEND FOR SLIDE 1: (see below)

This diagram illustrates the power of mapping gene expression data to known or suspected signal transduction pathways. Here, a combination of MAPK, PI3-AKT, and NFkB pathways are mapped downstream of HER2/neu, with endpoints of proliferation (Ki-67) and apoptosis (BCL, caspase, etc.). Note that gene expression values are highly co-ordinated within datasets, and often show reciprocal changes. In each graph, two conditions (androgen exposed or not) and three treatments (neg HER2 control, low HER2, and high HER2) are illustrated. All data are in duplicate or more, and were normalized as a single dataset within our software, Genetrix.